RESUMO
Three new halimane-type diterpenoids formosins A-C (1-3), and three clerodane-type diterpenoids formosins D-F (4-6), were isolated from the twigs of Excoecaria formosana. Their structures were assigned on the basis of spectroscopic data analysis. Compounds 1 and 4 showed moderate anti-microbial activities against Bacillus subtilis (MIC = 50 and 50 µg/mL, respectively). Compound 6 exhibited moderate anti-microbial activities against two strains of Helicobacter pylori (Hp-SS1 and ATCC 43504) with MIC values of 50 and 50 µg/mL, respectively.
RESUMO
Ten limonoids, toonacilianins A-J, and two norlimonoids, toonacilianins K and L, together with seven known compounds were isolated from the stems of Toona ciliata var. henryi (Meliaceae). Their structures were elucidated by spectroscopic analysis. Two compounds showed strong cytotoxic activities.
Assuntos
Antineoplásicos Fitogênicos/uso terapêutico , Limoninas/uso terapêutico , Meliaceae/química , Neoplasias/tratamento farmacológico , Fitoterapia , Adenocarcinoma/tratamento farmacológico , Antineoplásicos Fitogênicos/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Linhagem Celular Tumoral , Humanos , Leucemia Mieloide/tratamento farmacológico , Limoninas/isolamento & purificação , Limoninas/farmacologia , Neoplasias Pulmonares/tratamento farmacológico , Estrutura Molecular , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Caules de Planta/químicaRESUMO
Eleven new phragmalin-type limonoids, swietenitins N-X (1-11), together with a known one, epoxyfebrinin B (12), were isolated from the twigs of Swietenia macrophylla. The structures of the new compounds were established on the basis of spectroscopic methods, and that of compound 1 was confirmed by single-crystal X-ray diffraction. The stereochemistry of epoxyfebrinin B (12) was fully assigned in this study.
Assuntos
Limoninas/química , Meliaceae/química , Cristalografia por Raios X , Limoninas/isolamento & purificação , Espectroscopia de Ressonância Magnética , Conformação MolecularRESUMO
Six new oxygenated daphnane-type diterpenoids, trigoxyphins A-F (1-6), a phenanthrene-type diterpenoid, trigoxyphin G (7), and two known compounds were isolated from twigs of Trigonostemon xyphophylloides. Their structures were established using spectroscopic methods. Compounds 1 and 2 exhibited strong cytotoxic activity against HL60 (IC(50): 0.27 and 0.49 microM) and A549 (IC(50): 7.5 and 4.9 microM) tumor cell lines, respectively.
Assuntos
Diterpenos/isolamento & purificação , Medicamentos de Ervas Chinesas/isolamento & purificação , Euphorbiaceae/química , Fenantrenos/isolamento & purificação , Diterpenos/química , Diterpenos/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/farmacologia , Células HL-60 , Humanos , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Fenantrenos/química , Fenantrenos/farmacologia , Caules de Planta/químicaRESUMO
Limonoids, mulavanins A-E (1-5), along with four known compounds, were isolated from whole plants of Munronia delavayi. Their structures were elucidated by spectroscopic methods. Two of the compounds showed modest antifungal activity.
Assuntos
Anti-Infecciosos/química , Anti-Infecciosos/farmacologia , Limoninas/química , Limoninas/farmacologia , Meliaceae/química , Anti-Infecciosos/isolamento & purificação , Bactérias/efeitos dos fármacos , Fungos/efeitos dos fármacos , Limoninas/isolamento & purificação , Análise EspectralRESUMO
Eleven new mexicanolide-type limonoids, swietmanins A-I (1-4, 7-11), 2-hydroxy-3-O-isobutyrylproceranolide (5), 2-hydroxy-3-O-benzoylproceranolide (6), and a new andirobin-type limonoid, swietmanin J (12), together with 19 known compounds were isolated from the fruits of Swietenia mahagoni. Their structures were established on the basis of spectroscopic methods. These compounds were evaluated against a small panel of microorganisms.
Assuntos
Antibacterianos/isolamento & purificação , Antifúngicos/isolamento & purificação , Medicamentos de Ervas Chinesas/química , Limoninas/isolamento & purificação , Meliaceae/química , Antibacterianos/química , Antibacterianos/farmacologia , Antifúngicos/química , Antifúngicos/farmacologia , Bactérias/efeitos dos fármacos , Medicamentos de Ervas Chinesas/isolamento & purificação , Medicamentos de Ervas Chinesas/farmacologia , Frutas/química , Fungos/efeitos dos fármacos , Limoninas/química , Limoninas/farmacologia , Testes de Sensibilidade Microbiana , Estrutura Molecular , Ressonância Magnética Nuclear BiomolecularRESUMO
Sixteen new D-ring-opened phragmalin limonoid orthoesters, swietenitins A-M (1-6, 8, 10, 12-16), 2-acetoxyswietenialide D (7), 2,11-diacetoxyswietenialide D (9), and 11-deoxyswietenialide D (11), and four known compounds were isolated from the twigs of Swietenia macrophylla. The structures of 1-16 were established on the basis of spectroscopic methods, and 1 and 2 were confirmed by single-crystal X-ray diffraction. The (1)H NMR-based conformational analysis on the epimeric compounds 1 and 2 provided a general approach to determine the absolute configuration of the 2,3-epoxy-2-methylbutyryloxy unit at C-3 borne by a large group of the known phragmalin-type limonoid orthoesters.
