Healthcare workers perceptions of patient safety culture in selected Ghanaian regional hospitals: a qualitative study.

BACKGROUND: Patient safety culture is an integral part of healthcare delivery both in Ghana and globally. Therefore, understanding how frontline health workers perceive patient safety culture and the factors that influence it is very important. This qualitative study examined the health workers' perceptions of patient safety culture in selected regional hospitals in Ghana. OBJECTIVE: This study aimed to provide a voice concerning how frontline health workers perceive patient safety culture and explain the major barriers in ensuring it. METHOD: In-depth semi-structured interviews were conducted with 42 health professionals in two regional government hospitals in Ghana from March to June 2022. Participants were purposively selected and included medical doctors, nurses, pharmacists, administrators, and clinical service staff members. The inclusion criteria were one or more years of clinical experience. Interviews were recorded and transcribed. Thematic analysis was used to identify themes. RESULT: The health professionals interviewed were 38% male and 62% female, of whom 54% were nurses, 4% were midwives, 28% were medical doctors; lab technicians, pharmacists, and human resources workers represented 2% each; and 4% were critical health nurses. Among them, 64% held a diploma and 36% held a degree or above. This study identified four main areas: general knowledge of patient safety culture, guidelines and procedures, attitudes of frontline health workers, and upgrading patient safety culture. CONCLUSIONS: This qualitative study presents a few areas for improvement in patient safety culture. Despite their positive attitudes and knowledge of patient safety, healthcare workers expressed concerns about the implementation of patient safety policies outlined by hospitals. Healthcare professionals perceived that curriculum training on patient safety during school education and the availability of dedicated officers for patient safety at their facilities may help improve patient safety.

A Cysteine-Maleimide-Based Design for Hemostatic, Antibacterial, and Biodegradable Wound Dressing.

The field of clinical surgery frequently encounters challenges related to atypical wound tissue healing, resulting in the development of persistent chronic wounds or aesthetically displeasing scar tissue. The use of wound dressings crafted from mussel adhesive proteins and hyaluronic acid has demonstrated the potential in mitigating these undesirable outcomes. However, the synergistic effects of these two biomaterials remain underexplored. In this study, we have engineered a versatile, degradable, and biocompatible dressing that comprises recombinant 3,4-dihydroxyphenylalanine (DOPA)-modified mussel adhesive proteins and maleimide-functionalized hyaluronic acid. We have successfully fabricated this biocompatible dressing and conducted comprehensive experimental assessments to confirm its hemostatic, antibacterial, and biocompatible characteristics. Importantly, this dressing exclusively incorporates biologically derived materials characterized by low toxicity and minimal immunogenicity, thus holding immense promise for clinical applications in the field of wound healing.

Computational design towards a boiling-resistant single-chain sweet protein monellin.

Sweet proteins offer a promising solution as sugar substitutes by providing a sugar-like sweetness without the negative health impacts linked to sugar or artificial sweeteners. However, the low thermal stability of sweet proteins has hindered their applications. In this study, we took a computational approach utilizing ΔΔG calculations in PyRosetta to enhance the thermostability of single-chain monellin (MNEI). By generating and characterizing 21 variants with single mutation, we identified 11 variants with higher melting temperature (Tm) than that of MNEI. To further enhance the thermal stability, we conducted structural analysis and designed an additional set of 14 variants with multiple mutations. Among these variants, four exhibited a significant improvement in thermal stability, with an increase of at least 20 °C (Tm > 96 °C) compared to MNEI, while maintaining their sweetness. Remarkably, these variants remained soluble even after being heated in boiling water for one hour. Moreover, they displayed exceptional stability across alkaline, acidic and neutral environments. These findings highlight the tremendous potential of these variants for applications in the food and beverage industry. Additionally, this study provides valuable strategies for protein engineering to enhance the thermal stability of sweet proteins.

The need for digital health education among next-generation health workers in China: a cross-sectional survey on digital health education.

BACKGROUND: Digital health is important for sustainable health systems and universal health coverage. Since the outbreak of COVID-19, many countries, including China, have promoted the introduction of digital health in their medical services. Developing the next generation of physicians with digital health knowledge and skills is a prerequisite for maximizing the potential of digital health. OBJECTIVE: We aimed to understand the perception of digital health among Chinese medical students, the current implementation of digital health education in China, and the urgent need of medical students. METHODS: Our cross-sectional survey was conducted online and anonymously among current medical students in China. We used descriptive statistical analysis to examine participant demographic characteristics and the demand for digital health education. Additional analysis was conducted by grouping responses by current participation in a digital health course. RESULTS: A total of 2122 valid responses were received from 467 medical schools. Most medical students had positive expectations that digital health will change the future of medicine. Compared with wearable devices (85.53%), telemedicine (84.16%), and medical big data (86.38%), fewer respondents believed in the benefits of clinical decision support systems (CDSS) (63.81%). Most respondents said they urgently needed digital health knowledge and skills, and the teaching method of practical training and internship (78.02%) was more popular than the traditional lecture (10.54%). However, only 41.45% wanted to learn about the ethical and legal issues surrounding digital health. CONCLUSIONS: Our study shows that the current needs of Chinese medical students for digital health education remain unmet. A national initiative on digital health education, is necessary and attention should be paid to digital health equity and education globally, focusing on CDSS and artificial intelligence. Ethics knowledge must also be included in medical curriculum. Students as Partners (SAP) is a promising approach for designing digital health courses.

