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1.
Children (Basel) ; 9(1)2022 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-35053712

RESUMO

Due to resource restrictions related to the COVID-19 pandemic, many pediatric patients are facing substantial delays for surgery, potentially resulting in additional distress for caregivers. We aimed to assess the experiences and psychosocial distress of parents during COVID-19 as they relate to the pandemic, waiting for surgery, and the combined effects of both events. The was a cross-sectional qualitative study. Parents with children who faced treatment delays during the initial wave of the COVID-19 pandemic for elective, non-emergent procedures across a variety of surgical specialties were recruited. Semi-structured telephone interviews and thematic analysis were utilized. Thematic saturation was reached with eighteen participants. Four themes were identified: coping with COVID-19, distress levels, quality and nature of communication with the surgical team, and the experience of COVID-19 related hospital restrictions. Participants reported varying levels of distress due to the delay in surgery, such as the fear of developmental delay or disease progression for their child. They also indicated their own physical and mental health had been impacted by emotional distress related to both COVID-19 and delays in treatment. Most participants experienced the COVID-19-related hospital restrictions as distressing. This related predominantly to limiting in-hospital caregivers to only one caregiver. Participants were found to have substantial levels of psychosocial distress. Targeted social and emotional support may be helpful in reducing parental distress as the pandemic timeframe continues. Within the limits of individual health systems, reducing restrictions to the number of allowed care givers may help allay distress felt by parents.

2.
Rev Bras Ortop (Sao Paulo) ; 56(4): 517-522, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34602675

RESUMO

Preoperative planning (PP) is critical to ensure a successful outcome in orthopaedic trauma surgery. Since it was first described thirty years ago, no modifications have been made to the original preoperative planning (OPP) technique, which was written by hand using pen and paper. We believe that the use of presentation software (such as Microsoft PowerPoint, Microsoft Corp., Redmond, WA, US) can ease, improve and update the OPP and complement three-dimensional PP. The objective of the present paper is to describe our method for PP using a presentation software (PS).

3.
World J Orthop ; 12(7): 495-504, 2021 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-34354937

RESUMO

BACKGROUND: Severe open tibia fractures are challenging to treat with a lack of published clear management strategies. Our aim was to provide an overview of the largest single-center experience in the literature, with minimum 1-year follow-up, of adult type 3 open tibial shaft fractures at Cambridge University Hospitals (a United Kingdom major trauma center). We sought to define patient characteristics and our main outcome measures were infection, union and re-fracture. AIM: To retrospectively define patient and injury characteristics, present our surgical methods and analyze our outcomes-namely infection, union and re-fracture rates. METHODS: Consecutive series of 74 patients with 75 open tibial fractures treated between 2014 and 2020 (26 classified as Gustilo-Anderson 3A, 47 were 3B and two were 3C). Nine patients underwent intramedullary nailing (IMN), 61 underwent Taylor spatial frame (TSF) fixation and 5 were treated with Masquelet technique (IMN and subsequent bone grafting). RESULTS: Mean follow-up was 16 mo (IMN) and 25 mo (TSF). We had an infection rate of 6.7% (5), non-union rate of 4% (3) and re-fracture rate of 2.7% (2). Average time to union was 22 wk for IMN and 38.6 wk for TSF. Thirty-three cases had a bone defect with a mean of 5.4 cm (2-11). Patient age, sex, diabetes, smoking status or injury severity did not have a significant effect on union time with either fixation method. Our limb salvage rate was 98.7%. CONCLUSION: Grade 1 to 3A injuries can effectively be treated with reamed or unreamed IMN. Grade 3B/C injuries are best treated by circular external fixators as they provide good, reproducible outcomes and allow large bone defects to be addressed via distraction osteogenesis.

