Fluoroscopic sniff test as a diagnostic tool for phrenic nerve injury in patients with traumatic brachial plexus injury.

OBJECTIVE: Traumatic brachial plexus injury (BPI) is a high-morbidity condition with an escalating incidence. One of the treatment options is neurotization using the ipsilateral phrenic nerve. Therefore, diagnosis of nerve dysfunction is a crucial step in preoperative planning. This study aimed to assess the accuracy and reliability of the fluoroscopic sniff test for preoperative diagnosis of phrenic nerve injury in patients with traumatic BPI. METHODS: The study was conducted from June 2019 to August 2023 at a tertiary care hospital. A preoperative fluoroscopic sniff test was performed. During brachial plexus surgery, direct phrenic nerve stimulation was conducted as a gold standard of phrenic nerve function. Two nonoperating orthopedic surgeons interpreted the accuracy and reliability of the test. RESULTS: Seventy-four patients with traumatic BPI (66 males and 8 females) with a median age of 26 years were enrolled. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the fluoroscopic sniff test were 90.9% (95% CI 75.7%-98.1%), 100% (95% CI 91.4%-100%), 100% (95% CI 88.4%-100%), 93.2% (95% CI 82.3%-97.6%), and 95.9% (95% CI 88.6%-99.2%), respectively. Interobserver reliability showed excellent agreement (κ = 1, p < 0.001). CONCLUSIONS: The fluoroscopic sniff test was proven to be an accurate, reliable, and simple tool to evaluate phrenic nerve function in patients with traumatic BPI. Preoperative testing should be performed to reduce operative time to identify the phrenic nerve as a donor for nerve transfer surgery in cases in which no function is detected from the fluoroscopic sniff test.

Effect of shorter nerve graft and selective motor branch of recipient nerve on nerve transfer surgery for elbow flexion in patients with brachial plexus injury.

OBJECTIVE: The spinal accessory nerve (SAN) is commonly used as a donor nerve for reinnervation of elbow flexors in brachial plexus injury (BPI) reconstruction. However, no study has compared the postoperative outcomes between SAN-to-musculocutaneous nerve (MCN) transfer and SAN-to-nerve to biceps (NTB) transfer. Thus, this study aimed to compare the postoperative time to recovery of elbow flexors between the two groups. METHODS: A total of 748 patients who underwent surgical treatment for BPI between 1999 and 2017 were retrospectively reviewed. Among them, 233 patients were treated with nerve transfer for elbow flexion. Two techniques were used to harvest the recipient nerve: the standard dissection technique and the proximal dissection technique. The postoperative motor power of elbow flexion was assessed every month for 24 months using the Medical Research Council (MRC) grading system. Survival and Cox regression analyses were used to compare the time to recovery (MRC grade ≥ 3) between the two groups. RESULTS: Of the 233 patients who underwent nerve transfer surgery, there were 162 patients in the MCN group and 71 patients in the NTB group. At 24 months after surgery, the MCN group had a success rate of 74.1%, and the NTB group had a success rate of 81.7% (p = 0.208). When compared with the MCN group, the NTB group had a significantly shorter median time to recovery (19 months vs 21 months, p = 0.013). Only 11.1% of patients in the MCN group regained MRC grade 4 or 5 motor power 24 months after nerve transfer surgery compared with 39.4% patients in the NTB group (p < 0.001). Cox regression analysis showed that the SAN-to-NTB transfer in combination with the proximal dissection technique was the only significant factor affecting time to recovery (HR 2.33, 95% CI 1.46-3.72; p < 0.001). CONCLUSIONS: SAN-to-NTB transfer in combination with the proximal dissection technique is the preferred nerve transfer option for restoration of elbow flexion in traumatic pan-plexus palsy.

Risk prediction model for unsuccessful elbow flexion recovery after nerve transfer surgery in patients with brachial plexus injury.

