Comparing the photodegradation of typical antibiotics in ice and in water: Degradation kinetics, mechanisms, and effects of dissolved substances.

New antibiotic contaminants have been detected in both surface waters and natural ice across cold regions. However, few studies have revealed distinctions between their ice and aqueous photochemistry. In this study, the photodegradation and effects of the main dissolved substances on the photolytic kinetics were investigated for sulfonamides (SAs) and fluoroquinolones (FQs) in ice/water under simulated sunlight. The results showed that the photolysis of sulfamethizole (SMT), sulfachloropyridazine (SCP), enrofloxacin (ENR) and difloxacin (DIF) in ice/water followed the pseudo-first-order kinetics with their quantum yields ranging from 4.93 × 10-3 to 11.15 × 10-2. The individual antibiotics experienced disparate photodegradation rates in ice and in water. This divergence was attributed to the concentration-enhancing effect and the solvent cage effect that occurred in the freezing process. Moreover, the main constituents (Cl-, HASS, NO3- and Fe(III)) exhibited varying degrees of promotion or inhibition on the photodegradation of SAs and FQs in the two phases (p < 0.05), and these effects were dependent on the individual antibiotics and the matrix. Extrapolation of the laboratory data to the field conditions provided a reasonable estimate of environmental photolytic half-lives (t1/2,E) during midsummer and midwinter in cold regions. The estimated t1/2,E values ranged from 0.02 h for ENR to 14 h for SCP, which depended on the reaction phases, latitudes and seasons. These results revealed the similarities and differences between the ice and aqueous photochemistry of antibiotics, which is important for the accurate assessment of the fate and risk of these new pollutants in cold environments.

Cuproptosis-related gene SLC31A1: prognosis values and potential biological functions in cancer.

Cuproptosis is a unique type of cell death that may influence tumour formation by targeting lipoylated tricarboxylic acid cycle proteins. Solute carrier family 31 member 1 (SLC31A1), an important copper transporter, influences dietary copper absorption in the cell membrane. However, various SLC31A1 properties in pan-cancer profiles remain unknown. This study investigated the role of SLC31A1 in human malignancies and analysed its prognostic value. Raw data were obtained from The Cancer Genome Atlas database and processed using numerous internet databases, including UALCAN, GEPIA, cBioPortal, TIMER2.0, and Human Protein Atlas. SLC31A1 expression was found to be elevated in cervical, endometrial, and breast cancers compared to that in normal tissues, but reduced in clear cell renal cell carcinoma, liver hepatocellular carcinoma, and lung adenocarcinoma. Furthermore, SLC31A1 expression was strongly associated with overall survival and disease-free survival in several cancers. SLC31A1 gene mutations and methylations were identified in 33 cancers. SLC31A1 expression was positively correlated with immune cells in immune infiltration data. Single-cell sequencing revealed that SLC31A1 may play key roles in DNA repair, DNA damage, and proliferation. These findings may lead to better understanding of SLC31A1 in pan-cancer profiles and suggest that SLC31A1 could be a viable predictive biomarker, particularly in gynaecological cancers.

Insight into typical photo-assisted AOPs for the degradation of antibiotic micropollutants: Mechanisms and research gaps.

Due to the incomplete elimination by traditional wastewater treatment, antibiotics are becoming emerging contaminants, which are proved to be ubiquitous and promote bacterial resistance in the aquatic systems. Antibiotic pollution has raised particular concerns, calling for improved methods to clean wastewater and water. Photo-assisted advanced oxidation processes (AOPs) have attracted increasing attention because of the fast reaction rate, high oxidation capacity and low selectivity to remove antibiotics from wastewater. On the basis of latest literature, we found some new breakthroughs in the degradation mechanisms of antibiotic micropollutants with respect to the AOPs. Therefore, this paper summarizes and highlights the degradation kinetics, pathways and mechanisms of antibiotics degraded by the photo-assisted AOPs, including the UV/O3 process, photo-Fenton technology, and photocatalysis. In the processes, functional groups are attacked by hydroxyl radicals, and major structures are destroyed subsequently, which depends on the classes of antibiotics. Meanwhile, their basic principles, current applications and influencing factors are briefly discussed. The main challenges, prospects, and recommendations for the improvement of photo-assisted AOPs are proposed to better remove antibiotics from wastewater.

Peutz-Jeghers syndrome with gastric-type mucinous endocervical adenocarcinoma and sex-cord tumor with annular tubules: A case report.

Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant genetic disorder characterized by mucocutaneous pigmentation and multiple hamartomatous polyps in the gastrointestinal tracts. About 11% of female PJS patients are diagnosed with Gastric-type endocervical adenocarcinoma (G-EAC) and about one third have a sex-cord tumor with annular tubules (SCTATs). Gastric-type endocervical adenocarcinoma is a special subtype of cervical adenocarcinoma which accounts for only 1-3%. Here we report a rare case of a 31-year-old woman affected with G-EAC and SCTAT accompanied by PJS. After surgery, we followed up for 5 years without recurrence.

N-[1-(1H-Pyrrol-2-yl)ethyl-idene]aniline.

There are two independent mol-ecules in the asymmetric unit of the title compound, C(12)H(12)N(2), in which the pyrrole and benzene rings form dihedral angles of 72.37 (7) and 82.34 (8)°. The imino N-C bond lengths in the two mol-ecules are equal [1.286 (2) Å] and indicate C=N character. In the crystal, each mol-ecule forms a dimer with an inversion-related mol-ecule through a pair of classical N-H⋯N hydrogen bonds.

2,4,6-Trimethyl-N-[1-(1H-pyrrol-2-yl)ethyl-idene]aniline.

There are two independent mol-ecules in the asymmetric unit of the title compound, C(15)H(18)N(2), each of which features a syn disposition of the N atoms. In each mol-ecule, the pyrrole and benzene rings are essentially perpendicular, with dihedral angles of 78.90 (9) and 79.96 (9)°. In the crystal, the independent mol-ecules are connected by a pair of pyrrole-imino N-H⋯N hydrogen bonds, forming a two-mol-ecule aggregate.