4.
Rev. bras. ortop ; 56(4): 517-522, July-Aug. 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1341180

RESUMO

Abstract Preoperative planning (PP) is critical to ensure a successful outcome in orthopaedic trauma surgery. Since it was first described thirty years ago, no modifications have been made to the original preoperative planning (OPP) technique, which was written by hand using pen and paper. We believe that the use of presentation software (such as Microsoft PowerPoint, Microsoft Corp., Redmond, WA, US) can ease, improve and update the OPP and complement three-dimensional PP. The objective of the present paper is to describe our method for PP using a presentation software (PS).


Resumo O planejamento pré-operatório (PP) é fundamental para garantir um resultado bemsucedido na cirurgia de trauma ortopédico. Desde que foi descrita pela primeira vez há trinta anos, não foram feitas modificações na técnica de planejamento pré-operatório original (PPO), que foi escrita à mão usando caneta e papel. Acreditamos que o uso de um software de apresentação (como o Microsoft PowerPoint, Microsoft Corp., Redmond, WA, EUA) pode facilitar, melhorar e atualizar o PPO e complementar o PP tridimensional. O objetivo deste artigo é apresentar nosso método de PP por meio de software de apresentação (SA).


Assuntos
Humanos , Osso e Ossos/cirurgia , Cuidados Pré-Operatórios , Procedimentos Ortopédicos
5.
J Foot Ankle Surg ; 60(5): 891-896, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33785240

RESUMO

Numerous techniques have been described for first metatarsophalangeal joint (MTPJ) fusion. The aim of this study was to prospectively evaluate an innovative plating system which uses a cross plate compression screw. Thirty consecutive first MTPJ fusions in 28 patients were evaluated. All procedures were performed by a single fellowship trained consultant foot and ankle surgeon. Patient function was evaluated preoperatively at 6 and at 12 months using the Manchester-Oxford Foot Questionnaire (MOXFQ). Union rates and complications were recorded. Postoperative MOXFQ scores demonstrated significant improvement in all domains, with mean improvement at 12 months of 35, 27, 17 and 106 points for pain, walking/standing, social interactions and combined scores respectively (p value ≤.0001). In all 30 cases, clinical and radiological evidence of union was achieved by 6 months. Superficial infection occurred in 1 (3%) case. One (3%) case required plate removal due to soft tissue irritation. There were no plate failures. This evaluation study demonstrates that this cross-plate compression plating system is safe, provides high patient satisfaction and reliable union, with low complication rates. Prospective comparative research is now required to determine the optimal technique for first MTPJ fusion.


Assuntos
Hallux Rigidus , Articulação Metatarsofalângica , Artrodese , Placas Ósseas , Parafusos Ósseos , Hallux Rigidus/diagnóstico por imagem , Hallux Rigidus/cirurgia , Humanos , Articulação Metatarsofalângica/diagnóstico por imagem , Articulação Metatarsofalângica/cirurgia , Estudos Retrospectivos , Resultado do Tratamento
6.
Injury ; 52(4): 1028-1037, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33583592

