Effective health management strategies for patients undergoing valve replacement: a bibliometric analysis of the current research status and future directions.

Background: Valvular heart disease is a major health concern worldwide. The effective management of patients undergoing valve replacement determines their prognosis. Bibliometric analysis of studies on managing patients with artificial heart valves has not been previously performed. Methods: This study analyzed 2,771 publications related to patient management after valve replacement published in the Web of Science Core Collection database between January 1, 2013, and December 31, 2022. Bibliometric analysis was performed using CiteSpace and VOSviewer considering countries, institutions, authors, journals, references, and keywords. Results: The countries with the most significant contributions in this field were the United States of America (USA), Germany, and Italy. Leon MB from Columbia University, USA was the most influential author. Transcatheter aortic valve replacement was a current research hotspot, while anticoagulation management was a key area of interest. Combining anticoagulation therapy with internet-linked tools and portable health devices may offer new research avenues. Frailty assessment and intervention were potential future research areas. Conclusions: This bibliometric analysis provides clinicians and researchers with useful insights for developing novel ideas and directions to manage the health of patients undergoing valve replacement.

Classification of GINS family members based on their expression levels in glioma tissues and its clinical significance / 中国肿瘤生物治疗杂志

@#[摘 要] 目的：基于GINS家族成员在胶质瘤组织中表达水平对其分型，探究此分型预测胶质瘤患者的预后、免疫治疗疗效的有效性，采用TCMOI数据库虚拟筛选可靶向GINS的中药小分子。方法：数据库分析GINS基因组学、胶质瘤组织中差异表达基因与患者预后的关系，基于GINS家族成员基因表达对胶质瘤进行分型并分析各亚型的预后情况，数据库数据分析各亚型中的基因突变、基因富集、肿瘤纯度和免疫细胞浸润评分，以及与GINS2可能相互作用的中药小分子，最后用qPCR法检测中国人胶质瘤组织中GINS1~4 mRNA的表达水平以验证其与数据库数据的一致性。结果：GINS家族各成员间的基因、蛋白结构和功能相似，胶质瘤组织中GINS家族成员呈高表达且与患者不良预后密切相关（P<0.05），基于GINS家族成员在胶质瘤组织中表达水平的S1、S2亚型分类能较好地预测胶质瘤患者的预后，S1亚型主要突变基因为CDKN2A/B、EGFR、PTEN而S2亚型的突变基因为IDH1、TP53和ATRX，GINS家族可能通过调控免疫微环境影响胶质瘤患者预后，CD276和CX3CL1可能是S1亚型胶质瘤患者实施免疫治疗的潜在靶点，CHEMBL66033、266935、293914、436859、1594881可能是潜在的靶向GINS2的中药小分子。结论：基于GINS家族构建的胶质瘤分子分型有助于识别更适合免疫治疗的高风险患者，筛选出的中药小分子可为胶质瘤患者分子靶向治疗和免疫治疗提供参考。

Relationship Between Family Caregiver Burden and Medication Adherence in Patients with Mechanical Valve Replacement: A Structural Equation Model.

Background: Oral anticoagulant is a necessary long-term treatment after mechanical valve replacement (MVR), and medication adherence has a great impact on patients with MVR. Although family caregiver burden is negatively correlated with medication adherence, little is known about the underlying mechanism. Purpose: To test whether family caregiver burden influences medication adherence through post-traumatic growth or medication literacy in patients with MVR. Patients and Methods: A total of 206 patients after MVR were included in this cross-sectional study from July 2021 to December 2021. Data regarding medication adherence, family caregiver burden, post-traumatic growth, and medication literacy were collected by questionnaires. Data were analyzed through SPSS, and pathway analysis was conducted by using AMOS, based on the bootstrapping method. Results: Post-traumatic growth was positively associated with medication adherence (r = 0.284, P < 0.05). Post-traumatic growth independently mediated the association of family caregiver burden on medication adherence [ß = 0.32, 95% confidence intervals: (-0.016, -0.008)]. The mediated effect value for post-traumatic growth was 0.07, accounting for 24.14% of the total effect. The model's fit indices were adequate. Conclusion: The mediating effect of post-traumatic growth between family caregiver burden and medication adherence existed in patients with MVR. Interventions considering post-traumatic growth may be useful to increase medication adherence and improve patient rehabilitation.

A cross-sectional descriptive study of pressure ulcer prevalence in a teaching hospital in China.

Surveying pressure ulcer (PU) prevalence is a common practice in some western countries and has served as a tool to improve prevention policies and procedures. Although attention on PU prevention has increased in China, no PU prevalence baseline information is available to help guide care. To obtain this baseline information, a cross-sectional descriptive study was conducted in a 3,000-bed teaching hospital in Wuhan. On the morning of the study, trained clinicians audited the total hospital patient population (61 nursing units, 2,913 inpatients) using the PU survey tool designed by National Database of Nursing Quality Indicators. The majority of the patients (1,648, 56.6) were male, average patient age was 43.91 (+/-21.20) years, range 1 to 94 years. The overall PU prevalence rate was 1.8% (52 patients/79 ulcers). The hospital-acquired prevalence rate was 1.54% (0.82% when Stage I ulcers were excluded). Prevalence rates were highest in the ICU (45.5%) and most ulcers (53.2%) were located in the sacral-coccyx area. The results of this study suggest that overall PU prevalence rates are low compared to data from other countries. Differences in patient acuity, average patient length-of-stay, and prevention practices may explain these observations. The results of this study can guide hospital prevention efforts and serve as a benchmark for PU prevalence studies in China.