RESUMO
Purpose: The impact of SARS-CoV-2 infection on pre-existing retinal pathology is currently unknown. Observations: We present a unique case of rapidly progressing diabetic retinopathy (DR) following severe COVID-19 infection requiring supplemental oxygen and subsequent long-COVID. Conclusions and importance: Following infection with SARS-CoV-2, the associated acute and possible long-term hypoxia has the potential to affect the retina and accelerate the natural course of diabetic retinopathy.
RESUMO
Several studies have investigated how lifetime cognitive engagement affects levels of amyloid-beta (Aß) deposition in the brain. However, there has been some disagreement, leaving the relationship of cognitive activity (CA) to Aß a largely open question. The present study investigated the relationship between CA, Aß deposition, and glucose metabolism. One hundred nine cognitively normal participants underwent Pittsburgh Compound-B (PiB) and [18F]fluorodeoxyglucose-positron emission tomography and completed a questionnaire designed to measure current CA. Statistical analyses revealed significant differences in PiB retention between those in the high and low CA groups. Linear regression models revealed a significant negative relationship between PiB retention and CA and a significant positive relationship between glucose metabolism and CA. These data suggest that CA may have a direct beneficial effect on the pathophysiology of AD or reflect another underlying process that results in both higher CA and lower AD pathophysiology.