RESUMO
Interstitial keratitis is defined as nonulcerative inflammation of the corneal stroma resulting from a bacterial or viral infection, parasitic antigen, or autoimmune response. Hidradenitis suppurativa is an inflammatory skin condition that presents with painful and inflamed boils in apocrine gland-bearing regions of the body, typically with onset around puberty, and ocular comorbidities exist in only a small percentage of these patients. Herein, we describe a unique ocular presentation of hidradenitis suppurativa including pronounced bilateral interstitial keratitis and association with high titer c-ANCA (antineutrophil cytoplasmic antibodies).
RESUMO
Preserving the functionality of nanosensors is critical for their reliable performance under harsh environmental conditions. Biofunctionalized plasmonic nanostructures are an important class of bionanoconjugates for biosensing, bioimaging, and nanotherapeutics. Plasmonic nanostructures and biomolecules exhibit poor thermal stability over time. Here, we report a class of metal-organic framework, zeolitic imidazolate framework-8 (ZIF-8), as a protective coating for preserving plasmonic nanostructures and plasmonic bionanoconjugates at elevated temperature. Gold nanobipyramids (AuNBPs) with sharp tips are attractive plasmonic nanotransducers with high sensitivity but are prone to structural change and loss of sensitivity. This work reports the first observation that ZIF-8 can preserve the structure of AuNBPs and their corresponding strong electromagnetic field enhancement and high refractive index sensitivity. In addition, ZIF-8 coating enables nearly 100% retention of biorecognition capability of antibodies immobilized on the AuNBP surface after exposure to 60 °C for 48 h. The efficacy, versatility, and facile implementation of ZIF-8 coating offer great promise for the preservation of nanosensors.
