Pyroptosis: A promising biomarker for predicting colorectal cancer prognosis and enhancing immunotherapy efficacy.

In this editorial, we comment on the article by Zhu et al published in the recent issue of the World Journal of Clinical Oncology. We focus specifically on the characteristics and mechanisms of pyroptosis and the impact of changes in the tumor immune microenvironment (TIME) on cancer prognosis. Pyroptosis is a distinct form of programmed cell death; its occurrence can change the TIME and regulate the growth and spread of tumors and therefore is significantly correlated with cancer prognosis. Previous research has demonstrated that pyroptosis-related genes can be used in prognostic models for various types of cancer. These models enhance the mechanistic understanding of tumor evolution and serve as valuable guides for clinical treatment decision-making. Nevertheless, further studies are required to thoroughly understand the function of pyroptosis within the TIME and to assess its mode of action. Such studies should reveal new tumor therapeutic targets and more successful tumor immunotherapy strategies.

Alternations of Blood Pressure Before and After OSA Surgery.

OBJECTIVE: To investigate the changes of blood pressure (BP) on patients with obstructive sleep apnea/hypopnea syndrome (OSA) before and after upper airway surgery. DESIGN: Case series with chart review. SETTING: Tertiary academic medical center. SUBJECTS AND METHODS: Patients with OSA who underwent upper airway surgery were enrolled. We retrospectively investigated the nighttime and daytime BP before and at least 3 months after OSA surgery. Paired t test was used to compare the changes of BP before and after surgery. Generalized estimating equation was used to examine the prognostic significance of the variables in predicting the changes of postoperative BP. RESULTS: In total, 176 patients with OSA (149 men, 27 women; mean age, 42.9 years; mean apnea/hypopnea index, 43.1/h) were enrolled in this study. The overall nighttime and daytime BP decreased significantly before and after OSA surgery (daytime systolic BP was reduced from 137.3 ± 14.0 mm Hg to 132.7 ± 17.0 mm Hg, P < .01; nighttime systolic BP was reduced from 138.7 ± 16.0 mm Hg to 133.7 ± 15.3 mm Hg, P < .01; daytime diastolic BP was reduced from 87.7 ± 14.7 mm Hg to 84.9 ± 10.6 mm Hg, P = .01; nighttime diastolic BP was reduced from 85.4 ± 12.9 mm Hg to 83.1 ± 11.1 mm Hg, P = .02). The changes of nighttime systolic and diastolic BP were significantly associated with the improvement of percentage of O2 saturation <90% during polysomnography. CONCLUSION: Surgical modifications of the upper airways for patients with OSA could benefit blood pressure.

[Heavy metal pollution characteristics and ecological risk analysis for soil around Haining electroplating industrial park].

The pollution status and potential ecological risks of heavy metal in soils around Haining electroplating industrial park were studied. Hakanson index approach was used to assess the ecological hazards of heavy metals in soils. Results showed that average concentrations of six heavy metals (Cu, Ni, Pb, Zn, Cd and Cr) in the soils were lower than the secondary criteria of environmental quality standard for soils, indicating limited harmful effects on the plants and the environment in general. Though the average soil concentrations were low, heavy metal concentrations in six sampling points located at the side of road still exceeded the criteria, with excessive rate of 13%. Statistic analysis showed that concentrations of Cu and Cd in roadside soils were significantly higher than those in non-roadside soils, indicating that the excessive heavy metal accumulations in the soil closely related with traffic transport. The average potential ecological hazard index of soils around Haining electroplating industrial park was 46.6, suggesting a slightly ecological harm. However, the potential ecological hazard index of soils with excessive heavy metals was 220-278, suggesting the medium ecological hazards. Cd was the most seriously ecological hazard factor.