Dual source-powered multifunctional Pt/FePc@Mn-MOF spindle-like Janus nanomotors for active CT imaging-guided synergistic photothermal/chemodynamic therapy.

Nanomaterials capable of dual therapeutic effects of chemodynamic therapy (CDT) and photothermal therapy (PTT) is an efficacious strategy in cancer treatment. It is still a challenge to achieve complete apoptosis of tumor tissue in CDT/PTT due to the poor permeability of nanomaterials in tumor tissue. Herein, we prepared a dual-source driven Pt/FePc@Mn-MOF spindle-like Janus nanomotor by a facile oriented connection growth method for computed tomography (CT) imaging-guided CDT and PTT. The high catalase (CAT)-like activity of nanomotors allows the generation of oxygen (O2) bubbles by catalyzing the decomposition of endogenous H2O2, which alleviates the hypoxic state of the tumor microenvironment (TME) and simultaneously drive nanomotors. Pt/FePc@Mn-MOF nanomotor with excellent photothermal conversion efficiency exhibited dual peroxidase (POD)-like and oxidase (OXD)-like activities, which can produce large amounts of ROS to obtain PTT enhanced CDT. Meanwhile, near-infrared light, as "optical brakes", can trigger Janus nanomotor to realize self-thermophoretic movement. Chemical/NIR-assisted autonomous propulsion can significantly improve the accumulation of Janus nanomotors in solid tumors and enhance their ability to penetrate tumor tissue, thus brings synergistic enhancement effect to PTT and CDT. Moreover, Mn-MOF in nanomotor can deplete the antioxidant GSH by redox reaction to release massive Mn2+, which introduce Mn2+-based CT imaging properties. This novel dual-source controlled Janus nanomotor offers great potential for multimodal therapeutic medical applications.

Hierarchical hollow α-Fe2O3/ZnFe2O4/Mn2O3 Janus micromotors as dynamic and efficient microcleaners for enhanced photo-Fenton elimination of organic pollutants.

Micro/nanomotors that can promote mass transport have attracted more and more research concern in the photocatalysis field. Here we first report a newly-designed hierarchical α-Fe2O3/ZnFe2O4/Mn2O3 magnetic micromotor as a heterogeneous photocatalyst for the degradation of cationic dye methylene blue (MB) from wastewater. The resulting three-dimensional (3D) flower-like hollow Janus micromotors are fabricated through a green and scalable strategy, in which each component has different functions. ZnFe2O4 microspheres serve as a magnetic scaffold for the nucleation and growth of α-Fe2O3 nanosheets and for the recycling of the micromachine. α-Fe2O3 nanosheets have shown great potential as an ideal semiconductor material for the photocatalytic decontamination of pollutants. Mn2O3 nanoparticles are mainly utilized as a catalyst to produce O2 bubbles to propel the autonomic movement of the micromotors in the presence of H2O2 fuel and also as a Fenton-like catalyst to decompose H2O2 to generate reactive oxygen species. Furthermore, the resultant micromotors exhibited linear-like motion form with an average speed of 189.1 µm s-1 in 5 wt% H2O2 solution. Moreover, the self-driven micromotors exhibited a superior catalytic degradation property toward MB, which was attributed to the synergistic effect of heterogeneous photocatalyst and the boosted micro-mixing and mass transfer caused by the vigorous motion of the micro-actuator. The possible degradation intermediates and passways of MB by α-Fe2O3/ZnFe2O4/Mn2O3 micromotor were identified with time of flight mass spectroscopy (TOF-MS). The 3D Janus micromotors have the potential to be used as a high-efficiency and active heterogeneous photocatalyst for the degradation of organic pollutants.

NIR-propelled Janus nanomotors for active photoacoustic imaging and synergistic photothermal/chemodynamic therapy.

