RESUMO
BACKGROUND: Lung adenocarcinoma (LUAD) is the most common dangerous malignant tumor and the leading cause of global cancer incidence and mortality. The Solute Carrier 1A (SLC1A) family play a significant part in cellular biological process, inflammation, and immunity. Specific functions of the SLC1A family in lung cancer are still not systematically described. OBJECTIVE: This study aimed to explore the best biological understanding of SLC1A family in lung cancer. METHODS: To study the expression and role of the SLC1A family in lung cancer, researchers used a variety of bioinformatics databases and tools. RESULTS: Aberrant expression of SLC1A family genes were demonstrated and analyzed the association with gender, tumor grade, cancer stages, and nodal metastasis status. The ectopic expression of SLC1A family genes has prognostic value for LUAD patients. Immune infiltration revealed a significant correlation between SLC1A family genes expression in LUAD. SLC1A family genes were involved in manifold biological processes and have different levels of DNA methylation and genetic alteration. CONCLUSIONS: These findings suggested that members of the SLC1A family could be a potential target for the development of LUAD therapeutics as well as a reliable indicator of LUAD prognostic value.
RESUMO
The differential evolution algorithm (DEA)-based iterative sliding mode control (ISMC) method was proposed for the path tracking problem of three-degree-of-freedom (3-DoF) underactuated ships under external interference, with the nonlinear separate model proposed by mathematical model group (MMG). To improve control quality and enhance robustness of the control system, a swarm intelligence optimization algorithm is used to design a controller parameter optimization system. The DEA was adopted in the system to solve the minimum system evaluation index function, and the optimal controller parameters are acquired. Considering the impact of chattering on the actual project, a chattering measurement function is defined in the controller design and used as an input of the controller parameter optimization system. Finally, the 5446TEU container ship is carried out for simulation. It is verified that the designed controller with strong robustness can effectively deal with the disturbances; meanwhile, the chattering of the output is significantly reduced, and the control rudder angle signal conforms to the actual operation requirements of the ship and is more in line with the engineering reality.
