Psychometric Properties of the Spanish Version of Breast Cancer and Lymphedema Symptom Experience Index.

BACKGROUND: Lymphedema is a common late and chronic adverse effect of breast cancer treatment. This study aimed to translate and evaluate the psychometric properties of the BCLE-SEI Spanish version with Spanish-speaking breast cancer patients. METHOD: 286 patients were recruited (2018 to 2020), from the Hospital Universitario Central de Asturias. Data analysis included descriptive statistics; internal consistency and test-retest reliability; principal component analysis and exploratory factor analysis; average variance extracted; and receiver operating characteristic curves. RESULTS: No semantic modifications to items were needed. The scores of the instrument demonstrated excellent internal consistency (Cronbach´s alpha = .95-.97; McDonald´s omega = .96-.98) and test-retest reliability (r = .78-.87, n = 29). A significant difference was observed between the lymphedema group and non-lymphedema group (p < .001) in terms of total scale, symptom occurrence (p < .001), symptom distress in the physical-functional (p < .001), and psychosocial dimension (p < .001). Principal component analysis for symptom occurrence revealed a unidimensional factor and two factors were identified for symptom distress via exploratory factor analysis, the two of which explained 45.71% and 54.77% of the total sample variance, respectively. CONCLUSIONS: This study provided initial evidence to support the psychometric properties of the BCLE-SEI Spanish version.

Psychometric Properties of the Spanish Version of Breast Cancer and Lymphedema Symptom Experience Index / Propiedades Psicométricas de la Versión Española del Breast Cancer andLymphedema Symptom Experience Index

Background: Lymphedema is a common late and chronic adverse effectof breast cancer treatment. This study aimed to translate and evaluate thepsychometric properties of the BCLE-SEI Spanish version with Spanish-speaking breast cancer patients. Method: 286 patients were recruited(2018 to 2020), from the Hospital Universitario Central de Asturias. Dataanalysis included descriptive statistics; internal consistency and test-retestreliability; principal component analysis and exploratory factor analysis;average variance extracted; and receiver operating characteristic curves.Results: No semantic modifications to items were needed. The scores ofthe instrument demonstrated excellent internal consistency (Cronbach’salpha = .95-.97; McDonald’s omega = .96-.98) and test-retest reliability(r = .78-.87, n = 29). A significant difference was observed between thelymphedema group and non-lymphedema group (p < .001) in terms of totalscale, symptom occurrence (p < .001), symptom distress in the physical-functional (p < .001), and psychosocial dimension (p < .001). Principalcomponent analysis for symptom occurrence revealed a unidimensionalfactor and two factors were identified for symptom distress via exploratoryfactor analysis, the two of which explained 45.71% and 54.77% of the totalsample variance, respectively. Conclusions: This study provided initialevidence to support the psychometric properties of the BCLE-SEI Spanishversion.

Antecedentes: el linfedemaes una complicación tras el cáncer de mama. El objetivo fue evaluar laspropiedades psicométricas de la versión española BCLE-SEI en mujeresdiagnosticadas de cáncer de mama que hablaban español. Método:participaron 286 pacientes (2018 a 2020) del Hospital UniversitarioCentral de Asturias. El análisis de datos incluyó estadísticos descriptivos;consistencia interna y fiabilidad test-retest, análisis de componentesprincipales y análisis factorial exploratorio; varianza media extraída;y curvas de características operativas del receptor. Resultados: no senecesitaron modificaciones semánticas en los ítems. El instrumentodemostró excelente consistencia interna (alfa de Cronbach = 0,95-0,97;omega de McDonald = .96-.98) y fiabilidad test-retest (r = 0,78-0,87; n =29). Se observaron diferencias significativas entre grupos linfedema y sinlinfedema (p < .001) en las escalas total, de síntomas (p < .001), físico-funcional (p < .001) y psicosocial (p < .001). El análisis de componentesprincipales para la “aparición de síntomas” reveló un factor unidimensionaly se identificaron dos factores para la “angustia por síntomas” a través delanálisis factorial exploratorio, explicando el 45,71% y el 54,77% de lavarianza total de la muestra, respectivamente. Conclusiones: la versiónespañola de BCLE-SEI mostró adecuadas propiedades psicométricas.