OBJECTIVE: Nerve transfer surgery has been a mainstay treatment of brachial plexus injury, with varying success rates. Patients undergoing unsuccessful surgery are left with a useless limb for at least 2 years. Preoperative prediction has become a topic of interest to avoid an unsuccessful nerve transfer surgery. This study aimed to find strong predictive factors and develop a prediction model for unsuccessful functional elbow flexion recovery 2 years after a nerve transfer surgery in patients with brachial plexus injury. METHODS: This retrospective study reviewed the medical records of 987 patients with traumatic brachial plexus injury who underwent brachial plexus surgery by five hand and microsurgery surgeons at a single tertiary care referral center from December 2001 to July 2018. Four hundred thirty-three patients were eligible for analysis. Patient demographic data, injury factors, surgical details, and postoperative factors were collected. Multivariable logistic regression was used to identify strong prognostic factors for unsuccessful nerve transfer surgery for elbow flexion. A simplified model was developed by rounding the coefficient to the nearest 0.5 score or an integer. Both original and simplified models were validated using the Hosmer-Lemeshow goodness-of-fit test and bootstrapping. RESULTS: A full, original prognostic model from a stepwise backward logistic regression consisted of a BMI ≥ 23 kg/m2 (p = 0.015), smoking (p = 0.046), total arm-type injury (p = 0.033), donor nerve (p < 0.001), associated upper-extremity fracture (p = 0.013), and associated ipsilateral vascular injury (p = 0.095). The areas under the receiver operating characteristic curve of the original and simplified models were 0.765 and 0.766, respectively. The Hosmer-Lemeshow test showed good agreement of predicted and observed probability of the original (p = 0.49) and simplified (p = 0.19) models. Bootstrapping estimated an average optimism (1.9%) in the original model and minimal optimism (0.1%) in the simplified model. CONCLUSIONS: The prediction model for failed elbow flexion recovery after nerve transfer surgery in traumatic brachial plexus injury was developed with good predictive value and internal validity. An alternative treatment, i.e., primary free functioning muscle transfer, should be offered in preoperative counseling in cases of a very high risk of failure.

Comparative clinical and radiographic outcomes between early and delayed wrist mobilization after volar fixed-angle plate fixation of distal radius fracture.

Postoperative immobilization protocols after volar fixed-angle plate fixation of distal radius fractures (DRF) vary among surgeons. This study aimed to compare functional outcomes, radiographic parameters, and complications between early and delayed mobilization after volar fixed-angle plate fixation of DRF. This study is a randomized controlled trial. The early group was allowed to perform wrist motion exercise immediately after surgery and the delayed group was allowed to perform it after 2 weeks of external immobilization. Postoperative patient-rated wrist evaluation (PRWE), disabilities of arm, shoulder, and hand (DASH), wrist range of motion, visual analog scale (VAS) pain score, and grip strength were evaluated. Forty-eight patients with DRF were enrolled and randomly allocated to the early or delayed mobilization groups. The PRWE, DASH, VAS pain score, grip strength, and wrist motion of both groups significantly improved over time. However, there were no significant differences between groups at any timepoint. Radiographic parameters were not different between groups. There were no significant differences in functional outcomes, radiographic parameters, and complications between early and delayed mobilization after volar fixed-angle plate of DRF. Immediate postoperative wrist range-of-motion exercise can be safely initiated after volar fixed-angle plate fixation of DRF without external immobilization.Clinical trial registration: Thaiclinicaltrials.org identifier: TCTR20180927005. Registered 27/09/2018-retrospectively registered. https://www.thaiclinicaltrials.org/show/TCTR20180927005 .

Reliability of capillary refill time for evaluation of tissue perfusion in simulated vascular occluded limbs.

