[On the influence of D-penicillamine on collage metabolism - investigations of the rupture of strength in tailfibre in rats of several ages (author's transl)]. / Zum Einfluss von D-Penicillamin auf der Kollagenstoffwechsel - Reissfestikeitsuntersuchungen an Schwanzsehnen verschieden alter Ratten.

The tensile strength of rat tail tendons of animals wtih a different age is more influenced by D-Penicillamine (DPA) in younger rats than in elderly rats. DPA has the best effect in the regions with the highest collagen turnover. After the use of DPA the collagen of tails of the elderly rats resembles the collagen of the younger animals. The reason of this alteration is probably a lower degree of cross-links of the collagen after the use of DPA.

Bone diseases in advanced and old age: diagnostics, prophylaxis, therapy.

The authors give a short overview on:--Diseases characterized by too small a number of osteoblasts and insufficient osteoid formation--Bone diseases in the presence of osteoid overproduction with concomittant disturbed mineralization can quasi be summed up in two statements as regards ageing and aged people--Diseases associated with excessive resorption due to increased osteoclastic activity--Diseases caused by great resorption of bone in the presence of bone marrow proliferation, their diagnostics, prophylaxis and therapy.

[Studies on anesthetized and unanesthetized slaughter pigs. 2. Behavior of the electrocardiogram]. / Untersuchungen an betäubten und nicht betäubten Schlachtshweinen 2. Mitteilung: Verhalten des Elektrokardiogramms.

Electrocardiographic tests were applied to slaughter pigs and showed continuous rise of the heart rate from anaesthetisation to the debleeding prick at which point its maximum was 86% beyond the original value. The duration of the intraventricular electric systoles was 0.290 s prior to the debleeding prick and 0.281 s thereafter. The intraventricular electric diastoles were 0.241 s prior to debleeding and 0.303 s after it. No significant modification in diastolic time was observed prior to the debleeding prick. ST duration dropped from an original level of 0.222 s to a minimum of 0.173 at the point of pricking.

On the effect of prednisolone on hamster bone.

Over a period of 10.8 weeks 0.4, 4.0 or 40.0 mg, respectively of prednisolone bisuccinate/kg/day were injected intramuscularly into Syrian golden hamsters with a body weight of about 100 g. The dosage of 4.0 mg of prednisolone/kg did not produce any osteoporotic changes. The modulus of elasticity and the fracture load of the bones under investigation did not differ from the values obtained in control animals. At a dosage of 0.4 mg of prednisolone/kg/day the values of analysis (density, ash/cm3, calcium/cm3 and hydroxyproline/cm3) decreased by 5-8 percent, and at a dosage of 40.0 mg of prednisolone/kg/day even by 20-34 per cent as compared with the control group. The modulus of elasticity and the fracture load were significantly changed.