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BACKGROUND: Respiratory viruses are increasingly detected in children with community-acquired pneumonia. Further strategies to limit antibiotic use in children with viral pneumonia are warranted. AIM: To explore clinical efficacy of budesonide/formoterol inhalation powder for viral pneumonia in children and its impact on cellular immunity and inflammatory factor production. METHODS: A total of 60 children with viral pneumonia were recruited: 30 receiving budesonide/formoterol inhalation powder and 30 conventional symptomatic treatment. Outcome measures included peripheral blood levels of inflammatory cytokines, CD4+, CD8+, Th1, Th2, Th17 and Treg, clinical efficacy, and incidence of adverse reactions. RESULTS: Compared with the control group, the observation group showed a significant reduction in interleukin-6 and high-sensitivity C-reactive protein levels after treatment. Compared with the control group, the observation group showed a significant increase in CD4+/CD8+ and Th1/Th2 levels, and a decrease in Th17/Treg levels after treatment. The total effective rates in the observation group and the control group were 93.75% and 85.00%, respectively, which was a significant difference (P = 0.003). CONCLUSION: Budesonide/formoterol inhalation powder significantly improved therapeutic efficacy for viral pneumonia in children. The mechanism of action may be related to downregulation of the inflammatory response and improved cellular immune function.
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Mercury ions sensing is an important issue for human health and environmental safety. A novel fluorescence nanosensor was designed for rapid visual detection of ultratrace mercury ions (Hg2+) by using CH3NH3PbBr3 perovskite quantum dots (QDs) based on the surface ion-exchange mechanism. The synthesized CH3NH3PbBr3 QDs can emitt intense green fluorescence with high quantum yield of 50.28%, and can be applied for Hg2+ sensing with the detection limit of 0.124 nM (24.87 ppt) in the range of 0 nM-100 nM. Furthermore, the interfering metal ions have no any influence on the fluorescence intensity of QDs, showing the perovskite QDs possess the high selectivity and sensitivity for Hg2+ detection. The sensing mechanism of perovskite QDs for Hg2+ is has also been investigated by XPS, EDX studies, showing Pb2+ on the surface of perovskite QDs has been partially replaced by Hg2+. Spot plate test shows that the perovskite QDs can also be used for visual detection of Hg2+. Our research indicated the perovskite QDs are promising candidates for the visual fluorescence detection of environmental micropollutants.
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The phosphorescent l-cysteine modified manganese-doped zinc sulfide quantum dots (l-cys-MnZnS QDs) was developed for a highly sensitive detection of permanganate anions (MnO4-). l-cys-MnZnS QDs, which were easily synthesized in aqueous media using safe and low-cost materials, can emit intense phosphorescence even though the solution was not deoxygenated. However, the phosphorescence of l-cys-Mn-ZnS QDs was strongly quenched by MnO4- ascribed to the oxidation of l-cys and the increase of surface defects on l-cys-MnZnS QDs. Under the optimal conditions, l-cys-MnZnS QDs offer high selectivity over other anions for MnO4- determination, and good linear Stern-Volmer equation was obtained for MnO4- in the range of 0.5-100µM with a detection limit down to 0.24µM. The developed method was finally applied to the detection of MnO4- in water samples, and the spike-recoveries fell in the range of 95-106%.
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Here we report a silver nanoparticle based surface enhanced resonance Raman scattering (SERRS) probe for the ultrasensitive and selective detection of formaldehyde. The detection limit reaches as low as 10(-11) M.
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Direct fabrication of core-shell or yolk-shell functional nanomaterials via a facile template-free method remains a challenge. In this work, we present a novel approach that involves straightforward chemical transformation and thermal treatment of the infinite coordination polymer particles to obtain composition-tunable CeO(2) yolk-shell structures. Uniform CeO(2) yolk-shell hollow spheres with a high surface area are promising support materials for tiny gold nanoparticles (ca. 4 nm), forming Au-CeO(2) nanocomposites which exhibit a remarkable catalytic activity and high stability for the reduction of p-nitrophenol. A possible mechanism for the formation of CeO(2) yolk-shell microspheres is also proposed.
Assuntos
Cério/química , Ouro/química , Nanopartículas Metálicas/química , Nitrofenóis/química , Catálise , Nanocompostos/química , Oxirredução , Polímeros/química , Propriedades de SuperfícieRESUMO
N-doped TiO(2) nanoparticles modified with carbon (denoted N-TiO(2)/C) were successfully prepared by a facile one-pot hydrothermal treatment in the presence of L-lysine, which acts as a ligand to control the nanocrystal growth and as a source of nitrogen and carbon. As-prepared nanocomposites were characterized by thermogravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), Raman spectroscopy, ultraviolet-visible (UV-vis) diffuse reflectance spectroscopy, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), electron paramagnetic resonance (EPR) spectra, and N(2) adsorption-desorption analysis. The photocatalytic activities of the as-prepared photocatalysts were measured by the degradation of methyl orange (MO) under visible light irradiation at λ≥ 400 nm. The results show that N-TiO(2)/C nanocomposites increase absorption in the visible light region and exhibit a higher photocatalytic activity than pure TiO(2), commercial P25 and previously reported N-doped TiO(2) photocatalysts. We have demonstrated that the nitrogen was doped into the lattice and the carbon species were modified on the surface of the photocatalysts. N-doping narrows the band gap and C-modification enhances the visible light harvesting and accelerates the separation of the photo-generated electrons and holes. As a consequence, the photocatalytic activity is significantly improved. The molar ratio of L-lysine/TiCl(4) and the pH of the hydrothermal reaction solution are important factors affecting the photocatalytic activity of the N-TiO(2)/C; the optimum molar ratio of L-lysine/TiCl(4) is 8 and the optimum pH is ca. 4, at which the catalyst exhibits the highest reactivity. Our findings demonstrate that the as-obtained N-TiO(2)/C photocatalyst is a better and more promising candidate than well studied N-doped TiO(2) alternatives as visible light photocatalysts for potential applications in environmental purification.