PURPOSE: No standardized execution or evidence demonstrates the area of the digit giving the most accurate capillary refill time (CRT). This study investigated the reliability and validity of CRT, and the relative merits of areas where the test could be performed. METHODS: In all, 127 healthy volunteers were assessed for normal CRT at the fingernail, lateral paronychia, and proximal and distal pulps of the index finger. The predictive validity of the CRT for the diagnosis of compromised vascular perfusion was also investigated on 24 subjects, using an inflated tourniquet. Three raters assessed interobserver reliability. RESULTS: The mean fingernail, lateral paronychia, proximal pulp, and distal pulp CRTs were 1.93, 1.78, 1.70, and 1.57 s, respectively. The tourniquet and non-tourniquet results demonstrated significant mean differences; however, the fingernail showed a subtle difference (1.22 s) compared with the proximal pulp (4.46 s). The CRT interobserver reliability was fair at the fingernail (intraclass correlation coefficient [ICC] = 0.51), but very poor in occluded limbs (ICC = 0.13). At the lateral paronychia and finger pulp, the interobserver reliability was reasonable (ICC = 0.75-0.81 [non-tourniquet] vs 0.62-0.68 [tourniquet]). In a receiver-operating characteristic curve analysis, the proximal pulp demonstrated better discrimination (area under the curve = 0.93, 95% CI 0.89-0.97, p < 0.0001); the best cutoff point was calculated to be 3 s at the proximal pulp. CONCLUSIONS: CRT use at appropriate areas is reliable. The most dependable site is the finger pulp, and the proposed cutoff is 3 s.

Topical anaesthesia as an adjuvant to local anaesthetic injection in open trigger digit release: a randomized controlled trial.

We conducted a randomized controlled trial to compare pain scores and patient satisfaction between topical anaesthetic cream (5% lidocaine-prilocaine cream) versus placebo cream, applied approximately 90 minutes before local anaesthetic injection for open trigger digit release. One hundred participants were enrolled and randomly allocated into the two groups between May 2019 and February 2020. The visual analogue pain scores and satisfaction scores were measured. Most participants were female with Quinnell Grade 2-3 trigger digits. The pain scores during needle injection, local anaesthetic infiltration, the overall pain and satisfaction scores had no statistically significant differences between groups. There was no correlation between duration of topical anaesthetic drug application and pain scores. Subgroup analysis did not show significant differences in pain scores between genders. No complications were found during the study period. The topical anaesthetic drug was ineffective to use on the palmar skin during open trigger digit release surgery.Level of evidence: II.

Cost-saving Minimal Incision Endoscopic-assisted Cubital Tunnel Release Using Simple Surgical Instruments: Case Series.

Cubital tunnel syndrome (CuTS) is a well-recognized compressive neuropathy worldwide. With technological advancement, endoscopy is introduced to facilitate the procedure. However, there are concerns about the excessive cost that comes with special instruments. This article aims to provide the results of the cost-saving endoscopic-assisted cubital tunnel release surgical technique that uses the normally available operating instruments. A retrospective review was performed of the nine patients that were diagnosed with CuTS and underwent minimal incision endoscopic-assisted cubital tunnel release in Police General Hospital. Patients were followed up to sixth month postoperation. The modified McGowan classification was used to determine the severity of symptoms. Surgical outcomes were evaluated by the modified Bishop classification, visual analog score (VAS), and patients' satisfaction. Other factors investigated were scar pain and peri-incisional numbness and hematomas. The incisions were measured as 7-9 mm. All patients reported having a pain score of 1 on the third day. Seven of nine patients were able to return to work one day after surgery. Modified Bishop score showed five excellence, three good, and one fair after two weeks. There was no surgical-related complication found. All patients noted the excellence satisfaction of the procedure. The minimal incision endoscopic-assisted cubital tunnel release has shown favorable outcomes with the cost-saving of simple instruments. However, a large prospective trial may be needed for further study.

Is Pseudomeningocele an Absolute Sign of Root Avulsion Brachial Plexus Injury?