Predicción de riesgo de cáncer de mama en mujeres sanas de población española basado en el estudio de variantes genéticas / Prediction of cancer risk based on study of genetic variants in healthy women in the Spanish population

Objetivo: Estratificación de la población general con base en las variantes genotípicas para seleccionar a aquellas mujeres de alto riesgo a desarrollar un cáncer de mama que puedan ser candidatas a un seguimiento individualizado. Material y métodos: Se ha realizado un estudio caso-control en 856 mujeres con cáncer de mama y 839 mujeres controles de la población general pareadas por edad, analizando la asociación entre el riesgo a desarrollar cáncer de mama y un grupo de variantes basado en 76 polimorfismos de un cambio de base (SNP) de susceptibilidad. Resultados: Se han establecido 2curvas de casos y controles con base en las odds ratio (OR) genotípicas que diferencian las 2poblaciones con significación estadística (p = 2,293×10-15). Asimismo, se ha estratificado la población de casos y controles e identificado un 14% de la población que se encontraría en el grupo de alto riesgo con una OR > 2 (> 25% probabilidades de desarrollar un cáncer de mama). Este grupo sería candidato a un seguimiento individualizado. Conclusiones: El Polygenic Risk Score es un predictor del riesgo del cáncer de mama independiente que puede ayudar a seleccionar mujeres con alto riesgo para establecer medidas de seguimiento y tratamiento individualizado en función del riesgo genético

Objective: To stratify the general population based on genotypic variants in order to select women at high risk of breast cancer who could be candidates for individualized follow-up. Material and methods: We performed a case-control study in 856 women with breast cancer and 839 aged-matched control women from the general population. We analysed the association between the risk of developing breast cancer and a group of variants based on 76 susceptibility single nucleotide polymorphisms. Results: Two case-control curves were established based on genotypic odds ratios (OR) that differentiated the 2populations with statistical significance (P=2.293×10-15). Stratification of the case-control population showed that 14% of the population would be at high risk, with an OR>2 (> 25% probability of developing breast cancer). Persons in this group would be candidates for individualized follow-up. Conclusions: The Polygenic Risk Score is an independent predictor of breast cancer risk that may help to select women at high risk, with a view to establishing individualised follow-up and treatment according to genetic risk

Calidad de vida relacionada con la salud y peso corporal en mujeres supervivientes al cáncer de mama / Health-related quality of life and body weight in female survivors of breast cancer

Objetivo. La calidad de vida relacionada con la salud (CVRS) representa la percepción del bienestar en varias esferas. El objetivo principal de este trabajo fue explorar la asociación entre la masa corporal y la CVRS de las mujeres en seguimiento de cáncer de mama, tanto en la esfera mental como física. Método. Estudio transversal sobre pacientes a seguimiento por cáncer de mama de la Unidad de Patología Mamaria del Hospital Universitario Central de Asturias. Se incluyeron 277 mujeres a las que se les realizó el cuestionario SF-12 de CVRS. Se midió el índice de masa corporal con métodos estandarizados. Las esferas física y mental del SF-12 se estandarizaron según la norma española (media 50 puntos, desviación estándar 10). La asociación entre el componente físico y mental de la CVRS y el peso corporal se analizó utilizando regresiones lineales ajustadas a los principales confusores. Resultados. Se evidenció un 32,5% de sobrepeso y un 10,1% de obesidad. La media en la esfera física fue de 46,6 (intervalo de confianza al 95% 45,7-47,7) y la mental, de 33,3 (intervalo de confianza al 95% 45,5-47,7). El exceso de peso se asoció de forma estadísticamente significativa con una menor puntuación en la esfera física. Conclusiones. En comparación con la CVRS de la población general española, la de las pacientes con cáncer de mama fue menor tanto en la esfera física como en la mental. La obesidad se relacionó con una menor puntuación física, por lo que hay que promover el control del peso corporal