Corrigendum to "Overview and analysis of the text mining applications in the construction industry" [Heliyon 8 (12) (December 2022) Article e12088].

[This corrects the article DOI: 10.1016/j.heliyon.2022.e12088.].

Overview and analysis of the text mining applications in the construction industry.

The data generation in the construction industry has increased dramatically. The major portion of the data in the architecture, engineering and construction (AEC) domain are unstructured textual documents. Text mining (TM) has been introduced to the construction industry to extract underlying knowledge from unstructured data. However, few articles have comprehensively reviewed applications of TM in the AEC domain. Thus, this study adopts a qualitative-quantitative method to conduct a state-of-the-art survey on the articles related to applications of TM in the construction industry which published between the year of 2000 and 2021. VOSviewer software was applied to provide an overview of TM applications regarding to the publication trend, active countries and regions, productive authors, and co-occurrence of keywords perspectives. Eight prime application fields of TM were discussed and analyzed in detail. Five key challenges and three future directions have been proposed. This review can help the research community to grasp the state-of-the-art of TM applications in the construction industry and identify the directions of further research.

Evolution of Bio-Inspired Artificial Synapses: Materials, Structures, and Mechanisms.

Artificial synapses (ASs) are electronic devices emulating important functions of biological synapses, which are essential building blocks of artificial neuromorphic networks for brain-inspired computing. A human brain consists of several quadrillion synapses for information storage and processing, and massively parallel computation. Neuromorphic systems require ASs to mimic biological synaptic functions, such as paired-pulse facilitation, short-term potentiation, long-term potentiation, spatiotemporally-correlated signal processing, and spike-timing-dependent plasticity, etc. Feature size and energy consumption of ASs need to be minimized for high-density energy-efficient integration. This work reviews recent progress on ASs. First, synaptic plasticity and functional emulation are introduced, and then synaptic electronic devices for neuromorphic computing systems are discussed. Recent advances in flexible artificial synapses for artificial sensory nerves are also briefly introduced. Finally, challenges and opportunities in the field are discussed.

Challenges in current construction and demolition waste recycling: A China study.

China produced a large amount of construction and demolition (C&D) waste, owing to the rapid development of construction industry. Although a set of policies and regulations are being drafted in China for promoting C&D waste recycling, execution of these policies in practice seems to be far from effective. Currently, approximately 75% of Chinese cities are still surrounded by large volumes of C&D waste. Therefore, identification of challenges in the development of C&D waste management, specially recycling, is essential. This paper employs site visits to 10 recycling plants in 10 Chinese cities (Shanghai, Hangzhou, Suzhou, Chongqing, Chengdu, Xi'an, Changsha, Shenzhen, Nanjing, and Zhoukou) and interviews with 25 industry practitioners for examining the challenges. Eight challenges are identified: (1) unstable source of C&D waste for recycling, (2) absence of subsidies for recycling activities and high cost for land use, (3) insufficient attention paid to design for waste minimisation, (4) absence of regulations on on-site sorting, (5) unregulated landfill activities, (6) a lack of coordination among different government administration departments, (7) a lack of accurate estimation of waste quantity and distribution, and (8) a lack of an effective waste tracing system. Recommendations to address these challenges are presented. The results of this study are expected to aid policy makers in formulation of proper C&D waste management in China and provide a useful reference for researchers who are interested in C&D waste recycling industry.

Mixed receptors of AMPA and NMDA emulated using a 'Polka Dot'-structured two-dimensional conjugated polymer-based artificial synapse.

In a biological synapse, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors mediate fast excitatory neurotransmission, whereas N-methyl-d-aspartate (NMDA) receptors trigger an enhanced memory effect; the complementary roles of AMPA and NMDA are essential in short-term plasticity (STP) to enhance memory effect (EME) transition. Herein, we report the design and fabrication of the first two-dimensional (2D) conjugated polymer (CP)-based synaptic transistor. The special design of the 2D CP with nanoscale-segregated 'polka dot'-structured crystalline phases and adjacent amorphous phases emulate the different receptors of NMDA and AMPA on the postsynaptic membrane for the first time. The synergistic effect of mixed receptors distinguishes STP and enhanced memory effect with a critical point, which regulates the threshold level of the enhanced memory effect induction. This effect has not been reported yet. The special structure avoids easy saturation of a single receptor with consecutively increased excitatory postsynaptic current (EPSC) in response to 1200 stimuli. Furthermore, the 2D P3HT synapse successfully emulates activity-dependent synaptic plasticity, such as metaplasticity and homeostatic plasticity, which are advanced forms of plasticity, allowing the self-adaptive ability of a synapse, but have rarely been reported.

Artificial synapses based on nanomaterials.

Artificial synapses emulate biological synaptic signals in neuromorphic systems to attain brain-like computation and autonomous learning behaviors in non-von-Neumann systems. Several classes of materials have been applied to this field to achieve numerous functionalities of biological synapses. Nanomaterials (NMs), such as one-dimensional (1D) and two-dimensional (2D) NMs have shown great potential due to their nanometer feature size (1D) and molecular-level thickness (2D). In this paper, we review the development of artificial synapses, and discuss state-of-the-art artificial synapses based on NMs.