RESUMO

INTRODUCTION: The treatment of complex pilon fractures and talus fracture-dislocations present several challenges, like avoiding infection, achieving union, management of bone loss and function preservation. METHODS: Retrospective cohort review of fourteen patients who underwent ankle arthrodesis (AA) using the Taylor Spatial Frame (TSF) after pilon and talus fracture-dislocations. Ten tibiocalcaneal (TC) and four tibiotalar (TT) fusions were performed. Eleven of these cases were Gustilo III open fractures. Seven cases involved an open extruded talus. Four cases had established infections. There was a mean of 2.7 (range 0 - 8) operations prior to AA using TSF. The primary objective was to determine infection and union rates. Patient-reported outcomes (Short Form 36, SF-36) and functional outcomes (Ankle Osteoarthritis Score, AOS) were the secondary measures. RESULTS: Eradication and prevention of deep infection was achieved in all cases. Radiological union was achieved at a mean of 9 months (range 5 - 17). Solid AA was achieved in 12 of 14 cases using the TSF. Two TC fusions required a hindfoot fusion nail to achieve union. Eleven cases had concurrent bone transport, mean of 63 mm (range 33 - 180). Mean time of TSF treatment was 11.1 months (range 6 - 16). One case required delayed amputation. Eight patients were able to fully weight bear unaided after the treatment. Mean SF-36 was 65 (range 35 -100). Mean AOS was 36.5 (range 6.6 - 77.5) with 69.3% of scores graded good to excellent. Mean total number of operations was 5.9 (range 2 - 10). Minimum follow up time was 12 months (range 12 - 56). CONCLUSION: AA using TSF can be considered for complex pilon fractures and extruded talus. It has shown to be effective in achieving a solid fusion and infection eradication. While using the TSF in isolation, non-union must be suspected in TC fusions, absence of radiological signs of healing, massive bone loss, and possibly not using bone graft. Patients must be aware that while treatment of these injuries will be prolonged and carries the risk of many potential complications, it provides a good alternative to amputation.


Assuntos
Fraturas do Tornozelo , Traumatismos do Tornozelo , Tálus , Tornozelo , Fraturas do Tornozelo/diagnóstico por imagem , Fraturas do Tornozelo/cirurgia , Artrodese , Humanos , Estudos Retrospectivos , Tálus/diagnóstico por imagem , Tálus/cirurgia , Resultado do Tratamento
7.
J Pediatr Orthop ; 41(4): e309-e315, 2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-33560709

RESUMO

BACKGROUND: Treatment of stable slipped capital femoral epiphysis (SCFE) most commonly involves in situ fixation with a standard cannulated screw, leading to physeal arrest. Recently, Pega Medical (Laval, Canada) introduced the free-gliding (FG) SCFE screw, which employs a growth-friendly, telescopic design. This study examines femoral neck growth and remodeling over the first 2 postoperative years in stable SCFE treated with FG versus standard screws. METHODS: We retrospectively reviewed 32 hips (19 SCFE, 13 prophylactic) in 16 patients treated with FG screws for stable SCFE. We also reviewed 102 hips (63 SCFE, 19 prophylactic, 20 controls) in 55 patients treated with standard screws. Immediate postoperative radiographs were compared with 1- and 2-year follow-up images. RESULTS: For the overall study cohort, mean age at surgery was 12.2±1.9 years, with a mean slip angle of 26.9±18.0 degrees. In FG SCFE hips, the alpha angle remodeled 12.9±19.2 degrees in the first postoperative year (P=0.018) and articulotrochanteric distance decreased by 4.2±4.6 mm at 2 years (P=0.018). In standard SCFE hips, the alpha angle remodeled 4.3±11.3 degrees at 1 year (P=0.014), while articulotrochanteric distance decreased by 4.5±3.2 mm at 2 years (P<0.001). By 2 years, FG screws lengthened more in prophylactic (4.8±3.4 mm) than SCFE hips (1.7±1.8 mm, P=0.027). CONCLUSIONS: Greater remodeling of femoral neck cam deformity occurs when treating SCFE using an FG screw. Further research is required to measure the impact of this finding on femoroacetabular impingement and degenerative arthritis. In addition, FG screws allow ongoing growth of prophylactically treated hips, while standard screws promote coxa breva. LEVEL OF EVIDENCE: Level III-retrospective comparative, therapeutic study.


