1.
Hepatobiliary Surg Nutr
; 13(1): 119-123, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38322226
2.
Neuroscience
; 514: 123-140, 2023 03 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36736614
RESUMO
Alzheimer's disease (AD) and other neurodegenerative diseases, for which there is no effective cure, cause great social burden. Apolipoprotein E (APOE) is an important lipid transporter, which has been shown to have a close relationship with AD and other neurological disorders in an increasing number of studies, suggesting its potential as a therapeutic target. In this review, we summarize the recent advances in clinical and basic research on the role of APOE in the pathogenesis of multiple neurological diseases, with an emphasis on the new associations between APOE and AD, and between APOE and depression. The progress of APOE research in Parkinson's disease (PD) and some other neurological diseases is briefly discussed.