Amniotic fluid index as a predictor of latency after preterm premature rupture of the membranes.

To determine if latency following preterm premature rupture of membranes can be predicted using the amniotic fluid index, a retrospective observational study was performed using patient records to identify those admitted with a diagnosis of preterm premature rupture of membranes. Fifty-one patients with initial evaluation within 48 hours of rupture and gestational age 26 to 34 weeks were identified. Amniotic fluid index was evaluated along with a biophysical profile; these were followed serially until delivery. Delivery was accomplished because of spontaneous labor or chorioamnionitis. Amniotic fluid index at initial evaluation was stratified into three groups: Low (less than 5.0), reduced (4.0 to 7.9), and normal (8.0 or higher). Latency in days from preterm premature rupture of membranes to delivery was evaluated for these groups. A difference was noted in that latency was significantly longer in the group with normal versus low or reduced amniotic fluid index groups. The amount of residual amniotic fluid, as measured by the amniotic fluid index, following preterm premature rupture of membranes, is predictive of latency.

Pharmacokinetics of fluorouracil in humans.

A high-pressure liquid chromatography method has been used to investigate the pharmacokinetics of fluorouracil after single i.v. doses to patients. The method is simple and is specific for fluorouracil. No interference was observed in fluorouracil determinations due to other administered medication. Plasma levels of fluorouracil declined rapidly after dosing. The mean half-life was 11.4 min, and drug was essentially cleared from plasma in 1 hr. Individual differences in plasma fluorouracil levels, and also in derived pharmacokinetic constants, were considerably less than those reported previously.