Assuntos
Remodelação Óssea , Parafusos Ósseos , Colo do Fêmur/crescimento & desenvolvimento , Escorregamento das Epífises Proximais do Fêmur/cirurgia , Adolescente , Criança , Epífises/cirurgia , Feminino , Humanos , Masculino , Período Pós-Operatório , Radiografia , Estudos Retrospectivos
8.
Foot Ankle Orthop ; 5(2): 2473011420923591, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35097380

RESUMO

BACKGROUND: The Ponseti method has revolutionized the treatment of idiopathic clubfoot, but recurrence remains problematic. Dynamic supination is a common cause of recurrence, and the standard treatment is tibialis anterior tendon transfer using an external button. Although safe and effective, the placement of the button on the sole creates a pressure point, which can lead to skin ulceration. In our institution, a suture button has been used for the tibialis anterior tendon transfer and we report our results here. METHODS: Two senior authors' case logs were retrospectively reviewed to identify 23 patients (34 feet) for tibialis anterior tendon transfer using a suture button. Complications and additional operative procedures were assessed by reviewing operative notes, follow-up visit clinic notes, and radiographs. The mean age of the patients was 6 years 2 months (SD 40 months) and the average follow-up duration was 67.1 weeks (SD 72 weeks). RESULTS: There were 5 complications (14.7%). Recurrence occurred bilaterally in 1 patient (5.9%) but did not require reoperation. Other complications included a cast-related pressure sore (2.9%) and an infection (2.9%) requiring irrigation with debridement along with hardware removal. CONCLUSIONS: Tibialis anterior tendon transfer using a suture button was a safe procedure with theoretical advantage of providing stronger fixation and reducing the risk of skin pressure necrosis compared to the standard external button technique. We believe a suture button could allow earlier rehabilitation and may afford stronger ankle eversion. Prospective studies are required to compare the differences in functional outcomes between the procedures. LEVEL OF EVIDENCE: Level IV, case series, therapeutic study.

9.
JBJS Case Connect ; 9(4): e0511, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31651441

RESUMO

CASE: We describe the case of a dysplasia epiphysealis hemimelica (DEH) lesion affecting uniquely the lunate bone in a 16-year-old boy causing pain, stiffness, and decreased range of motion. Surgical excision was performed, leading to resolution of primary symptoms with residual limitations in terminal wrist extension. CONCLUSIONS: From our review of the literature, we believe this case to be the first report of a DEH lesion affecting solely the lunate bone. Although conservative and surgical management have both been described with DEH cases, we report a positive outcome following the excision of a symptomatic lesion.


Assuntos
Doenças do Desenvolvimento Ósseo/diagnóstico por imagem , Fêmur/anormalidades , Osso Semilunar/diagnóstico por imagem , Tíbia/anormalidades , Adolescente , Doenças do Desenvolvimento Ósseo/patologia , Doenças do Desenvolvimento Ósseo/cirurgia , Fêmur/diagnóstico por imagem , Fêmur/patologia , Fêmur/cirurgia , Humanos , Osso Semilunar/patologia , Masculino , Tíbia/diagnóstico por imagem , Tíbia/patologia , Tíbia/cirurgia , Tomografia Computadorizada por Raios X
10.
J Orthop Surg Res ; 14(1): 187, 2019 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-31227002

RESUMO

BACKGROUND: Cerebral palsy (CP) is the most common cause of childhood disability, typified by a static encephalopathy with peripheral musculoskeletal manifestations-most commonly related to spasticity-that are progressive with age. Hip displacement is one of the most common manifestations, observed to lead to painful degenerative arthritis over time. Despite the key role that spasticity-related adductor muscle contractures are thought to play in the development of hip displacement in CP, basic science research in this area to date has been limited. This study was initiated to correlate hip adductor muscle changes intrinsic to the sarcomere-specifically, titin isoforms and sarcomere length-to the severity of hip displacement in children with spastic cerebral palsy. METHODS: Single gracilis muscle biopsies were obtained from children with CP (Gross Motor Function Classification System (GMFCS) III-V; n = 10) who underwent adductor muscle release surgery for the treatment of hip displacement. Gel electrophoresis was used to estimate titin molecular weight. Sarcomere lengths were measured from muscle fascicles using laser diffraction. The severity of hip displacement was determined by measuring by Reimers migration percentage (MP) from anteroposterior pelvic x-rays. Correlation analyses between titin, sarcomere lengths, and MP were performed. RESULTS: The mean molecular weight of titin was 3588 kDa. The mean sarcomere length was 3.51 µm. Increased MP was found to be associated with heavier isoforms of titin (R2 = 0.65, p < 0.05) and with increased sarcomere lengths (R2 = 0.65, p < 0.05). Heavier isoforms of titin were also associated with increased sarcomere lengths (R2 = 0.80, p < 0.05). CONCLUSIONS: Our results suggest that both larger titin isoforms and sarcomere lengths are positively correlated with increased severity of hip displacement and may represent adaptations in response to concomitant increases in spasticity and muscle shortening. TRIAL REGISTRATION: As this study does not report the results of a health care intervention on human participants, it has not been registered.


