1.
Bioorg Med Chem Lett
; 16(24): 6226-30, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17010607
RESUMO
A series of xanthine mimetics containing 5,5 and 5,6 heterocycle fused imidazoles were synthesized as dipeptidyl peptidase IV inhibitors. Compound 7 is potent (h-DPPIV K(i)=2nM) and exhibits excellent selectivity and no species specificity against rat and human enzymes. The X-ray structure confirms that the binding mode of 7 to rat DPPIV is similar to the parent xanthines.