1.
Bioorg Med Chem Lett
; 18(14): 4006-10, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18571921
RESUMO
A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH(2)-substituted benzyl moiety have been synthesized and evaluated for p38alpha MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38alpha MAP kinase with IC(50) values 27.6, 28, and 31 nM, respectively.