Assuntos
Paralisia Cerebral/patologia , Luxação do Quadril/etiologia , Músculo Esquelético/patologia , Sarcômeros/patologia , Biópsia , Paralisia Cerebral/complicações , Criança , Pré-Escolar , Feminino , Músculo Grácil/patologia , Luxação do Quadril/patologia , Humanos , Projetos Piloto
11.
J Biomech ; 87: 100-106, 2019 04 18.
Artigo em Inglês | MEDLINE | ID: mdl-30853092

RESUMO

Cerebral palsy (CP) is the result of a static brain lesion which causes spasticity and muscle contracture. The source of the increased passive stiffness in patients is not understood and while whole muscle down to single muscle fibres have been investigated, the smallest functional unit of muscle (the sarcomere) has not been. Muscle biopsies (adductor longus and gracilis) from pediatric patients were obtained (CP n = 9 and control n = 2) and analyzed for mechanical stiffness, in-vivo sarcomere length and titin isoforms. Adductor longus muscle was the focus of this study and the results for sarcomere length showed a significant increase in length for CP (3.6 µm) compared to controls (2.6 µm). Passive stress at the same sarcomere length for CP compared to control was significantly lower in CP and the elastic modulus for the physiological range of muscle was lower in CP compared to control (98.2 kPa and 166.1 kPa, respectively). Our results show that CP muscle at its most reduced level (the myofibril) is more compliant compared to normal, which is completely opposite to what is observed at higher structural levels (single fibres, muscle fibre bundles and whole muscle). It is noteworthy that at the in vivo sarcomere length in CP, the passive forces are greater than normal, purely as a functional of these more compliant sarcomeres operating at long lengths. Titin isoforms were not different between CP and non-CP adductor longus but titin:nebulin was reduced in CP muscle, which may be due to titin loss or an over-expression of nebulin in CP muscles.


Assuntos
Paralisia Cerebral/fisiopatologia , Músculo Esquelético/patologia , Miofibrilas/patologia , Fenômenos Biofísicos , Biópsia , Criança , Pré-Escolar , Conectina/química , Conectina/metabolismo , Humanos , Espasticidade Muscular/patologia , Sarcômeros/fisiologia
12.
J Hip Preserv Surg ; 6(4): 304-315, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32015887

RESUMO

The purpose of this study was to evaluate the current available literature on hip arthroscopy and determine the clinical indications in the pediatric patient population (age ≤ 18). In accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), a comprehensive literature search was performed on the 23 October 2018 using PubMed, Cochrane Library, Embase and e-books to identify research surrounding the use of hip arthroscopy in the pediatrics. Exclusion criteria were studies that described joints other than the hip, animal studies, systematic reviews, open procedures and those that reported solely on patients aged 19-year-old and older. From 232 studies, 57 were reviewed in detail; 17 articles were removed as their indication fell into a category of 'diagnostic hip arthroscopy for pain' or no clear separation between the data on the adult and pediatric population could be made in a full text review of the paper. Eleven categories were identified as indications for hip arthroscopy in the pediatric population. At best a Grade C recommendation can be made to support the use of hip arthroscopy in the pediatric population. Our results support our hypothesis. Despite the exponential increase in hip arthroscopy over the last decade, limited evidence exists in support of its use in the pediatric (≤18) population. Our findings support the need for further research in delineating the indications for its use, as clearly arthroscopy may be advantageous in many situations, particularly in light of the alternatives.

