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1.
Cancer Detect Prev ; 24(2): 179-85, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10917140

RESUMO

Cervical intraepithelial neoplasia (CIN) is common in patients positive for human immunodeficiency virus (HIV). The questions are whether the management of CIN in these patients should be different from that of HIV-negative women, whether there are any prognostic factors to indicate the course of CIN, and whether the latter is influenced by antiretroviral therapy. A total of 267 HIV-seropositive women were counseled and examined in our colposcopic clinic. Of that number, 53 patients died during the observation period; 74% of these patients were immunosuppressed (CD4 count < 200 cells/mm3), and 45% were given diagnoses of CIN. The incidence of CIN was significantly higher in patients with CD4 less than 200 cells/mm3. Neither the route of HIV infection nor the HPV status nor smoking habits correlated with CIN. CIN relapse was histologically confirmed in 28% of patients who underwent complete surgical removal. Immune status plays an important role in HIV-positive women not only with respect to survival but with respect to CIN.


Assuntos
Infecções por HIV/complicações , Displasia do Colo do Útero/complicações , Neoplasias do Colo do Útero/complicações , Adulto , Fármacos Anti-HIV/uso terapêutico , Contagem de Linfócito CD4 , Feminino , Infecções por HIV/tratamento farmacológico , Infecções por HIV/imunologia , Humanos , Hospedeiro Imunocomprometido , Prognóstico , Fatores de Risco , Neoplasias do Colo do Útero/epidemiologia , Neoplasias do Colo do Útero/imunologia , Displasia do Colo do Útero/epidemiologia , Displasia do Colo do Útero/imunologia
2.
Int J Biol Macromol ; 25(1-3): 303-6, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10416678

RESUMO

The genes encoding the polyhydroxyalkanoate (PHA) biosynthetic pathway in Ralstonia eutropha (3-ketothiolase, phaA or bktB; acetoacetyl-CoA reductase, phaB; and PHA synthase, phaC) were engineered for plant plastid targeting and expressed using leaf (e35S) or seed-specific (7s or lesquerella hydroxylase) promoters in Arabidopsis and Brassica. PHA yields in homozygous transformants were 12-13% of the dry mass in homozygous Arabidopsis plants and approximately 7% of the seed weight in seeds from heterozygous canola plants. When a threonine deaminase was expressed in addition to bktB, phaB and phaC, a copolyester of 3-hydroxybutyrate and 3-hydroxyvalerate was produced in both Arabidopsis and Brassica.


Assuntos
Acetil-CoA C-Aciltransferase/metabolismo , Aciltransferases/metabolismo , Oxirredutases do Álcool/metabolismo , Arabidopsis/metabolismo , Cupriavidus necator/enzimologia , Poliésteres/metabolismo , Acetil-CoA C-Aciltransferase/genética , Aciltransferases/genética , Oxirredutases do Álcool/genética , Arabidopsis/genética , Cupriavidus necator/genética , Homozigoto , Modelos Moleculares , Estrutura Molecular , Folhas de Planta , Plantas/metabolismo , Plantas Geneticamente Modificadas , Proteínas Recombinantes/metabolismo , Sementes
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