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OBJECTIVE:To observe clinical efficacy of Shenshao capsules in the treatment of unstable angina(UA)of coro-nary heart disease,and its effects on heart rate,blood pressure,myocardial consumption of oxygen (MCO),serum levels of hs-CRP and MMP-9. METHODS:77 UA patients with coronary heart disease selected from our hospital during May 2014-May 2016 were divided into observation group (39 cases) and control group (38 cases) according to random number tablet. Control group received rountine treatment. Observation group was additionally given Shenshao capsule 1.2 g,tid,on the basis of control group. Both groups were treated for 4 weeks. The heart rate,blood pressure,myocardial oxygen consumption,serum levels of hs-CRP and MMP-9 in 2 groups were observed before and after treatment;stopping and reduced rate of nitroglycerin,and therapeu-tic efficacy of ECG ST segment were compared between 2 groups. RESULTS:There was no statistical significance in heart rate, blood pressure,myocardial oxygen consumption,serum levels of hs-CRP and MMP-9 between 2 groups before treatment (P>0.05). After treatment,above indexes of 2 groups were decreased significantly,and the observation group was significantly lower than the control group,with statistical significance (P<0.05). The stopping and reduced rate of nitroglycerin,total response rate of ECG ST segment were 82.1%,87.2%in observation group,which were better than 63.2%,78.9%in control group,with statis-tical significance(P<0.05). CONCLUSIONS:Shenshao capsules is effective for coronary heart disease UA,and can effectively re-duce heart rate,blood pressure,myocardial oxygen consumption,serum levels of hs-CRP and MMP-9.
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OBJECTIVE:To provide reference for the rational use of TCM injections. METHODS:487 medical records using TCM injection in our hospital from Jul. to Dec. 2014 were selected as control group,another 500 from Jan. to Jun. 2015 were inter-vention group. Utilization,rationality and adverse reactions of TCM injection between 2 groups were compared. RESULTS:Accord-ing to the intervention by clinical pharmacists,the sales amount and utilization rate of top 10 TCM injection in our hospital were lower significantly. The irrational utilization rate of 5 types (totally 26 varieties) in intervention group decreased (21.60% vs. 43.33%),incidences of adverse reactions reduced(3.00% vs. 7.39%),compared with control group,the differences were statisti-cally significant (P<0.05). Treatment cost per capita [(217.17 ± 22.64) yuan vs. (480.77 ± 21.35) yuan] and hospitalization time [(6.50 ± 1.99)d vs. (10.02 ± 3.25)d] in intervention group were significantly lower or shorter than control group,the differences were statistically significant (P<0.05). CONCLUSIONS:Implementing pharmaceutical interventions can strengthen the sense of clinicians’rational use of TCM injection,raise the level of rational use of drugs and reduce adverse reactions and medical errors.
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OBJECTIVE:To observe the clinical efficacy of Chinese medicine inunction wet dressing therapy and helium neon laser in the treatment of rheumatoid arthritis.METHODS:Both groups received Methotrexate tablets,Salazosulfapyridine tablets,Loxoprofen tablets.Observation group were additionally treated with Chinese medicine inunction wet dressing therapy and helium neon laser with a treatment course of 30 days.RESULTS:The effective rate was 70.00% for control group and 93.55% for observation group,there was significant difference between two groups(P
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OBJECTIVE: To provide reference the utilization of pharmacy resources on Internet.METHODS: The experience and practice of clinical pharmacy in our hospital were summarized.Domestic and foreign websites which were used by clinical pharmacists were collected and introduced.RESULT & CONCLUSION: There are plenty of pharmacy resources on Internet that can contribute to the development of clinical pharmacy.
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OBJECTIVE:To introduce a self-cure method for the cough caused by cold.METHODS:By placing control group and trial group,30 cases(control group)were assigned to receive Dextromethorphan Hydrobromide oral liquid and 32 cases(trial group)to employ self-cure method for cough caused by cold.And a self-cure method for the cough caused by cold was induced.RESULTS & CONCLUSION:The practice of self-cure method can speed up the self-cure of cough caused by cold and this method deserves to be popularized.
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OBJECTIVE:To observe the clinical effect of Shenmai injection for primary sjogren syndrome.METHODS:61 patients were randomized to receive anethole trithione (control group,n=29) or anethole trithione and Shenmai injection (treatment group,n=32) respectively with 15 days as a course of treatment.RESULTS:The total effective rate was 68.96% for control group and 90.63% for treatment group.There were 3 cases of abdominal discomfort ordiarrhea in control group,and no serious ADR was detected in treatment group.Significant difference was noted between two groups (P
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OBJECTIVE: To observe the clinical character of antibiotic associated diarrhea(AAD)in order to provide reference for prevention measures. METHODS: Retrospective analysis was applied to analyze 488 inpatients treated with antibiotics in our hospital from 2006 to 2008,of which 42 AAD cases were analyzed in terms of clinical manifestation,utilization of antibiotics, therapy and prognosis, etc. RESULTS: The incidence of AAD arrived at 8.6%. The reason that incidence of AAD was higher than that of control group was above 7 days of antibiotics treatment, broad-spectrum antibiotic, more than two kinds of antibiotics and over 70 years old. CONCLUSION: The key point of preventing AAD is rational use of antibiotics.