13.
J Pediatr Orthop B ; 27(6): 496-502, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29762188

RESUMO

Physeal closure after slipped capital femoral epiphysis fixation can be difficult to assess on two-dimensional conventional radiographs. Radiostereometric analysis offers improved motion detection over conventional radiography, whereas the EOS biplanar imager provides a means for low radiation weight-bearing images. This phantom study assessed the reliability of measuring motion using radiostereometric analysis in the EOS using a slipped capital femoral epiphysis model. The accuracy and precision were better than 0.09±0.05 mm and 0.20°±0.36° when centered in the imaging space, were within the limits of clinical significance, and were not different from a standard uniplanar radiostereometric system.


Assuntos
Lâmina de Crescimento/diagnóstico por imagem , Imagens de Fantasmas/normas , Análise Radioestereométrica/normas , Escorregamento das Epífises Proximais do Fêmur/diagnóstico por imagem , Humanos , Análise Radioestereométrica/métodos , Reprodutibilidade dos Testes
14.
J Pediatr Orthop B ; 27(1): 1-7, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28799981

RESUMO

This retrospective cohort study examined 20 patients (48 physes), 11 boys and nine girls, who were treated with hinge-plate or eight-plate. The mean age of the patients at surgery was 11.9±2.6 years. The mean follow-up duration was 13±2.7 months. The radiographic measurement of both distal femoral and proximal tibial deformity showed significant correction, with no difference between the hinge-plate and the eight-plate. Both screw divergence angle and the hinge angle showed significant changes at the last follow-up. The deformity correction of the distal femoral physis was quicker than the proximal tibial physis. The rate of mechanical femoral-tibial angle correction was 0.97°/month if both femoral and tibial physes were treated. LEVEL OF EVIDENCE: III.


Assuntos
Doenças do Desenvolvimento Ósseo/cirurgia , Placas Ósseas , Artropatias/cirurgia , Articulação do Joelho/anormalidades , Articulação do Joelho/cirurgia , Adolescente , Criança , Desenho de Equipamento , Feminino , Fêmur/diagnóstico por imagem , Fêmur/cirurgia , Humanos , Masculino , Estudos Retrospectivos , Tíbia/diagnóstico por imagem , Tíbia/cirurgia
15.
J Pediatr Orthop B ; 25(5): 412-6, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26517762

RESUMO

UNLABELLED: Flexion-type supracondylar fractures are challenging to treat because, unlike extension-type fractures, it is difficult to take advantage of the intact periosteal hinge to stabilize the fracture fragments during percutaneous pinning. Some authors have described closed reduction of these fractures with the elbow in extension, followed by percutaneous K-wire fixation. However, percutaneous pinning with elbow in extension is technically difficult, time consuming, and usually requires the help of a skilled assistant because of persistent fracture instability. To circumvent these difficulties, we utilized a 'push-pull' maneuver, which simplifies the closed reduction and fixation of these difficult fractures. We describe the surgical technique for the 'push-pull' method and report radiographic outcomes of a case series of children with flexion-type supracondylar fractures treated using this technique. A retrospective review of medical records and radiographs of all children who underwent operative treatment of a flexion-type supracondylar humeral fracture using the 'push-pull' method in a tertiary-level children's hospital between January 2009 and January 2014 was carried out. Radiographic outcomes were reported using descriptive statistics. There were a total of nine patients (five females, four males), average age 9.8 years (4-14 years). Seventy-eight percent (7/9 patients) of the children had type III injuries, whereas 22% (two children) had type II injuries. The average duration of surgery was 41 min (24-60 min). No intraoperative or postoperative complications were recorded. Postoperative radiographic measures showed that the anterior humeral line passed through the middle third of capitellum in 78% of patients (7/9 patients), whereas it passed posterior to it in 22% (two patients). The average humerocapitellar angle was 30° (21-44°) and the anterior coronoid line was unbroken in 44% (4/9 patients). The average humeroulnar angle was 13° (8-20°) of valgus. The 'push-pull' is a safe, effective, and easy method to treat unstable flexion-type supracondylar fractures in children with good radiographic postoperative outcomes. LEVEL OF EVIDENCE: level IV.


