Dermatitis granulomatosa intersticial y tocilizumab: ¿es este un tratamiento de utilidad para esta dermatosis? / Interstitial Granulomatous Dermatitis and Tocilizumab: Is This Treatment Useful for This Skin Condition?

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Changes in arterial partial pressure and end-expired pressure of carbon dioxide in prepubescent and adult bitches undergoing ovariohysterectomy by videolaparoscopy or conventional laparotomy / Variações nas pressões parciais arteriais e expiradas de dióxido de carbono em cadelas pré-púberes e adultas submetidasà ovário histerectomiavídeo laparoscópica ou convencional

ABSTRACT: This paper aimed to determine arterial partial pressure of carbon dioxide (PaCO2), end-expired CO2 pressure (ETCO2), and the difference between arterial and end-expired CO2 pressure (Pa - ETCO2) in prepubescent and adult bitches undergoing videolaparoscopic or conventional ovariohyterectomy (OH). Forty bitches were randomly assigned to four groups: Conventional Adult (CA), Conventional Pediatric (CP), Videolaparoscopic Adult (VA) and Videolaparoscopic Pediatric (VP). Pulse rate (PR), respiratory rate (RR), systolic, mean, and diastolic arterial pressures (SAP, MAP, DAP), ETCO2, peak inspiratory pressure (PIP), pH, arterial partial pressure of oxygen (PaO2), PaCO2, base excess (BE) and HCO3 - were measured. Based on the PaCO2 and ETCO2 values, Pa-ETCO2 was determined. There was no significant difference in PaCO2 between the VA (42.5±5.2 to 53.7±5.2) and VP (48.4±5.4 to55.4±5.7) groups. During the postoperative period, all groups presented with hypertension. However, mild hypertension (SAP 150 to 159mmHg) was observed in the VP group as compared to severe hypertension (SAP>180mmHg) in the CA group, suggesting that both the age range and videolaparoscopic OH are associated with lower levels of hypertension during the postoperative period in dogs.

RESUMO: O objetivo deste estudo foi determinar a pressão parcial de dióxido de carbono (PaCO2), pressão ao final da expiração de CO2 (ETCO2) e diferença artério-alveolar de CO2 (Pa-ETCO2) em cadelas pré-púberes e adultas submetidas à ovário-histerectomia (OH) videolaparoscópica ou convencional. Foram distribuídas 40 cadelas em quatro grupos: Convencional Adulto (CA), Convencional Pediátrico (CP), Videolaparoscópico Adulto (VA) e Videolaparoscópico Pediátrico (VP). Foram mensurados frequência de pulso (FP), frequência respiratória (FR), pressões arteriais sistólica (PAS), média (PAM) e diastólica (PAD), ETCO2, pressão de pico inspiratória (PIP), pH, pressão parcial arterial de oxigênio (PaO2), PaCO2, excesso de bases (EB) e HCO3 -. Com base nos valores de PaCO2 e ETCO2 encontrados, foi determinada a Pa-ETCO2. Não foram encontradas diferenças significativas nos valores de PaCO2 entre os grupos VA (42.5±5.2-53,7±5,2) e VP (48.4±5.4 - 55,4±5,7). Todos os grupos apresentaram hipertensão arterial no período pós-operatório. Entretanto, o grupo VP apresentou hipertensão moderada (PAS 150-159mmHg) em comparação ao grupo CA, que apresentou hipertensão severa (PAS>180 mmHg), sugerindo que tanto a faixa etária, quanto a execução de OH por videolaparoscopia, estão associadas a menores taxas de hipertensão pós-operatória em cadelas.

Impact on Quality of Life in Dermatology Patients Attending an Emergency Department / Calidad de vida en pacientes dermatológicos valorados en urgencias

INTRODUCTION: Dermatological complaints have been estimated to represent up to 5-10% of all the visits to emergency departments. The main objective of our study was to determine how affected is the Health related Quality of Life (HRQL) in a series of patients attending an emergency department due to skin symptoms. PATIENTS AND METHODS: A prospective study during one month (July 2016) was conducted in a hospital with full-time on-call dermatologists. The Short-Form SF-12v2 Health Survey and the Dermatology Life Quality Index (DLQI) were offered to all the patients over 18 years old attending the emergency department with cutaneous complaints. Clinical and epidemiological characteristics were also collected. RESULTS: In total 108 patients completed the study. Mean age found was 45.1 ± 16.1 years. Mean DLQI score found was 10.56 ± 6.12. Fifty-three patients (49%) had a score of 11 or higher in the DLQI questionnaire. Most affected subscales were "Symptoms and Feelings" in DLQI scale and "Overall Health" and "Vitality" for the SF-12. A very significant difference (p < 0.0001) was found between women's (12.4 ± 5.7) and men's (7.5 ± 5.6) DLQI mean score (mean difference of 4.9; 95% confidence interval of the difference: 2.7-7.1). CONCLUSIONS: Patients visiting emergency units with cutaneous complaints seem to feel a moderate-large impact on their quality of life which is mainly related to the symptoms and feelings that they are experiencing. This impact is significantly higher among women