Objective. Health-related quality of life (HRQL) is the perception of wellbeing in different dimensions. The main objective of this study was to evaluate the relationship between body weight and the mental and physical domains of HRQL in women with breast cancer. Method. A cross-sectional study was conducted in 277 women with breast cancer followed up by the Breast Cancer Unit of the Central University Hospital of Asturias. All participants completed the SF-12 questionnaire. Body mass index was measured using standardised methods. The mental and physical domains of the SF-12 were standardised to the Spanish general population (average 50 points, standard deviation 10). The association between the physical and mental components of HRQL and body weight was analysed using linear regressions adjusted to the main confounders. Results. A total of 32.5% of the patients were overweight and 10.1% were obese. The average score was 46.6 (95% confidence interval 45.7-47.7) on the physical domain and 33.3 (95% confidence interval 45.5-47.7) on the mental domain. Excess weight showed a statistically significant association with a lower score in the physical domain. Conclusions. In comparison with HRQL in the general Spanish population, HRQL in women with breast cancer was lower in both the physical and mental domains. Obesity was associated with lower physical scores. Consequently, control of body weight is recommended

MicroRNA deregulation in triple negative breast cancer reveals a role of miR-498 in regulating BRCA1 expression.

Emerging evidence suggests that BRCA1 pathway contributes to the behavior of sporadic triple negative breast cancer (TNBC), but little is known about the mechanisms underlying this association. Considering the central role that microRNAs (miRNAs) play in gene expression regulation, the aim of this study was to identify miRNAs specifically deregulated in TNBC and investigate their involvement in BRCA1 regulation. Using locked nucleic acid (LNA)-based microarrays, expression levels of 1919 miRNAs were measured in paraffin-embedded tissues from 122 breast tumors and 11 healthy breast tissue samples. Differential miRNA expression was explored among the main subtypes of breast cancer, and 105 miRNAs were identified as specific for triple negative tumors. In silico prediction revealed that miR-498 and miR-187-5p target BRCA1, and these results were confirmed by luciferase reporter assay. While miR-187-5p was found overexpressed in a luminal B cell line, miR-498 was highly expressed in a triple negative cell line, Hs578T, and its expression was negatively correlated with the levels of BRCA1. We functionally demonstrated that miR-498 inhibits BRCA1 in breast cancer cell lines, and showed that inhibition of miR-498 led to reduced proliferation in the triple negative cell line Hs578T. Our results indicate that miR-498 regulates BRCA1 expression in breast cancer and its overexpression could contribute to the pathogenesis of sporadic TNBC via BRCA1 downregulation.

[Single port laparoscopic colostomy using the glove technique]. / Colostomía laparoscópica por puerto único con técnica de guante.

The single port surgery with glove technique is a novel process, suitable to the present day economic and technological moment. Colostomies are surgical interventions suitable to its application. We describe the surgical method and outcome of patients who underwent colostomy by single port glove technique within the years 2011 and 2012, in two hospitals in Asturias, Spain. We carried out six sigmoid colostomies. Four patients had tumoral pathology, another a perineal necrotizing fasciitis, and the sixth, a patient with Crohn's disease and complex perianal fistulas. The average age of the patients, four men and two women, was 54 years (range 42-67 years). The average intervention time was 42 minutes (range 30-65 minutes). There were no complications during the surgery or in the postoperative period. In our facilities material expenditure was reduced to half as regards other conventional single port devices. The glove technique represents the most economic and least invasive approach for the surgical procedure of stomas, in our experience considered a simple, safe and easily reproducible technique.

Colostomía laparoscópica por puerto único con técnica de guante / Single port laparoscopic colostomy using the glove technique

La cirugía por puerto único con técnica de guante (glove port) es un abordaje adecuado al momento económico y tecnológico que vivimos. Entre las intervenciones susceptibles de su aplicación está la realización de colostomías. Describimos la técnica quirúrgica y resultados de los pacientes a los que se realizó colostomía por puerto único con técnica de guante, a lo largo de los años 2011 y 2012, en dos hospitales de Asturias, España. Realizamos seis colostomías sigmoideas. Cuatro pacientes presentaban enfermedad tumoral, otro caso fue por una fascitis necrosante perineal, y el sexto un paciente con enfermedad de Crohn y fístulas perianales complejas. La edad media de los pacientes, cuatro hombres y dos mujeres, fue de 54 años (rango 42-67 años). El tiempo medio de intervención fue de 42 minutos (rango 30-65 minutos). No hubo complicaciones durante la cirugía ni en el postoperatorio. En nuestro medio, el gasto en material se redujo a la mitad con respecto a otros dispositivos convencionales de puerto único. La técnica de guante representa el abordaje por puerto único más económico y mínimamente invasivo para la realización de estomas, siendo en nuestra experiencia una técnica sencilla, segura y fácilmente reproducible.

