RESUMO
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Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Sialometaplasia Necrosante/diagnóstico , Diagnóstico Diferencial , Neoplasias das Glândulas Salivares/diagnóstico , Isquemia/complicações , Granuloma Letal da Linha Média/diagnósticoRESUMO
La carga inmediata en la mandíbula se ha incorporado a la prácticaclínica en primer lugar y, por las características del hueso, se realiza deforma protocolizada. Sin embargo, en el maxilar superior no hay evidenciacientífica para realizarlo de forma cotidiana. Las razones son debidas aque el maxilar superior, en general, alberga una masa ósea de menor densidad.Por otro lado, en el maxilar superior pueden coexistir diferentes densidadesóseas (según la clasificación de Misch) en el mismo individuo. Además,por las características anatómicas del maxilar superior (reabsorciónlabiopalatina) el alineamiento axial es asumible pero, sin embargo, el paralelismode los implantes es difícil.16,17El objetivo del presente trabajo es analizar la información científica de laque disponemos para confirmar si es posible la carga inmediata sobre elmaxilar superior. Para ello estudiaremos varios aspectos de la carga inmediataen el maxilar superior: Sobredentaduras Prótesis fija completa Prótesis parcial fija Prótesis unitaria fija Requerimientos protésicos Contraindicaciones(AU)
Immediate loading in the mandible has been introducedinto clinical practice taking first place and, and because of thecharacteristics of the bone, this is carried out following a protocol.However, in the maxilla there is no scientific evidence for routinelycarrying this out. This is because the maxilla, in general, has a lowerbone mass density. Moreover, in the maxilla various densities maycoexist (according to Mischs classification) in the same individual.In addition, given the anatomic characteristics of the maxilla (lipand palate resorption), axial alignment can be carried out, butimplant parallelism is difficult.16,17The aim of this paper is to analyze the scientific information thatwe have at our disposal in order to confirm whether immediateloading in the maxilla is possible. For this we will study variousaspects of immediate loading in the maxilla: Overdentures Fixed complete prostheses Fixed partial prostheses Fixed single tooth prostheses Prosthetic requirements Contraindications(AU)
Assuntos
Humanos , Prótese Total Imediata , Maxila/cirurgia , Densidade Óssea , Prótese Total Superior , Prótese Parcial ImediataRESUMO
The present study explores the potential utility of peripheral versus central administration of glucagon-like peptide-1 (GLP-1) receptor agonists in the regulation of feeding behavior in Wistar and Zucker obese rats. Acute central (intracerebroventricular [i.c.v.]) and peripheral (subcutaneous [s.c.]) administration of both GLP-1 (7-36) amide and exendin-4 resulted in a reduction in food intake for at least 4 hours, exendin-4 being much more potent than GLP-1 (7-36) amide, especially after peripheral administration. Both Zucker obese rats (fa/fa) and their lean littermates (Fa/-) responded to acute central and peripheral administration of exendin-4. Moreover, in situ hybridization revealed specific labeling for the mRNA for GLP-1 receptors in several brain areas of both the obese and lean rats. The presence of this receptor was also detected by affinity cross-linking assays. Long-term s.c. administration of exendin-4 (1 single injection per day, 1 hour prior to the onset of the dark phase of the cycle) decreased daily food intake and practically blocked weight gain in obese rats. In contrast to previous studies, these findings show that peripheral (s.c.) administration of both GLP-1 receptor agonists also induces satiety and weight loss in rats, and suggest the potential usefulness of exendin-4 as a therapeutic tool for the treatment of diabetes and/or obesity.
