1.
J Nanosci Nanotechnol
; 6(9-10): 3210-4, 2006.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17048538
RESUMO
A novel controlled drug delivery system was fabricated by coating chitosan/PAA multilayer onto magnetic hollow spheres via a "Layer-by-Layer" (LBL) assembly approach. Cefradine was used as a model drug to evaluate the drug release characteristics of this core-shell hollow structure and the results show that it exhibits a sustained release of the drug and the release rate can be regulated by the pH environment of release medium. It is believed that this core-shell hollow structure, which combines the advantage of controlled delivery as well as magnetic targeting, has commendable potential in drug delivery therapeutics.