A bromine analogue of picoplatin: a new substance from the group of platinum-based chemotherapeutics.

A new substance, cis-amminedibromido(2-methylpyridine-κN)platinum(II), cis-[PtBr2(C6H7N)(NH3)], which is a potential platinum-based antineoplastic agent for the treatment of patients with solid tumors, has been synthesized and structurally characterized. There is one molecule in the asymmetric unit and molecules are linked via two symmetry-independent N-H···Br hydrogen bonds into zigzag chains running parallel to the c axis. C-H···Br hydrogen bonds crosslink these chains to give a layer parallel to (010). N-H···Br hydrogen bonds and π-π stacking interactions between pairs of pyridine rings stack the layers along b.

25,26,27,28-Tetra-propoxycalix[4]arene-5,17-dicarbonitrile.

In the title compound, C(42)H(46)N(2)O(4), both crystallographically independent mol-ecules display a 1,3-alternate conformation. Their crystal packing is stabilized by non-classical C-H⋯N hydrogen bonds. The dihedral angles between the planes of the aromatic rings and the mean plane through the methyl-ene C atoms bridging the aromatic rings are 78.10 (13), 80.74 (14), 81.89 (12) and 79.05 (14)° for the first mol-ecule, and 71.65 (11), 76.60 (13), 77.97 (14) and 74.76 (13)° for the second mol-ecule. Both mol-ecules have three C atoms of one prop-oxy chain disordered over two set of sites; the site-occupancy factors are 0.7/0.3 and 0.6/0.4, respectively.