[Proteolytic processes in lung tissue of rat posterity after whole-body chronic irradiation with low doses].

Intensification of proteolytic processes accompanied by inhibited antiprotease activity in lung tissue of first generation posterity of rats irradiated with a total dose of 0.25 Gy (0.01 Gy per day) before gestation was shown. The obtained data satisfied to imbalance in functioning of regulation systems, tension of adaptation mechanisms with possible rapider reduction of adaptation resistance of broncho-lung system of irradiated parents' posterity. Vector changes in correlation of indexes in the proteinase-antiproteinase system were analogous in all experimental series (irradiated male x irradiated female, irradiated male x intact female, intact male x irradiated female) with maximal expression in the group obtained from parents both irradiated before gestation. It could be possible to propose a presence of non-stable genome in posterity of irradiated parents, that satisfied to role of genetic aspects in development of the late functional disorders.

[Lipid metabolism characteristics in disabled persons as a consequence of cerebrovascular diseases]. / Osobennosti lipidnogo obmena u invalidov vsledstvie tserebrovaskuliarnykh zabolevanii.

Lipid metabolism condition in young, mature (till 35 y.o) and elderly disabled persons as a consequence of cerebral diseases has been investigated. It was established that all three groups differ in clinical presentation and various kinds of lipid metabolism abnormalities. It is of great importance as to more thoroughly understand the development of cerebrovascular diseases and plan an individual program of treatment.

[The biological effects of combined exposure to low-dose irradiation and heavy metal ions]. / Biologicheskie éffekty kombinirovannogo vozdeistviia nizkodozovogo oblucheniia i ionov tiazhelykh metallov.

It was shown that chronic 0.25 Gy irradiation of rats (0.01 Gy/day) at background of heavy metal penetration (Cu2+, 20 mg/l or Co2+, 5 mg/l) with drinking water had caused significant accumulation of the free-radical products proportional to exhausting antioxidant and oxidizing-reduction potential in various organs and tissues. Radiation was shown to be primary harmful factor for the brain, spleen, lungs, and blood plasma, whereas the liver and heart muscle were affected with chemicals at first. Under prolonged unfavourable influence the biochemical changes observed were sustainable and progressing that satisfied to transformation of protective-adaptive reactions into prepathology stage.

[Lipid peroxidation in the lungs upon inhalation exposure to low concentrations of lead salts]. / Peroksidnoe okislenie lipidov v legkikh pri ingalatsionnom vozdeistvii soli svintsa v nizkikh kontsentratiiakh.

Effects of inhalation with low concentration lead salts on lipid peroxidation intensity and antioxidative system state were investigated in respiratory pulmonary branch in rats after both short-term and chronic exposures to 0.01% Pb(CH3COO)2. It was shown that the short-term toxic action had considerably affected on the antioxidant system state in lungs as a result of tissue antioxidative activity exhausting. Under the chronic lead inhalation penetrating disorders in adaptive mechanisms were found. It was reflected in lipid peroxidation product accumulation and decreased parameters of antioxidant defense, and development of energy deficiency.

[Proteolytic system in lungs upon inhalation exposure to low doses of lead salts]. / Sistema proteoliza v legkikh pri ingaliatsionnom vozdeistvii soli svintsa v nizkikh kontsentratsiiakh.

Changes in proteinase--antiproteinase activities in lungs as a result of short-term (for 1 week) inhalation of rats with 0.01% (CH3COO)2 Pb have wholly compensative patterns, but it have been found increased cathepsine B activity as a negative prognostic factor. Chronic (for 2 month) toxicant inhalation caused considerable activation of both trypsine and cathepsine B under decreasing alpha 1-antitrypsine and alpha 2-macroglobuline activities. Cathepsine L activity was not affected. Disorders in the proteolysis system were evaluated as desadaptation situation in lung tissue under chronic toxic influence.

[The effect of x-ray radiation and hypoxia on the proteolytic activity of the normal rat spleen and during tumor growth]. / Vliianie rentgenovskogo izlucheniia i gipoksii na proteoliticheskuiu aktivnost' selezenki krys v norme i pri opukholevom roste.

The influence of X-radiation on activity of lysosomal enzymes (D, L, H cathepsins) in rat spleen tissue and in inoculated rat sarcoma 45 has been investigated. Intact rats and rats with tumors were subjected to whole-body and sarcoma 45 to local irradiation with doses of 0.155 C/kg and 0.31 C/kg in conditions of breathing gas hypoxic mixture containing 90% of nitrogen and 10% of oxygen (GHM-10). The combined exposure to radiation and GHM-10 was shown to produce a certain protective action (e.g. normalized cathepsin activity) in the spleen. In the tumor tissue the protective effect of GHM-10 was absent.