[Adverse reactions of tanshinone II(A) sodium sulfonate injection in treating 18 cases: an analysis of clinical features].

OBJECTIVE: To explore clinical features the adverse reactions of Tanshinone II(A) Sodium Sulfonate Injection (T II(A) SSI) and their reasons, thus providing reference for rational medication. METHODS: The literatures on adverse reactions and incompatibilities of T II(A) SSI were retrieved (domestic medical journals from January 2000 to December 2011) and statistically analyzed. RESULTS: In the 18 cases of adverse drug reaction (ADR), the clinical manifestations of T II(A) SSI induced adverse reactions were various, involving reactions of appendages and the neuromuscular system (each accounting for 50%). The elderly and women were mainly involved. Many organs and systems were involved. There existed more incompatibilities. CONCLUSION: The medical workers should pay special attention to T II(A) SSI induced adverse reactions, thus avoiding recurrence of ADR, evading risks, and ensuring safe and rational medication.

[Study of factors associated with subclinical chorioamnionitis in term pregnancy].

OBJECTIVE: To investigate the effects of various factors upon subclinical chorioamnionitis (SCCAS) during pregnancy and delivery. METHODS: A total of 796 cases of pregnancy in full-term birth at our hospital from December 2006 to December 2008 were reviewed. The data of maternal age, gravidity, parity, gestational age, prenatal care, history of vaginitis, premature rupture of membranes, occupation, educational status and delivery mode were recorded. And then the relationship between one of them and chorioamniotis were analyzed by chi(2) test. RESULTS: The overall incidence of SCCAS was 39.95% in full-term birth. The pregnant women, who had no prenatal care or no occupation, or had a history of vaginitis or premature rupture of membranes, were found to have a higher incidence (P < 0.05 or P < 0.01). However, there were no statistical significance (P > 0.05) between SCCAS and other seven factors, such as gravida age, gravidity, parity, gestational age, educational status, delivery mode and living conditions. CONCLUSION: Women with full-term birth, even in the absence of symptoms, may have already suffered from acute or chronic chorioamnionitis. The incidence is associated with prenatal care, history of vaginitis and premature rupture of membranes.