Synthetic nanomotors have great application potential in deep tissue imaging and tumor treatment due to their active movement ability. Herein, a novel near infrared (NIR) light-driven Janus nanomotor is reported for active photoacoustic (PA) imaging and synergistic photothermal/chemodynamic therapy (PTT/CDT). Au nanoparticles (Au NPs) are sputtered on the half-sphere surface of copper-doped hollow cerium oxide nanoparticles after bovine serum albumin (BSA) modification. Such Janus nanomotors exhibit a rapid autonomous motion with a maximum speed of 110.6 ± 0.2 µm/s under 808 nm laser irradiation with a density of 3.0 W/cm2. With the assistance of light-powered motion, the Au/Cu-CeO2@BSA nanomotors (ACCB Janus NMs) can effectively adhere to and mechanically perforate tumor cells, thereby causing the higher cellular uptake and significantly enhancing the tumor tissue permeability in the tumor microenvironment (TME). ACCB Janus NMs also exhibit high nanozyme activity that can catalyze the production of reactive oxygen species (ROS) to reduce the TME oxidative stress response. Meanwhile, the potential PA imaging capability of ACCB Janus NMs offer promise for early diagnosis of tumors due to the photothermal conversion efficiency of Au NPs. Therefore, the nanotherapeutic platform provides a new tool for effectively imaging of deep tumors site in vivo to achieve synergistic PTT/CDT and accurate diagnosis.

3D hierarchical LDHs-based Janus micro-actuator for detection and degradation of catechol.

Micro/nanomotors that combine the miniaturization and autonomous motion have attracted much research interest for environmental monitoring and water remediation. However, it is still challenging to develop a facile route to produce bifunctional micromotors that can simultaneously detect and remove organic pollutants from water. Herein, we developed a novel Janus micromotor with robust peroxide-like activity for simultaneously colorimetric detection and removal of catechol from water. Such laccase (Lac) functionalized Janus micromotor consisted of calcined MgAl-layered double hydroxides (MgAl-CLDHs) nanosheets and Co3O4-C nanoparticles (Lac-MgAl-CLDHs/Co3O4-C), revealing unique 3D hierarchical microstructure with highly exposed active sites. The obtained Janus micromotors exhibited autonomous motion with a maximum velocity of 171.83 ± 4.07 µm/s in the presence of 7 wt% H2O2 via a chemical propulsion mechanism based on the decomposition of H2O2 by Co3O4-C layer on the hemisphere surface of Janus micromotors. Owing to the combination of autonomous motion and high peroxide-like activity, Lac-MgAl-CLDHs/Co3O4-C Janus micromotors could sensitively detect catechol with the limit of detection of 0.24 µM. In addition, such Janus micromotors also could quickly degrade catechol by •OH generated from a Fenton-like reaction. It is a first step towards using autonomous micromotors for highly selective, sensitive, and facile detection and quick removal of catechol from water.

Three-Dimensional Hierarchical HRP-MIL-100(Fe)@TiO2@Fe3O4 Janus Magnetic Micromotor as a Smart Active Platform for Detection and Degradation of Hydroquinone.

A novel multifunctional Janus magnetic micromotor was designed and constructed by using MIL-100(Fe)@TiO2@Fe3O4 multicore-shells modified with horseradish peroxidase (HRP) as a smart active platform to realize detection and degradation of hydroquinone (HQ). The obtained micromotor showed a unique three-dimensional (3D) hierarchical architecture with highly exposed active sites and could autonomously move at a speed of 140 ± 7.0 µm·s-1 by O2 bubbles generated from the catalytic decomposition of H2O2 fuel. Benefiting from the combination of active self-propulsive motion, high peroxidase-like activity, tuned heterojunctions with matching band structures, and a 3D hierarchical structure, an effective platform involving dynamically sensitive detection and quick removal of HQ from water was established by using the multifunctional HRP-integrated MIL-100(Fe)@TiO2@Fe3O4 Janus micromotor. The proposed multifunctional Janus magnetic micromotor had advantages of simple and feasible fabrication, sensitive detection and effective photo-Fenton degradation of HQ in a wide pH range of 4-7, and magnetic recycling, revealing potential for environmental remediation applications.