[Effect of fenibut on the nocturnal sleep of patients with the alcoholic abstinence syndrome]. / Vliianie fenibuta na nochnoi son bol'nykh s alkogol'nym abstinentnym sindromom.

The authors studied the effect of the tranquilizer phenibut on sleep disturbances in alcoholics at the initial period following alcohol withdrawal. Sleep was registered polygraphically during 2 nights in 12 patients taking the drug and in 10 control patients. The drug did not affect the latent period of falling asleep, increasing, however, the duration of two major phases of sleep and reducing the duration of the drowsiness stage. There was no marked influence on the subjective assessment of sleep.

[Changes in the wave composition of evoked potentials during treatment of endogenous depression]. / Izmenenie volnovogo sostava vyzvannykh potentsialov pri lechenii éndogennoi depressii.

Evoked potentials (EPs) were studied in patients with endogenic depression prior to and during the therapy. It was found that a reduction in the maximum amplitude of EPs reflecting the initial severity of depression could not serve as an indicator of its time-course in the treatment by tricyclic antidepressants. In contrast, the newly identified electrophysiological sign of endogenic depression, a number of EP waves, shifted toward normalization in the process of the treatment parallelled by a decrease in the severity of the depressive syndrome.

[Effect of phenazepam on the nocturnal sleep of patients with the alcoholic abstinence syndrome]. / Vliianie fenazepama na nochnoi son bol'nykh s alkogol'nym abstinentnym sindromom.

The authors studied the effect of phenazepam, a benzodiazepine derivative, on sleep disorders in alcoholic patients at the first period following alcohol intake discontinuation. Polygraphic registration of the sleep pattern was performed for two nights in 18 patients, receiving the drug and in ten patients of the control group. The drug use was associated with the following events: the latent period of falling asleep diminished, the total duration of sleep increased, the duration of consciousness "inside the sleep" decreased. As a result of the second stage recovery, the duration of the phase of slow sleep enhanced with no evidence of delta-sleep recovery. The duration of the fast sleep phase increased. The patients showed a marked improvement of sleep quality.

[Night sleep in patients with the alcohol abstinence syndrome against a background of detoxification therapy]. / Nochnoi son bol'nykh s alkogol'nym abstinentnym sindromom na fone dezintoksikatsionnoi terapii.

Polygraphic records of night sleep taken in 10 alcoholics for three days after the cessation of the alcohol intake showed the following disorders: a disturbance of the sleep cyclic organization, a sleep fragmentation, a considerable prolongation of the drowsiness (stage I), a sharp reduction of the delta-sleep stages. One to two weeks after the abstinence onset stage I was still too long, and the delta-sleep stage remained shorter than normal, despite a clinical improvement and cessation of complaints.

[Effect of moditen-depot therapy on the duration and quality of remissions in schizophrenia patients]. / Vliianie terapii moditenom-depo na dlitel'nost' i kachestvo remissii u bol'nykh schizofreniei.

The authors studied the effectiveness of out-patient treatment by Moditen-Deppt of 128 schizophrenic patients. A comparison of the previous remissions appearing during usual pharmacotherapy and remissions seen during Moditen-Depot treatment depicted statistically significant differences, indicating a distinct prevention of exacerbations due to this preparation, an increase in the duration and improved quality of remissions. Such improved remissions were expressed in lesser severity, in a decrease of psychopathological disturbances, changes qualified as a "mollification of a defect" and an improvement of some socio-clinical indices.