An Algorithm for the Noninvasive and Personalized Measurement of Microvascular Blood Viscosity Using Physiological Parameters.

Blood viscosity is one of the important parameters to characterize hemorheological properties of the human body. Its real-time and dynamic measurement has important physiological significance for studying the development and prevention of chronic diseases. This study researched noninvasive and personalized measurement of microvascular blood viscosity. In the microcirculation capillary network blood flow model, combined with pulse wave parameters, multiple regression analysis was used to fit the simulated radius of personalized physiological blood vessels to calculate the microvascular blood viscosity. The fitted value related to the simulated radius of the physiological blood vessel had a high correlation with the corresponding theoretically derived value (correlation coefficient: 0.904, P ≤ 0.001). The calculated value of the microvascular blood viscosity had a certain correlation with the clinical whole blood viscosity at a low shear rate (correlation coefficient: 0.443, P < 0.05). This algorithm could provide effective means for noninvasive and long-term individual monitoring and family health care.

The differences in waveform between photoplethysmography pulse wave and radial pulse wave in movement station.

OBJECTIVE: There are many similarities between the photoplethysmography(PPG) pulse wave and the radial pulse when a body is in a stationary state, but the difference between them under conditions of movement is not yet clear. Finding these differences may help further understanding of the cardiovascular system. METHODS: PPG and radial pulse wave were recorded simultaneously while subjects were conducting a bicycle exercise test that included the resting and exercise state, while the K and K' parameters were being acquired from the PPG and radial pulse, respectively. Furthermore, the pulse objective pattern is observed via the time domain waveform and XY graph. RESULTS: When the body's state of movement changes dramatically, there is a time difference between the pulse parameter K and the pulse amplitude, and the difference of the pulse pattern is enhanced during the exercising phase. CONCLUSION: Radial pulse waves are not the same as PPG during exercise in either the pulse parameter or the pulse pattern. This information can be used to further evaluate the state of arterial circulation and microcirculation.

A study of maternal hemodynamic change during healthy pregnancy and women with gestation hypertension.

OBJECTIVE: To investigate the maternal hemodynamic changes that occurs during pregnancy. To find out the difference that lie in healthy pregnancy and women with gestational hypertension. To introduce a method that is applied to shift high-risk women of gestational hypertension in pregnancy women. METHOD: Serial hemodynamic investigations (total 8 times) were performed throughout pregnancy period by radioulnar pulse wave electrical monitoring in 182 women (130 with healthy pregnancies, 52 with gestational hypertension). Analysis of variance with repeated measurements was used to evaluate the course of a number of hemodynamic indices. To identify the correlation between these changes and gestational hypertension by using above method. RESULTS: A significant difference in mean arterial pressure (MAP), cardiac output (CO), cardiac index (CI), total Peripheral Resistance (TPR) and heart rat (HR) was observed different between normal pregnancy and women with gestational hypertension. The changes of parameters in normal woman and gestational hypertension were recorded and the mechanism of gestational hypertension was heterogenous. CONCLUSION: These results provide sensitive parameters for use in early risk assessment and as a guide to preventive intervention during pregnancy.

Dynamic analysis for blood flow parameters of cardiovascular system on work load.

In order to study the dynamic mechanism of blood flow parameters of cardiovascular system on work load, a dynamic mathematical model which can be used to describe quantitatively blood flow parameters of human body on different work load is put forward in this paper. With the help of this model, the correlation of blood flow parameters is studied using the analytic method of function of multiple variables. The experimental results are consistent with the analytic results of dynamic model.