[Effect of diacarb on the carbonic anhydrase activity in the blood and gastric mucosa and pepsinogen concentration in the gastric mucosa of the rat]. / Vliianie diakarba na aktivnost' karbonangidrazy v krovi i slizistoi obolochke zheludka i na soderzhanie pepsinogena v slizistoi zheludka krys.

It was established that the activity of blood and gastric mucosa carboanhydrase increased after the introduction of food irritant (milk) into the stomach, as well as after the subcutaneous injection of histamine. This was accompanied by the increase of pepsinogen content in the gastric mucosa. When introduced into the stomach before the food irritant or histamine, acetazolamide inhibited blood and gastric mucosa carboanhydrase and reduced the content of pepsinogen in the gastric mucosa. Oral administration of acetazolamide for 5 days resulted in a more remarkable inhibition of blood and gastric mucosa carboanhydrase and in a drastically reduced content of pepsinogen in the gastric mucosa. The rate of pepsinogen biosynthesis by the gastric mucosa seems to depend on the activity of carboanhydrase in blood and in the gastric mucosa.

[Polypeptides isolated from the gastric mucosa and their effect on pepsin biosynthesis by gastric glands]. / Polipeptidy, vydelennye iz slizistoi obolochki zheludka, i ikh deistvie na biosintez pepsina zhelezami zheludka.

It was found in experiments on 90 rats that polypeptides A, B and C (with a molecular mass of 2200-2800) isolated from the gastric mucosa have the ability to stimulate pepsin biosynthesis by the gastric glands. Application of the polypeptides did not result in the concurrent rise of proteolytic and milk-curdling activity. Pepsin and trypsin promoted the release from polypeptide B of low-molecular weight peptides which also stimulated pepsin biosynthesis.