RESUMO
No disponible
Assuntos
Humanos , Masculino , Recém-Nascido , Doença da Urina de Xarope de Bordo/genética , Convulsões/etiologia , Mutação , Descarboxilação , EletroencefalografiaRESUMO
A prospective study, by epidemiological survey, was carried out in the 447 children with acute poisoning attended in our hospital between February 1, 1990 and January 31, 1991. All data was processed to analyze the possible associations that would help to better understand the factors that take part in poisoning. We observed a predominance in male infants, with a greater incidence between two and three years of age, and the accidents occurred almost exclusively at home, mainly in the kitchen or bedroom. The child is often not adequately watched and the toxic elements are usually within easy access. There was neither a seasonal nor daily predominance. We noticed an hourly predominance with most accidents occurring between 12 a.m. and 4 p.m. Drugs are the most common agents, followed by household cleaning products. Morbidity was scarce and there was no mortality.
Assuntos
Intoxicação/epidemiologia , Acidentes Domésticos , Fatores Etários , Criança , Pré-Escolar , Detergentes/intoxicação , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Feminino , Produtos Domésticos , Humanos , Lactente , Masculino , Preparações Farmacêuticas/administração & dosagem , Fatores SexuaisRESUMO
Authors studied phenobarbital level's in serum in 21 newborns with convulsant syndrome. They consider serum's levels after five minutes and after 12-24 hours, the best time to study maximum action and duration of levels in relation to sedative limits. Non-radio-active immunoanalysis was used as markers instead reactive substances of enzymes. Enzymatic activities are measured by addition of substrates for enzyme employed (in this case G-6-PDH). PB dose employed was between 10 mg/kg IV in nine newborns and 20 mg/kg in another 13. All of them experienced a support dose between 2 and 4 mg/kg/24 hours during a week's time after sedation. Variable affects were: only 6 cases (28%) followed a good evolution with PB only. Two anticonvulsant drugs were used in 11 (52.4%) and 4 (19%) needed one more. They don't reach any relation between etiology of convulsant syndrome, PB doses and serum's levels.
