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1.
Clin Nephrol ; 67(4): 209-16, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17474556

RESUMO

AIMS: Left ventricular hypertrophy (LVH) is a predictor for cardiovascular mortality, and it is considered to be a surrogate marker of preclinical cardiovascular disease. This study aimed at evaluating whether fetuin-A plasma levels are decreased in patients with moderate chronic kidney disease (CKD) and their linkage to plasma concentrations of hs-C-reactive protein (CRP), cardiotrophyn-1 (CT-1), tumor necrosis factor-ac (TNF-alpha), propeptide of collagen Type I (PIP) and to LVH. MATERIAL AND METHODS: We enrolled 64 moderate CKD and 55 essential hypertensives (EH) with normal renal function as controls. All the patients underwent an echocardiographic examination; plasma samples were obtained to measure routine clinical parameters and the molecules listed above (measured by ELISA). RESULTS: Among CKD there were 30/64 patients with LVH, and in EH group 14/55 subjects had LVH. Fetuin A was reduced in CKD when compared with EH (p < 0.0001). The comparison between CKD having LVH with those without LVH showed significant differences in plasma levels of fetuin-A (p < 0.002), TNF-alpha (p < 0.01) and hs-CRP (p < 0.001), CT-1 and PIP (p < 0.002). CKD with LVH had lower values of fetuin-A (p < 0.001), and higher values of hs-CRP (p < 0.001) TNF-alpha (p < 0.001), CT-1 (p < 0.001) and PIP (p < 0.001) than EH with LVH. The multivariate analysis of correlation demonstrated that in CKD patients hs-CRP (beta 0.42, p < 0.00006), and systolic blood pressure (beta 0.29, p < 0.02) were independent predictors of LV mass index. The relationship between LV mass index and fetuin-A did not reach statistical significance. CONCLUSIONS: For the first time in moderate CKD patients, we demonstrate that fetuin-A is decreased and relates to LVH depending on C-reactive protein.


Assuntos
Hipertrofia Ventricular Esquerda/sangue , Falência Renal Crônica/sangue , Adulto , Análise de Variância , Biomarcadores/sangue , Proteína C-Reativa/metabolismo , Estudos de Casos e Controles , Citocinas/sangue , Ecocardiografia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Hipertrofia Ventricular Esquerda/diagnóstico por imagem , Inflamação/sangue , Masculino , Pessoa de Meia-Idade , Fosfopeptídeos/sangue , Pró-Colágeno/sangue , Análise de Regressão , Fator de Necrose Tumoral alfa/sangue , alfa-Fetoproteínas/metabolismo
2.
J Hum Hypertens ; 21(2): 167-72, 2007 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17051235

RESUMO

We hypothesized that in essential hypertensive patients (EHs), plasma levels of pro-atherogenic adhesion molecules would be increased and related with urine albumin excretion (UAE). Thus, this study was aimed at evaluating biochemical markers of endothelial activation and their relationship with UAE in a group of patients with uncomplicated EH. In basal condition soluble forms of adhesion molecules intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1, as well as 24-h UAE were assayed. One hundred patients with essential hypertension and no diabetes or ultrasonographic evidence of atherosclerosis were included in the study. Seventy normotensive healthy subjects served as controls. EHs were first studied overall, than were divided into two subgroups: those with UAE > or =20 mcg/min MAUs and those with UAE <20 mcg/min (non-MAUs). ICAM-1 (P<0.001) and VCAM-1 (P<0.0001) plasma concentrations were higher in EHs than in controls. Microalbuminuric EHs had greater levels of adhesion molecules than non-MAUs (ICAM-1 P=0.04; VCAM-1 P=0.02, respectively). In EHs UAE was correlated with ICAM-1 (r=0.29, P=0.003), and VCAM-1 (r=0.30, P=0.002). These associations were confirmed in multiple regression models (P=0.02 for both ICAM-1 and VCAM-1) including, along with adhesion molecules, age, body mass index and blood pressures. Our findings show that in essential hypertension there is a very early activation of endothelial adhesion molecules favouring atherosclerosis.


Assuntos
Albuminúria/etiologia , Endotélio Vascular/fisiopatologia , Hipertensão/fisiopatologia , Adulto , Aterosclerose/etiologia , Proteína C-Reativa/análise , Feminino , Humanos , Hipertensão/complicações , Hipertensão/urina , Molécula 1 de Adesão Intercelular/sangue , Masculino , Pessoa de Meia-Idade , Análise de Regressão , Molécula 1 de Adesão de Célula Vascular/sangue
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