1.
Messenger (Los Angel)
; 5(1-2): 67-75, 2016 Jun 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28529828
RESUMO
Two-pore channels are endolysosomal Ca2+ release channels involved in proper trafficking to and from those organelles. They are the likely targets for the Ca2+-mobilizing messenger NAADP, and are further regulated by a variety of mechanisms including phosphoinositide levels and Rab proteins. As discussed here, recent studies highlight a role for these channels in the pathomechanism(s) underlying Parkinson's disease, with important implications for possible alternative treatment strategies.