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1.
Math Biosci Eng ; 20(5): 9246-9267, 2023 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-37161241

RESUMO

The integration of the Internet of Bio Nano Things (IoBNT) with artificial intelligence (AI) and molecular communications technology is now required to achieve eHealth, specifically in the targeted drug delivery system (TDDS). In this work, we investigate an analytical framework for IoBNT with Forster resonance energy transfer (FRET) nanocommunication to enable intelligent bio nano thing (BNT) machine to accurately deliver therapeutic drug to the diseased cells. The FRET nanocommunication is accomplished by using the well-known pair of fluorescent proteins, EYFP and ECFP. Furthermore, the proposed IoBNT monitors drug transmission by using the quenching process in order to reduce side effects in healthy cells. We investigate the IoBNT framework by driving diffusional rate models in the presence of a quenching process. We evaluate the performance of the proposed framework in terms of the energy transfer efficiency, diffusion-controlled rate and drug loss rate. According to the simulation results, the proposed IoBNT with the intelligent bio nano thing for monitoring the quenching process can significantly achieve high energy transfer efficiency and low drug delivery loss rate, i.e., accurately delivering the desired therapeutic drugs to the diseased cell.


Assuntos
Internet das Coisas , Telemedicina , Transferência Ressonante de Energia de Fluorescência , Inteligência Artificial , Internet
2.
IET Nanobiotechnol ; 9(6): 331-41, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26647808

RESUMO

Mobile ad hoc molecular nanonetwork (MAMNET) is a new paradigm for the realisation of future nanonetworks. In MAMNET, transmission of nanoscale information from nanomachine to infostation is based on collision and adhesion. In this study, the authors develop a realistic framework for encompassing the electronic structure of the neurotransmitter in the process of transmitting nanoscale information at a single input single output nanonetwork. Nanonetwork performance is evaluated in terms of average packet delay, throughput and incurred traffic rate. Numerical results demonstrate the influence of the neurotransmitter's electronic structure over the performance of nanonetworks.


Assuntos
Materiais Biomiméticos/química , Computadores Moleculares , Nanopartículas/química , Redes Neurais de Computação , Neurônios/fisiologia , Neurotransmissores/metabolismo , Potenciais de Ação/fisiologia , Animais , Humanos , Modelos Neurológicos , Nanopartículas/ultraestrutura , Rede Nervosa/fisiologia , Transmissão Sináptica/fisiologia
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