Anterior chamber angle width, central vault and intraocular pressure changes after 12 months of Visian collamer lens implantation.

PURPOSE: To evaluate 1-year changes of vault, anterior chamber angle width (ACAW) and intraocular pressure (IOP) after the implantation of implantable collamer lens (ICL) V4c in high myopic patients. METHODS: Sixty ICL V4c implantation surgeries were included. Patients underwent surgery between January 2014 and June 2017 at Ophthalmology Center Tecnolaser Clinic Vision®, Seville, Spain. All patients had a 12-month follow-up. A preoperative spherical equivalent between - 4.00 and - 15.00 D was established as inclusion criterion. ACAW and vault were measured with Pentacam single rotation Scheimpflug camera (Oculus Optikgeräte GmbH, Wetzlar, Germany). IOP was measured with CORVIS ST (Oculus Optikgeräte GmbH, Wetzlar, Germany). RESULTS: One-day vault was 553.17 ± 169.80 [268-975] µm; 12-month vault was 515.67 ± 176.46 [169-950] µm (p < 0.01). Preoperative ACAW was 36.85° ± 4.60° [26.7°-46.8°]; postoperative ACAW was 25.98° ± 3.85° [16.4°-32.6°] (p < 0.01). Preoperative IOP was 15.37 ± 1.58 [12.0-18.3] mmHg, postoperative IOP was 15.61 ± 1.60 [12.0-19.0] mm Hg (p = 0.35). CONCLUSIONS: ICL V4c lens experienced a progressive reduction of vault after 12-month follow-up. ACAW decrease was significant between preoperative and postoperative values. We propose to include a minimum preoperative ACAW and an IOP correction factor for lens size.

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Effect of regenerative factor rich plasma, P substance and fetal calf serum on the growth of epithelial cells in the cornea. Comparative experimental study.

PURPOSE: The goal of this study was to evaluate the experimental effectiveness of Regenerative Factor Rich Plasma (RFRP) of human blood versus Fetal Bovim Serum (FBS) and neuropeptide Substance P (SP) on corneal epithelium cell proliferation. METHOD: Rabbit corneal epithelium cell (CCL-60) growth was compared between different RFRP fractions, FBS and with the neuropeptide Substance P. The ability of the RFRP fractions and SP to revert the inhibitory effect of the CsA was also evaluated. RESULTS: All groups showed an increase (p<0.001) in corneal epithelial cell growth compared with the control group. The maximum capacity of cell growth was obtained with dilutions of 50% in the FBS, RFRP-I, RFRP -II, RFRP-III groups and with 100nM of SP. The highest growth was observed with 50% FBS, RFRP-I and RFRP-II. The group with SP and RFRP-III had significantly lower growth (p<0.001). When the NK1 receptor antagonist CsA was added at a dose of IC50, we found a significant decrease in cell growth (p<0.001) in all culture conditions, including the control group. The decrease was similar in all groups, but was especially pronounced in RFRP-II. RFRP I, II and III promoted growth more than SFB 10%. CONCLUSION: The RFRP of human blood promotes the growth of corneal epithelial cells in a significantly more efficient manner than FBS and SP. RFRP can be effective both in cell cultures and stem cell cultures.

Subconjunctival application of regenerative factor-rich plasma for the treatment of ocular alkali burns.

PURPOSE: To study the efficiency of the subconjunctival application of autologous regenerative factor-rich plasma (RFRP) in patients with different degrees of ocular alkali burns. METHODS: Thirty-five eyes of 35 patients with ocular alkali burns were analyzed. They were classified into moderate and relevance groups according to the severity of the burn. A control group was established for each with conventional topical medical treatment; subconjunctival regenerative factor rich plasma (RFRP) was applied to the other groups. A further group was added to the severe chemical burn group, which received autohemotherapy. The clinical evolution of the lesions and the period in which the pathology prevented the patient from working were studied; monitoring was carried out until the patient had healed. RESULTS: In the moderate chemical burns, there was a significant reduction in corneal and conjunctival epithelization times, sick leave duration, and healing time when the patients were treated with RFRP in comparison to the control group. With regard to the severe burns, significant reduction in time to corneal scarring in those treated with RFRP in comparison to traditional treatment was reported. RFRP showed, at least as effective and less side effects than the autohemotherapy. CONCLUSIONS: Subconjunctival infiltration with autologous RFRP can be considered an effective, straightforward, and economical form of treatment for burns of the ocular surface.