RESUMO
Indole and its derivatives undergo smooth conjugate addition onto en-1,4-dione derived from isatin and acetophenone, in the presence of a catalytic amount of molecular iodine in acetonitrile under mild conditions to afford a novel class of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-one derivatives in good yields with high degree of 1,4-selectivity. Some of these compounds are found to exhibit modest antibacterial and antifungal properties.
Assuntos
Antibacterianos/química , Antifúngicos/química , Indóis/química , Iodo/química , Antibacterianos/farmacologia , Antifúngicos/farmacologia , Catálise , Iodo/farmacologia , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Testes de Sensibilidade Microbiana , Espectrofotometria InfravermelhoRESUMO
Three-component coupling of aldehyde, indole and kojic acid has been achieved using a catalytic amount of InCl(3) under solvent free conditions to produce a novel series of 2-substituted aryl(indolyl)kojic acid derivatives in good yields and with high selectivity. These compounds are found to exhibit potent antifungal properties.