Assuntos
Fios Ortopédicos , Articulação do Cotovelo/cirurgia , Fixação Interna de Fraturas , Fixação Intramedular de Fraturas , Fraturas do Úmero/cirurgia , Adolescente , Criança , Pré-Escolar , Cotovelo/cirurgia , Feminino , Hospitais Pediátricos , Humanos , Úmero/cirurgia , Masculino , Amplitude de Movimento Articular , Estudos Retrospectivos , Centros de Atenção Terciária , Resultado do Tratamento , Lesões no Cotovelo
16.
J Transplant ; 2012: 134936, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22132302

RESUMO

Uterine transplantation has been proposed as a possible solution to absolute uterine factor infertility untreatable by any other option. Since the first human attempt in 2000, various teams have tried to clarify which immunosuppressant would be most suitable for protecting the allogeneic uterine graft while posing a minimal risk to the fetus. Cyclosporine A (CsA) is an immunosuppressant widely used by transplant recipients. It is currently being tested as a potential immunosuppressant to be used during UTn. Its effect on the mother and fetus and its influence upon the graft during pregnancy have been of major concern. We review the role of CsA in UTn and its effect on pregnant transplant recipients and their offspring.

17.
Foot Ankle Int ; 27(6): 414-7, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16764797

RESUMO

BACKGROUND: Tendon lengthening is an important cause of morbidity after Achilles tendon rupture. However, direct measurement of the tendon length is difficult. Ankle dorsiflexion has, therefore, been used as a surrogate measure on the assumption that it is the Achilles tendon that limits this movement. The aim of this investigation was to assess the relationship between Achilles tendon length and ankle dorsiflexion. The primary question was whether or not the Achilles tendon is the structure that limits ankle dorsiflexion. The secondary purpose was to quantify the relationship between Achilles tendon lengthening and dorsiflexion at the ankle joint. METHODS: Five cadaver specimens were dissected to expose the tendons and capsular tissue of the leg and hindfoot. Fixed bony reference points were used as markers for the measurements. In the first specimen, the Achilles tendon was intact and the other structures that may limit ankle dorsiflexion were sequentially divided. In the other specimens the Achilles tendon was lengthened by 1 cm intervals and the effect upon ankle dorsiflexion movement was recorded. RESULTS: Division of the other tendons and the capsular tissue around the ankle joint did not affect the range of ankle dorsiflexion. When the Achilles was divided the foot could be dorsiflexed until the talar neck impinged upon the anterior aspect of the distal tibia. There was a mean increase of 12 degrees of dorsiflexion for each centimeter increase in tendon length. CONCLUSION: The Achilles tendon is the anatomical structure that limits ankle dorsiflexion, even when the tendon is lengthened. There was a linear relationship between the length of the Achilles tendon and the range of ankle dorsiflexion in this cadaver model. Ankle dorsiflexion would appear to be a clinically useful indicator of tendon length.


Assuntos
Tendão do Calcâneo/anatomia & histologia , Tendão do Calcâneo/cirurgia , Articulação do Tornozelo/fisiologia , Amplitude de Movimento Articular/fisiologia , Articulação do Tornozelo/anatomia & histologia , Fenômenos Biomecânicos , Cadáver , Dissecação , Humanos , Procedimentos Ortopédicos , Tendões/anatomia & histologia , Tendões/fisiologia
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