The single port surgery with glove technique is a novel process, suitable to the present day economic and technological moment .Colostomies are surgical interventions suitable to its application. We describe the surgical method and outcome of patients who underwent colostomy by single port glove technique within the years 2011 and 2012, in two hospitals in Asturias, Spain. We carried out six sigmoid colostomies. Four patients had tumoral pathology, another a perineal necrotizing fasciitis, and the sixth, a patient with Crohn's disease and complex peri-anal fistulas. The average age of the patients, four men and two women, was 54 years (range 42-67 years). The average intervention time was 42 minutes (range 30-65 minutes). There were no complications during the surgery or in the postoperative period. In our facilities material expenditure was reduced to half as regards other conventional single port devices. The glove technique represents the most economic and least invasive approach for the surgical procedure of stomas, in our experience considered a simple, safe and easily reproducible technique.

Colostomía laparoscópica por puerto único con técnica de guante / Single port laparoscopic colostomy using the glove technique

La cirugía por puerto único con técnica de guante (glove port) es un abordaje adecuado al momento económico y tecnológico que vivimos. Entre las intervenciones susceptibles de su aplicación está la realización de colostomías. Describimos la técnica quirúrgica y resultados de los pacientes a los que se realizó colostomía por puerto único con técnica de guante, a lo largo de los años 2011 y 2012, en dos hospitales de Asturias, España. Realizamos seis colostomías sigmoideas. Cuatro pacientes presentaban enfermedad tumoral, otro caso fue por una fascitis necrosante perineal, y el sexto un paciente con enfermedad de Crohn y fístulas perianales complejas. La edad media de los pacientes, cuatro hombres y dos mujeres, fue de 54 años (rango 42-67 años). El tiempo medio de intervención fue de 42 minutos (rango 30-65 minutos). No hubo complicaciones durante la cirugía ni en el postoperatorio. En nuestro medio, el gasto en material se redujo a la mitad con respecto a otros dispositivos convencionales de puerto único. La técnica de guante representa el abordaje por puerto único más económico y mínimamente invasivo para la realización de estomas, siendo en nuestra experiencia una técnica sencilla, segura y fácilmente reproducible.(AU)

The single port surgery with glove technique is a novel process, suitable to the present day economic and technological moment .Colostomies are surgical interventions suitable to its application. We describe the surgical method and outcome of patients who underwent colostomy by single port glove technique within the years 2011 and 2012, in two hospitals in Asturias, Spain. We carried out six sigmoid colostomies. Four patients had tumoral pathology, another a perineal necrotizing fasciitis, and the sixth, a patient with Crohns disease and complex peri-anal fistulas. The average age of the patients, four men and two women, was 54 years (range 42-67 years). The average intervention time was 42 minutes (range 30-65 minutes). There were no complications during the surgery or in the postoperative period. In our facilities material expenditure was reduced to half as regards other conventional single port devices. The glove technique represents the most economic and least invasive approach for the surgical procedure of stomas, in our experience considered a simple, safe and easily reproducible technique.(AU)

Colostomía laparoscópica por puerto único con técnica de guante. / [Single port laparoscopic colostomy using the glove technique].

The single port surgery with glove technique is a novel process, suitable to the present day economic and technological moment. Colostomies are surgical interventions suitable to its application. We describe the surgical method and outcome of patients who underwent colostomy by single port glove technique within the years 2011 and 2012, in two hospitals in Asturias, Spain. We carried out six sigmoid colostomies. Four patients had tumoral pathology, another a perineal necrotizing fasciitis, and the sixth, a patient with Crohns disease and complex perianal fistulas. The average age of the patients, four men and two women, was 54 years (range 42-67 years). The average intervention time was 42 minutes (range 30-65 minutes). There were no complications during the surgery or in the postoperative period. In our facilities material expenditure was reduced to half as regards other conventional single port devices. The glove technique represents the most economic and least invasive approach for the surgical procedure of stomas, in our experience considered a simple, safe and easily reproducible technique.

Pseudocarcinoma de colon / Pseudo-carcinoma of the colon

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