RESUMO
Heidelberg Spectralis infrared video imaging provides a diagnostic modality for the assessment of dynamic torsional instability of the eyes. It accurately detects monocular changes in both vertical and torsional eye position as fixation is switched from one eye to the other without the need for illuminating either eye. Heidelberg Spectralis infrared video imaging is useful for depicting the subtle torsional components of dissociated vertical divergence, latent nystagmus in patients with infantile esotropia.
Assuntos
Diagnóstico por Imagem/métodos , Técnicas de Diagnóstico Oftalmológico , Exotropia/diagnóstico , Nistagmo Patológico/diagnóstico , Anormalidade Torcional/diagnóstico , Adulto , Feminino , Fixação Ocular , Humanos , Raios Infravermelhos , Pessoa de Meia-Idade , Músculos Oculomotores/patologia , Gravação em VídeoAssuntos
Albinismo/genética , Cromossomos Humanos X/genética , Cromossomos Humanos Y/genética , Mosaicismo , Doenças Retinianas/genética , Epitélio Pigmentado da Retina/patologia , Translocação Genética , Pré-Escolar , DNA/genética , Análise Mutacional de DNA , Proteínas do Olho/genética , Feminino , Humanos , Glicoproteínas de Membrana/genética , Mutação , Doenças Retinianas/congênito , Doenças Retinianas/diagnósticoRESUMO
The purpose of this article is to demonstrate the utility of the large spot size (LSS) setting using a binocular laser indirect delivery system for peripheral ablation in children. One patient with bilateral retinopathy of prematurity received photocoagulation with standard spot size burns placed adjacently to LSS burns. Using a pixel analysis program called Image J on the Retcam picture, the areas of each retinal spot size were determined in units of pixels, giving a standard spot range of 805 to 1294 pixels and LSS range of 1699 to 2311 pixels. Additionally, fluence was calculated using theoretical retinal areas produced by each spot size: the standard spot setting was 462 mJ/mm2 and the LSS setting was 104 mJ/mm2. For eyes with retinopathy of prematurity, our study shows that LSS laser indirect delivery halves the number of spots required for treatment and reduces fluence by almost one-quarter, producing more uniform spots.
Assuntos
Fotocoagulação a Laser/métodos , Pars Planite/cirurgia , Telangiectasia Retiniana/cirurgia , Vasculite Retiniana/cirurgia , Retinopatia da Prematuridade/cirurgia , Adolescente , Criança , Feminino , Humanos , Lactente , Recém-Nascido , Fotocoagulação a Laser/instrumentação , Masculino , Oftalmoscópios , Estudos Retrospectivos , Resultado do Tratamento , Acuidade Visual/fisiologiaRESUMO
Angiogenesis is a common factor in the pathogenesis of cancer and in exudative age-related macular degeneration (AMD). Therefore, angiogenesis inhibition has been developed as a therapeutic strategy. We report 2 cases of recurrent exudative AMD in which oral sorafenib, a tyrosine kinase inhibitor approved for cancer, was added to intravitreal ranibizumab, an antibody to vascular endothelial growth factor. These 2 patients were followed up by determination of visual acuity, fluorescein angiography, fundoscopy, and optical coherence tomography. The visual acuity of 1 patient improved from 20/70 to 20/60 while he was receiving sorafenib therapy; that of the other did not. Marked improvement was noted in both patients on optical coherence tomography. Additionally, both patients appeared to receive some benefit when low-dose oral sorafenib was used as monotherapy after its initial addition to ranibizumab therapy. Randomized trials of adding sorafenib to standard therapy for patients with neovascular AMD should be considered.
Assuntos
Anticorpos Monoclonais/administração & dosagem , Benzenossulfonatos/administração & dosagem , Degeneração Macular/tratamento farmacológico , Inibidores de Proteínas Quinases/administração & dosagem , Piridinas/administração & dosagem , Idoso de 80 Anos ou mais , Anticorpos Monoclonais Humanizados , Quimioterapia Combinada , Angiofluoresceinografia , Humanos , Degeneração Macular/diagnóstico por imagem , Masculino , Niacinamida/análogos & derivados , Compostos de Fenilureia , Radiografia , Ranibizumab , Recidiva , SorafenibeAssuntos
Neoplasias da Coroide/patologia , Neoplasias Pulmonares/patologia , Linfoma de Células B/patologia , Linfoma Difuso de Grandes Células B/patologia , Adulto , Antígenos CD20/metabolismo , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biomarcadores Tumorais/metabolismo , Neoplasias da Coroide/tratamento farmacológico , Angiofluoresceinografia , Humanos , Técnicas Imunoenzimáticas , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/metabolismo , Linfoma de Células B/tratamento farmacológico , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Masculino , Tomografia Computadorizada por Raios XRESUMO
OBJECTIVE: To report retinopathy following exposure to light from a commercially available class 3A green laser pointer. METHODS: A 55-year-old woman with a ring melanoma was scheduled for enucleation. The eye (visual acuity 20/20) had a healthy-appearing macular retina. The retina was exposed to light from a commercially available class 3A green laser: 60 seconds to the fovea, 5 minutes to a site 5 degrees below the fovea, and 15 minutes to a site 5 degrees superior to the fovea. Color photographs were obtained before and after exposure. The eye was enucleated 20 days after exposure. RESULTS: Laser power measurements averaged less than 5 mW. Retinopathy was observed 24 hours after laser exposure. This was characterized by a yellowish discoloration at the level of the retinal pigment epithelium (RPE) in the subfoveal region and at the site superior to the macula where the retina received 15 minutes of laser exposure. Each site developed granular changes at the level of the RPE within 5 days of exposure. Histologic study showed RPE damage in the exposed subfoveal and parafoveal regions. CONCLUSION: A class 3A green laser pointer caused visible retinopathy in the human eye with exposures as short as 60 seconds.
