RESUMO
At the present time there is a growth in the number of children suffering from chronic viral hepatitis (CVH). The most difficult group consists of patients with mixed-hepatitis, which is associated with a more rapid progression of the disease and the formation of cirrhosis of the liver. The paper presents the data of long-term monitoring of children with chronic hepatitis B+C (CH B+C); it demonstrates the features of a clinical course, the nature of the biochemical, immunologic, and morphologic changes in the natural course of the disease.
Assuntos
Hepatite B Crônica/complicações , Hepatite B Crônica/diagnóstico , Hepatite C Crônica/complicações , Hepatite C Crônica/diagnóstico , Fígado/patologia , Autoanticorpos/sangue , Biomarcadores/sangue , Biópsia , Criança , DNA Viral/genética , Endoscopia do Sistema Digestório , Feminino , Hepacivirus/isolamento & purificação , Anticorpos Anti-Hepatite B/sangue , Vírus da Hepatite B/isolamento & purificação , Hepatite B Crônica/sangue , Hepatite B Crônica/patologia , Anticorpos Anti-Hepatite C/sangue , Hepatite C Crônica/sangue , Hepatite C Crônica/patologia , Humanos , Testes de Função Hepática , Masculino , Reação em Cadeia da Polimerase , RNA Viral/genética , Fatores de TempoRESUMO
The case report describes a progressive familial intrahepatic cholestasis II type Byler's syndrome with structural abnormality of the bile canalicular membrane. A child with a rare hereditary pathology,who is on the waiting list for liver transplantation, on the background of complex treatment, including diet therapy, drug therapy achieved a positive dynamics of clinical and laboratory parameters, acceleration of physical, psychomotor and intellectual development, that in general has improved the surgery prognosis and quality of life of the patient.