[Effect of cryopreserved cord blood nucleated cells on course of pathological processes in progressive aging of brain (experimental study).]

The data on morphometric indices of the vascular bed and brain substance of spontaneously hypertensive SHR rats, which can be considered as an evidence of the developing pathological brain aging processes in these animals, are presented in the work. Chronic alcohol intoxication aggravates the neurodegeneration, significantly reducing the indices of the neuroglial index, the number of functioning vessels and activating the LPO processes. Single intraperitoneal administration of cryopreserved human cord blood nucleated cells in a dose of (1-5)‧107/kg promoted the regeneration of neurocells, stimulation of angiogenesis and an increased level and quality of neurotissue metabolism, reducing the signs of dystrophic, destructive and pathologically altered compensatory adaptive processes in the rat's brain as a result of the restoration of its microhemocirculation and cytoarchitecture.

[Use of cranio-cerebral hypothermia among the complex resuscitation measures in mental disorders]. / Primenenie kraniotserebral'noi gipotermii v komplekse reanimatsionnykh meropriiatii pri psikhicheskikh zabolevaniiakh.

Craniocerebral hypothermia was employed in multimodality treatment of 10 patients with hypertoxic schizophrenia and 60 patients with intoxication psychoses, the clinical picture of which was characterized by increasing hypoxia and edema-swelling of the brain. Hypothermia was made to a cerebral temperature of 28-30 degrees C for 4-6 hours in the presence of the neurovegetative blockade. The data obtained attest to a high therapeutic efficacy of craniocerebral hypothermia.