BACKGROUND: The finding of pseudomeningocele from cervical myelogram is widely accepted as a pathognomonic sign for diagnosing root avulsion in brachial plexus injury. In general, motor power in this setting should be absent. However, in clinical practice, we observed that motor power in some patients was still preserved. The objective of this study is to evaluate the accuracy of pseudomeningocele from cervical myelogram for predicting root avulsion in brachial plexus injury. METHODS: We retrospectively reviewed 201 patients with brachial plexus injury from 2007-2011. Four patients were excluded due to open wound injury. Motor power of the key muscle of each nerve root was evaluated by skilled hand surgeons. All cervical myelogram was interpreted by radiologists. Sensitivities, specificities, positive predictive values and negative predictive values were calculated with 95% confidence interval. RESULTS: Thirty and 29% of pseudomeningocele occurred at C7 and C8 level, respectively. The sensitivity of pseudomeningocele of each root from C5 to T1 was low (range, 10-62%). The specificity was high only at C5 (91%) and T1 (96.2%). Over 20% of patients with pseudomeningocele at C6-8 levels had some motor function. The initial muscle power of these patients was M1 or M2 and 70% of them recovered to at least M3 at the final follow-up. CONCLUSIONS: Pseudomeningocele is not an absolute sign for diagnosing of root avulsion in brachial plexus injury due to its high false positive rate when compared with preoperative motor function of each root. Careful examination of the key muscle of each root is extremely crucial to prevent unnecessary operation on that cervical nerve root.

First dorsal metatarsal artery perforator flap to cover great toe defect.

BACKGROUND: There were very few options available for distal foot and toe defects that required a vascularized flap for coverage. As such, the use of a free flap was often justified in this region of the foot. The use of perforator flaps has created a new subset of local tissue transfer alternatives that increases the potential that the difficulties associated with microvascular tissue transfers could be avoided. The first dorsal metatarsal artery (FDMA) perforator flap was one variant of this new type of tissue transfer. The aim of this report was to describe our experience using FDMA perforator flap to cover great toe defect. METHODS: A standard FDMA flap from the dorsum of the foot was raised in reversed fashion based on the distal communicating branch or "perforator" from plantar foot circulation in two patients with great toe defect. RESULTS: Salvage of the great toe was achieved in both patients. FDMA perforator flap achieved both reconstructive goals, and the donor site closure can be successfully performed without tension. Donor site healing was achieved in both patients with no associated complications by the 1-year follow-up. CONCLUSIONS: FDMA flap can be successfully used as a local flap to cover distal foot and toe wounds. However, direct donor site closure can be problematic and may need skin graft.

End-to-Side Neurorrhaphy to Restore Elbow Flexion in Brachial Plexus Injury.

Background: End-to-side (ETS) neurorrhaphy is a controversial technique that is used for nerve transfer to achieve functional recovery. The advantage of this technique is the safety of donor nerve function. In this study, patients with extended upper-arm brachial plexus injury and significant hand weakness that did not meet the clinical criteria for end-to-end nerve transfer (Oberlin transfer) were treated by ETS neurorrhaphy to achieve biceps muscle reinnervation. Objective: To evaluate the outcome of ETS for biceps muscle reinnervation in brachial plexus injury patients. Material and Method: Thirteen patients with complete upper-arm and incomplete lower-arm brachial plexus injuries were treated by ETS of the motor branch of the biceps muscle to the ulnar or median nerves using the epineurial window technique. Results: Motor recovery was observed in nine of 13 patients. Good results were achieved in six patients who attained biceps motor power ≥ M3. No additional neurological deficits of the ulnar or median nerves were identified after the surgery. Conclusion: End-to-side neurorrhaphy is a viable treatment option for restoration of biceps muscle function if conventional end-to-end nerve transfer cannot be performed.

Neuropathic pain in brachial plexus injury.

BACKGROUND: In Thailand, brachial plexus injury is a common traumatic injury that affects the function of the upper extremity. The current treatments focus mainly on improving the motor and sensory function. Apart from the motor and sensory deficit, these patients usually suffer from pain. OBJECTIVE: The purpose of this study was to determine the prevalence and factors that relate to neuropathic pain in patients with brachial plexus injury. METHODS: We collected data from March 2008 to July 2011. The DN4 Questionnaire was used to diagnose neuropathic pain in 95 patients. RESULTS: The prevalence of neuropathic pain was as high as 76%. Majority of patients presented with hypoesthesia to pin prick, hypoesthesia to touch and numbness. Severity of neuropathic pain was significantly correlated with the type of brachial plexus injury. There was no difference between demographic characteristics of patients. CONCLUSION: Our study showed that the prevalence of neuropathic pain was high in brachial plexus injured patients. Therefore, surgeons should be aware of this common, yet underestimated, problem in brachial plexus injured patients.

