Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3-10 years in China.

Adverse perinatal factors can interfere with the normal development of the brain, potentially resulting in long-term effects on the comprehensive development of children. Presently, the understanding of cognitive and neurodevelopmental processes under conditions of adverse perinatal factors is substantially limited. There is a critical need for an open resource that integrates various perinatal factors with the development of the brain and mental health to facilitate a deeper understanding of these developmental trajectories. In this Data Descriptor, we introduce a multicenter database containing information on perinatal factors that can potentially influence children's brain-mind development, namely, periCBD, that combines neuroimaging and behavioural phenotypes with perinatal factors at county/region/central district hospitals. PeriCBD was designed to establish a platform for the investigation of individual differences in brain-mind development associated with perinatal factors among children aged 3-10 years. Ultimately, our goal is to help understand how different adverse perinatal factors specifically impact cognitive development and neurodevelopment. Herein, we provide a systematic overview of the data acquisition/cleaning/quality control/sharing, processes of periCBD.

Gender-specific resting-state rDMPFC-centric functional connectivity underpinnings of intertemporal choice.

Although studies have observed gender differences in intertemporal choice, the neural bases of these differences require further research. The current study used resting state functional connectivity (rsFC) to explore the gender-specific neural basis of intertemporal choice in three independent samples (n1 = 86, n2 = 297, n3 = 172). Behaviorally, three samples (S1, S2, and S3) consistently demonstrated that men had larger delay discounting rate (log k) than women. Then, whole-brain functional connectivity analyses were performed for different genders in S2 and S3 using the right dorsomedial prefrontal cortex (rDMPFC) as a region of interest. By subtracting the common rsFC patterns of different genders, we identified gender-specific log k-related rsFC patterns with significant gender differences in S2. This was verified in an independent sample (S3). Specifically, in women, log k was found to be positively correlated with the rsFC between rDMPFC and anterior cingulate cortex/right orbitofrontal cortex. In contrast, in men, log k was negatively correlated with rsFC between rDMPFC and left orbitofrontal cortex/right precuneus. These gender differences were confirmed by slope tests. The findings highlight how gender may differ when engaging in intertemporal choice. They improve the understanding of gender differences in decision impulsivity and its underlying neural bases.

Neural differences of food-specific inhibitory control in people with healthy vs higher BMI.

Consistent with the idea that deficits in inhibition limit resistance to tempting, tasty, high-calorie foods, and might result in a higher BMI, we test whether people with higher BMIs (BMI >25 kg/m2) present inefficient inhibitory control over food-related responses. To unpack this association, we also examine individual differences in the neural mechanisms of food inhibitory control in healthy vs higher BMI individuals. We test these aspects with a sample of 109 participants (49 with higher BMI and 60 with healthy BMI) and the food stop-signal task, which was used to examine individuals' inhibitory control. Results demonstrated that people with higher BMI had significantly poorer food inhibitory control than healthy BMI individuals. fMRI results showed that, in both Go (Go_food vs Go_nature) and Stop conditions (Stop_food vs Stop_nature), compared to healthy BMI individuals, individuals with higher BMI had lower activation in the superior frontal gyrus, precuneus, precentral gyrus, and supramarginal gyrus in the food stimulus condition. Moreover, ROI analysis results showed that under the Stop_food condition, the activation in the inferior frontal gyrus in the higher BMI group was significantly negatively correlated with inhibitory control abilities. These results suggest that people with a higher BMI have limited ability to inhibit food impulsions, and that the prefrontal regions and parietal cortex may contribute to the progression of inhibitory control limitations in relation to food.

Risk aversion in risk-taking tasks: Combined effects of feedback attributes and cognitive reflection ability.

INTRODUCTION: Feedback on human choices is important because it can affect risk-taking and rationality in subsequent decisions. In daily life, choices are not always followed by immediate outcomes nor are they always followed by simple, single-dimensional feedback. Here, we seek to extend previous studies on the effects of feedback on subsequent risk-taking in three experiments. METHODS: We examine whether (1) the effect of feedback immediacy on participants' risk-taking exists in tasks containing explicit probabilistic outcome values; (2) increasing feedback dimensionality from one dimension (only about the outcome) to include a second dimension (also about the "rationality" of prior choices) increases feedback effects on risk-taking; and (3) cognitive reflection ability moderates feedback effects on risk-taking. RESULTS: Results showed that feedback reduced risk-taking in tasks containing explicit probabilistic outcomes (Studies 1 and 2). They further showed that two-dimensional feedback produces a stronger reduction in risk-taking compared to single-dimensional feedback (Study 3). Lastly, results suggested that cognitive reflection ability moderates the effects of feedback on risk-taking (Study 4). CONCLUSION: Taken together, the findings extended the understanding of risk-taking and mitigating mechanisms and pave the way for intervention studies aimed at changing risky behaviors.

The Onset of Menstruation and Social Networking Site Use in Adolescent Girls: The Mediating Role of Body Mass Index.

