RESUMO
We tested the fluoroquinolone susceptibility of 499 Salmonella enterica isolates collected from travelers returning to Finland during 2003-2007. Among isolates from travelers to Thailand and Malaysia, reduced fluoroquinolone susceptibility decreased from 65% to 22% (p = 0.002). All isolates showing nonclassical quinolone resistance were from travelers to these 2 countries.
Assuntos
Antibacterianos/farmacologia , Farmacorresistência Bacteriana , Fluoroquinolonas/farmacologia , Salmonella enterica/efeitos dos fármacos , Viagem , Anti-Infecciosos/farmacologia , Ciprofloxacina/farmacologia , Finlândia , Humanos , Testes de Sensibilidade Microbiana , Ácido Nalidíxico/farmacologia , Infecções por Salmonella/microbiologia , Salmonella enterica/classificação , Salmonella enterica/isolamento & purificação , SorotipagemRESUMO
Human intestinal Enterococcus spp. was monitored during a 2-y period after 7 d clindamycin treatment. Consecutive faecal samples were collected from 8 healthy volunteers, 4 of whom had received clindamycin. After treatment, the number of enterococcal colonies was diminished and species variation extended. Erythromycin and clindamycin resistance increased from 19% to 69% and 0% to 67%, respectively. Elevated resistance levels lasted up to 9 months and erm(B) was detected in samples up to 6 months. Our results show that the clindamycin treatment had a prolonged impact on resistance and species variation.
Assuntos
Antibacterianos/farmacologia , Clindamicina/farmacologia , Farmacorresistência Bacteriana/genética , Enterococcus/efeitos dos fármacos , Intestinos/microbiologia , Adulto , Proteínas de Bactérias/genética , Enterococcus/genética , Enterococcus/isolamento & purificação , Fezes/microbiologia , Feminino , Humanos , Estudos Longitudinais , Masculino , Metiltransferases/genética , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Reação em Cadeia da PolimeraseRESUMO
We studied in vitro activity against invasive viridans group streptococci (VGS) of penicillin and 4 newer antibiotics, i.e. telithromycin, linezolid, levofloxacin and quinupristin-dalfopristin. Also 7 other antibiotics were tested. Antibiotic susceptibility of 263 VGS blood isolates, collected from southwest Finland during a 12-y period was determined. We wished to discover whether there is an increasing trend of antimicrobial resistance among VGS in Finland. Our results showed that penicillin is still a good choice for treating VGS infections based on the considerably low resistance percentage, 2.3%. Also newer antibiotics showed good in vitro activity: susceptibilities for telithromycin, linezolid and levofloxacin were 100%, 98.9% and 94.6%, respectively. However, quinupristin-dalfopristin was not as effective as described in previous studies, with only 57% susceptibility.
Assuntos
Infecções Estreptocócicas/microbiologia , Estreptococos Viridans/efeitos dos fármacos , Contagem de Colônia Microbiana/métodos , Testes de Sensibilidade a Antimicrobianos por Disco-Difusão/métodos , Farmacorresistência Bacteriana Múltipla , Finlândia , Humanos , Infecções Estreptocócicas/sangue , Estreptococos Viridans/isolamento & purificaçãoAssuntos
Antibacterianos/farmacologia , Cetolídeos/farmacologia , Streptococcus pneumoniae/efeitos dos fármacos , Streptococcus pneumoniae/genética , Eletroforese em Gel de Campo Pulsado , Finlândia , Humanos , Testes de Sensibilidade Microbiana , Epidemiologia Molecular , Análise de Sequência de DNA , Streptococcus pneumoniae/classificaçãoRESUMO
We describe the emergence of a new quinolone resistance pattern in Salmonella enterica isolates from Southeast Asia. These isolates are susceptible to nalidixic acid but exhibit reduced susceptibility to ciprofloxacin. The increase of such strains may threaten the value of the nalidixic acid disk test to screen for reduced fluoroquinolone susceptibility in salmonellas.