INTRODUCCIÓN: Los problemas dermatólogicos suponen hasta un 5-10% de todas las visitas a los servicios de urgencias. El principal objetivo de nuestro estudio fue determinar la calidad de vida relacionada con la salud en una serie amplia de pacientes que acudieron a un servicio de urgencias por sintomatología cutánea. PACIENTES Y MÉTODOS: Se realizó un estudio prospectivo de un mes de duración (julio de 2016) en un hospital terciario con dermatólogo de guardia a tiempo completo. La versión corta del Cuestionario de Salud SF-12v2 y del cuestionario DLQI fueron entregados a todos los pacientes mayores de edad que acudieron al servicio de urgencias con problemas dermatológicos. Se recogió información clínica y epidemiológica de todos los pacientes. RESULTADOS: En total, 108 pacientes completaron el estudio. La edad media de nuestra muestra fue de 45,1±16,1 años. La puntuación media del DLQI fue 10,56±6,12. Del total, 33 pacientes (49%) tuvieron una puntuación de 11 o más en el DLQI. Las subescalas más afectadas fueron la de «síntomas y sentimientos» para el DLQI y las de «salud general» y «vitalidad» para el SF-12. Se encontró una diferencia muy significativa (p < 0,0001) entre las puntuaciones totales del DLQI en mujeres (12,4±5,7) y hombres (7,5±5,6), con una diferencia media de 4,9 (intervalo de confianza al 95%: 2,7-7,1). CONCLUSIONES: Los pacientes que acuden a los servicios de urgencias con problemas dermatológicos parecen tener una afectación moderada-grave en su calidad de vida, debido principalmente a los síntomas que están experimentando. Este impacto es significativamente mayor en las mujeres

Sorafenib-induced Acute Generalized Exanthematous Pustulosis: An Increasing Association? / Pustulosis exantemática generalizada aguda por sorafenib: ¿una relación en aumento?

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Relocation of Croton sonderianus (Euphorbiaceae) seeds by Pheidole fallax Mayr (Formicidae): a case of post-dispersal seed protection by ants?

Although seed dispersal by ants might reduce seed predation near the parent plants, predation on discarded seeds clustered on nest refuse piles may reduce any initial benefit provided by seed removal. Here we examine the fate of Croton sonderianus seeds that were discarded by Pheidole fallax Mayr ants on their nest refuses in caatinga vegetation of northeast Brazil. We collected all seeds discarded in refuse piles of 20 nests and within a radius of 50 cm from their borders, and examined them for evidence of predation. A total of 3,017 seeds were recorded either located in the P. fallax refuse piles (89.1 percent) or nest vicinity (10.9 percent). Predation was three fold higher in nest vicinity as compared to refuse piles. By removing seeds from beneath parent plants and relocating then to refuse piles, P. fallax is possibly providing double protection services for C. sonderianus seeds. Our findings represent the first evidence for predator-avoidance as benefit for plants resulting from ant seed-dispersal in the neotropics.

Colesteatoma de conducto auditivo externo secundario a cirugía previa / External auditory canal cholesteatoma as a complication of ear surgery

Los colesteatomas del conducto auditivo externo (CAE) son una patología infrecuente. Su presentación clínica habitual suele ser en forma de masa que erosiona el CAE, normalmente en sus porciones inferior o anterior, con una membrana timpánica generalmente conservada y un oído medio intacto. Presentamos un caso de esta enfermedad con una revisión de la literatura con el fin de establecer unas pautas actualizadas en la prevención, diagnóstico y manejo de esta rara entidad

External auditory canal cholesteatomas are a rare disease. Their usual clinical appearance is a mass eroding the bony external auditory canal, normally in the inferior or anterior parts, with an intact tympanic membrane and a normal middle ear. A case of this uncommon disease with a review of the scientific literature is presented. Guidelines for the prevention, diagnosis and management are examined

Pollen mother cells of Tradescantia clone 4430 and Tradescantia pallida var. purpurea are equally sensitive to the clastogenic effects of X-rays

The Tradescantia micronucleus test is a sensitive bioassay for mutagenesis that may be employed both under field and laboratory conditions. This test has been standardized mostly on the basis of the results obtained with clone 4430. However, this clone is not well adapted to tropical weather, frequently showing problems with growth and flowering. In addition, it is attacked by parasites and insects, a fact that limits its use in field studies aiming at the biomonitoring of air pollution. In the city of Säo Paulo, Tradescantia pallida (Rose) Hunt. var. purpurea Boom is widely distributed as an ornamental plant in gardens and along roadsides and streets, mostly because of its natural resistance and its easy propagation. In this report, we present dose-response curves indicating that the sensitivity of T. pallida and clone 4430 to X-radiation (1, 10, 25 and 50 cGy) is similar. The results confirm our previous suggestion that T. pallida represents a good alternative for in situ mutagenesis testing in tropical regions, especially biomonitoring studies in which the exposure conditions may not be fully controllable