Evidence suggests that girls spend much time on social networking sites (SNS), often more than boys do. It has been proposed that this may have to do with sex-based differences in the need and approaches for socialization. We posit that adolescent girls are also unique in that they are developing physiologically and start menstruating. Based on prior research, we hypothesize that the onset of menstruation can drive physiological changes (increased body mass index (BMI)), which together with common behavioral-psychological (social and emotional) responses to menstruation can contribute to an increase in SNS use. We therefore aim to test whether BMI partially mediates the relationship between menstruation and SNS use in adolescent girls. Results based on a large nationally representative sample in the United Kingdom suggest that the age of menarche was negatively associated with daily hours of SNS use, and that BMI elevation partially mediated this association. These results extend the negative effects of the early onset of menstruation and imply that BMI control strategies may help to reduce the use of SNS in girls who experience menarche at an earlier age.

Activation patterns of the dorsal medial prefrontal cortex and frontal pole predict individual differences in decision impulsivity.

Intertemporal choice refers to decisions that need to weigh different rewards at different time points in the future. Decision impulsivity manifests in the tendency of choosing smaller immediate options rather than larger later ones. Previous studies have suggested that decision impulsivity in intertemporal decision-making shares similar cognitive and neural mechanisms with risky decision-making. The present study theorizes on and examines whether the activation patterns of the dorsal medial prefrontal cortex (DMPFC) and the frontal pole (FP) during the risk-taking "cups task", as captured in the scanner, can predict the delay discounting rate (k) based on an intertemporal decision task performed outside the scanner. To this end, we scanned with functional magnetic resonance imaging (fMRI) techniques a sample of 257 college students (N = 257) while performing the cups task. Univariate analyses showed that activation levels of the DMPFC and the FP were inversely correlated with risk preference, but not with the delay discounting rate k. Multivariate pattern analysis, which can overcome key limitations of the univariate analyses, showed that activation patterns of these two regions predict the delay discounting rate k. These results confirmed the important roles of DMPFC and FP in decision impulsivity and the utility of using multivariate pattern analysis with fMRI data involving decision making tasks.

Dissociable fronto-striatal functional networks predict choice impulsivity.

Fronto-striatal structural connectivity is associated with choice impulsivity. Yet, to date, whether distinct fronto-striatal functional coupling associates with impulsive choices are largely unknown. Using seed-based resting-state functional MRI (rsfMRI) combined with multivariate pattern analysis (MVPA), the present study aimed to explore the predictions of dissociable frontal-striatal functional connectivity on choice impulsivity in a relatively large sample (N = 429). Adaptive delay-discounting task was utilized to assess choice impulsivity and the striatum was further divided into three subregions including the nucleus accumbens (NAcc), caudate, and putamen. Results revealed that both the functional coupling between the NAcc and the limbic/dorsolateral prefrontal cortex, and between the caudate and the dorsal prefrontal cortex, including the dorsomedial prefrontal cortex (DMPFC), successfully predicted the delay-discounting rate. However, such pattern was not observed in the putamen-prefrontal functional connectivity. These findings suggest fronto-striatal-dependent neural mechanisms of choice impulsivity and further provide a better understanding of the contributions of striatum subregions and their functional connectivities with different areas of prefrontal cortex upon inter-temporal choice.

The regional homogeneity patterns of the dorsal medial prefrontal cortex predict individual differences in decision impulsivity.

Intertemporal choice refers to the process of making decisions by weighing short- and long-term benefits and costs. On average people prefer immediate rewards over delayed rewards with larger amounts, which is a form of decision impulsivity. Based on previous research showing the importance of the dorsal medial prefrontal cortex (DMPFC) in decision impulsivity, the present study examined whether regional homogeneity (ReHo) patterns in DMPFC were associated with individual differences in intertemporal choices. Two cohorts of college students (N = 239 and N = 227, respectively) were recruited and resting-state data were collected. Results from both univariate and multivariate pattern analyses of the two cohorts consistently showed that ReHo patterns in the DMPFC were associated with the delay discounting rate (i.e., log k). These results further support the important role of DMPFC in intertemporal choice and have potential practical implications for decision making in our daily life and at the level of national policies as well as for the treatment of clinical populations with decision impulsivity (e.g., gamblers, individuals with substance use disorders).

Cathodal stimulating the left DLPFC changes risk disposition toward common risky behaviors in daily-life.

Many daily activities require the weighting of risks and gains, and adjusting decisions based on this information. The present study investigates the role of left DLPFC in such normal-life, routine, but risky decisions. We expected that down-regulating the left DLPFC will reduce emphasis on gains such that less-riskier decisions, as captured with attitude and behavioral intention measures, are made. In study 1 (n = 56), tDCS naïve participants were recruited and subjected to high-definition cathodal tDCS stimulation (with intensity of 1.5 mA for 20 min) of the left DLPFC. A single-blind within-subject pre-post design was employed, in which each subject responded to realistic, normal life, risky decision and control scenarios, before and after stimulation. In study 2 (n = 60), we added a between-subjects factor by assigning half of the participants to a sham stimulation condition. Results were consistent across studies. They demonstrated significantly reduced attitudes and intentions toward risky behaviors, and no significant changes in attitudes and intentions toward control behaviors. Study 2 showed that the reductions were significantly larger in the tDCS stimulation group than in the sham group. These results highlight the role of the left DLPFC in mediating common daily risky behaviors.