Effectiveness and safety of home-based muscle electrical stimulator in brachial plexus injury patients.

OBJECTIVE: To evaluate the effectiveness and safety of home-based muscle electrical stimulation system in brachial plexus injury patients. MATERIAL AND METHOD: Forty brachial plexus injury patients underwent muscle electrical stimulation using a custom designed electrical stimulator. Effectiveness of the system, visual analog pain score, skin temperature, superficial skin condition, overallpatient satisfaction, and location of treatment preference were evaluated after the intervention. A follow-up telephone call was used to evaluate late-onset complications. RESULTS: Thirty-three men and seven women with an average age of 32 years were enrolled in the present study. According to our predefined definitions, 39 of 40 stimulation sessions were successfully completed, which resulted in a total system effectiveness of 97.5%. All patients tolerated the stimulation well. The average visual analog pain score was significantly decreased from 4 to 3 after the stimulation. There were no adverse incidents reported. The average patient satisfaction score was 7.8 out of 10. Thirty-five of 40 patients (88%) preferred to use home-based electrical stimulation vs. hospital-based treatment. CONCLUSION: The custom designed muscle electrical stimulator used in this study has demonstrated adequate effectiveness and safety for clinical home use for brachial plexus injury patients.

Distal radius volar locking plate design and associated vulnerability of the flexor pollicis longus.

PURPOSE: Flexor pollicis longus (FPL) tendon rupture is a well-documented complication related to the use of distal radius volar locking plates (VLPs). The final common pathway of flexor tendon rupture appears to involve implants prominent at the watershed line. We hypothesized that significant differences in VLP prominence exist between various plate designs. METHODS: Ten fresh frozen specimens were dissected to identify the path of the FPL in relationship to the distal radius at the watershed line. Five VLP designs were fixed to each specimen based on their anatomic fit, and slid distally until the distal edge of the plate reached the watershed line. The position of each fixed plate was evaluated by fluoroscopy. We used a 3-dimensional laser scanner to create computer models. The total surface area of plate prominence volar to the watershed line and the prominent area beneath the FPL were measured in the axial plane using computer software. RESULTS: At the watershed line, the FPL was located at 54% of the maximal width of the radius, as measured from its volar-ulnar corner. There were no significant differences in the location of plate fixation on lateral view radiographs according to the classification of Soong et al. The mean total surface area of plate prominence was 36 mm(2). The mean prominent area beneath the FPL was 10 mm2. Significant differences in plate prominence were noted for various designs. CONCLUSIONS: Despite optimal plate placement, various VLP designs were observed to have prominent profiles volar to the watershed line, to varying extents. CLINICAL RELEVANCE: The results raise concerns regarding interference between all of the analyzed VLP designs and the FPL. This study may help guide both implant design considerations and assist the surgeon in better understanding implant morphology as it relates to iatrogenic flexor tendon injury.

Adult brachial plexus injury: evaluation and management.

Adult traumatic brachial plexus injury involves injury of the C5-T1 spinal nerves. Common patterns of injury include "upper arm" and "total arm" types. The specific signs of preganglionic avulsion injury infer a poor prognosis for spontaneous recovery and surgery may be needed. Detailed preoperative evaluation is recommended for localization of the lesions. The treatment of upper arm type injury comprises restoration of elbow flexion and shoulder control. Good functional results may be achieved after multiple nerve transfers. The treatment of total arm type includes hand function reconstruction, in addition to shoulder and elbow treatment. Current options for hand function reconstruction include functioning free muscle transfers and nerve transfers.

Diaphragmatic height index: new diagnostic test for phrenic nerve dysfunction.

