RESUMO
OBJECTIVE: Many studies have emphasized the possible role of probiotics in psoriasis, probiotic supplementation might be helpful to treat psoriasis. This study systematically evaluated the efficacy of probiotic supplementation for the treatment of psoriasis. METHODS: We searched some databases with keywords until November 10, 2023, including PubMed, Cochrane Library, Embase, and Web of Science. These keywords included probiotics, psoriasis RCT, and so on. After rigorous literature screening by two authors, five studies were identified. Eventually, the required data were independently extracted by another author. RESULTS: A total of five studies with 286 patients were included. The pooled results showed that the efficacy of probiotic supplementation was superior to placebo in the treatment of psoriasis. The Psoriasis Area and Severity Index (SMD = -1.40, 95% Cl = -2.63 to -0.17, p < 0.00001) and Dermatology Life Quality Index (SMD = -0.92, 95% Cl = -1.86 to 0.01, p < 0.00001). Score decreased after probiotic supplementation. CONCLUSIONS: The meta-analysis showed that probiotic supplementation could be a new treatment option for psoriasis.
RESUMO
To enhance the hexavalent chromium (Cr(VI)) removal performance of simulated constructed rapid infiltration systems (CRIS) with quartz sand (QS) substrate, QS coated with Al-layered double hydroxides (Al-LDHs@QS) was prepared by the co-precipitation method under alkaline conditions. A scanning electron microscope (SEM), energy dispersive spectrometer (EDS) and X-ray diffractometer (XRD) were used to characterize QS before and after modification. The result showed that the Al-LDHs were successfully coated on the surface of the QS. The isotherm adsorption experiment indicated that compared with the original QS, the adsorption property of the modified QS changed from monolayered chemical adsorption to multilayered physical adsorption, perhaps because of different types of adsorption forces. Moreover, the adsorption capacity of modified QS was significantly enhanced and ZnAl-LDHs@QS had a maximum adsorption capacity (1428.57 mg·kg-1) nearly 6 times greater than that of the original QS (232.56 mg·kg-1). Adsorption experiments at different pH showed that the adsorption capacity of ZnAl-LDHs@QS gradually increased as acidity decreased. High-throughput sequencing revealed that the relative abundance of chrome-tolerant microorganisms at the phylum and family levels were increased in modified QS compared with original QS. Hemocytometer counting revealed enhanced microbial quantity on the surface of QS after modification. The content of extracellular polymeric substances (EPS) and the enzymatic activity of the microorganisms adhered to the surface of modified and original QS were detected, results showed that Al-LDHs had an obvious influence on the promotion of EPS secretion and enhanced the enzymatic activity of microorganisms. These changes indicated that the modified QS created better conditions for microorganism growth, and the improved microbial effect caused strong biosorption, resulting in greatly enhanced Cr(VI) removal. Thus, ZnAl-LDHs@QS is a better choice for CRIS to remove Cr(VI).