OBJECT: The diaphragmatic height index (DHI) was developed to measure the difference in diaphragm levels. The purpose of this study was to set definite DHI values and test the accuracy of these values for use as a new diagnostic test for phrenic nerve dysfunction. METHODS: All data for this study were obtained from medical charts and retrospectively reviewed. RESULTS: One hundred sixty-five patients with brachial plexus injury who had undergone nerve transfers between 2005 and 2008 were divided into Groups A and B. Group A consisted of 40 patients (mean age 28.0 years) who had sustained concomitant injury of the brachial plexus and phrenic nerves. Patients in Group A1 had right phrenic nerve injury and those in Group A2 had left phrenic nerve injury. Intraoperative direct electrical stimulation of the phrenic nerve was considered the gold standard in assessing nerve function in all patients with brachial plexus injury. Group B consisted of 125 patients (mean age 28.7 years) with brachial plexus injury and normal phrenic nerve function. Group C, the control group, consisted of 80 patients with nonbrachial plexus injury (mean age 34.0 years) who had undergone other kinds of orthopedic operations between April and June 2009. Standard posteroanterior chest radiographs were blindly interpreted using the Siriraj inhouse picture archiving and communication system in all 245 patients in the study. First, a reference line (R line) was drawn along the inferior endplate of T-10. Then, 2 lines (lines A and B) were drawn through the highest point of each diaphragm and parallel to the R line. The difference between these 2 lines divided by the height of T-10 was defined as the DHI. The cutoff points of the DHI for diagnosing right and left phrenic nerve dysfunction were analyzed with a receiver operating characteristic curve. The accuracy of these DHI values was then evaluated. The DHI in Group C was 0.64 ± 0.44, slightly higher than the DHI in Group B, with no significant difference. Diaphragmatic height indexes in Groups A1 and A2 were 2.0 ± 0.99 and -1.04 ± 0.83, respectively, which were significantly different from those in Groups B and C (p < 0.05). The cutoff point of the DHI for diagnosing right phrenic nerve dysfunction was > 1.1, and that for left phrenic nerve dysfunction was < 0.2. The sensitivity and specificity of right and left DHI values were 90.5% and 86.3%, and 94.7 and 88.3%, respectively. CONCLUSIONS: Data in this study show that diaphragm paralysis can be simply and reliably predicted by the DHI. Diaphragmatic height index values > 1.1 and < 0.2 are proposed as the new diagnostic test for right and left phrenic nerve dysfunction with a high degree of accuracy. This index is applicable in diagnosing phrenic nerve dysfunction that occurs concomitantly with brachial plexus injury or from other etiologies.

Comparison effectiveness of custom-made versus conventional aluminum splint for distal phalange injury.

BACKGROUND: Finger splint is a simple and common method for finger immobilization. The flexible aluminum foam-padded splint is a convenient off-the-shelf inexpensive splint. But there're some studies favor expensively custom-made thermoplastic splint due to its less likely result in treatment failure. Therefore the authors have modified the conventional aluminum finger splint in the foam-padded part to improve the fitting and compliance of the patients. OBJECTIVE: To compare the fitting of custom-made aluminum finger splint with conventional aluminum finger splint. MATERIAL AND METHOD: Sixty volunteers were randomized to apply 30 conventional or custom-made aluminum splints on 4th digit in non dominated hand for one week. The fitting of each splint was measured by displacement of the splint between initial placement and one week later. Patient satisfaction and pain was measured by visual analog score (VAS). RESULTS: The slip and deviation in custom-made group were less than the conventional group significantly (mean of slip 0.86 mm vs. 2.23 mm, p < 0.001, mean of deviation 1.1 degrees vs. 2.23 degrees,p < 0.001) but the longitudinal migration was not significantly difference between both groups (mean 1.6 mm in custom-made group vs. 1.46 mm in conventional group, p = 0.67). The patient satisfaction demonstrated no significant difference between both groups (mean VAS 7.76 in custom-made group vs. 7.3 in conventional group, p = 0.31). Two patients terminated from the present study before one week in custom-made group and one patient in the conventional group (6.67% vs. 3.33%, p = 0.554). CONCLUSION: The custom-made aluminum finger splint can improve the fitting to the finger pulp. However, patient satisfaction and compliance are not significantly different between both groups.