Ultra-high-resolution photon-counting detector computed tomography of the lungs: Phantom and clinical assessment of radiation dose and image quality.

PURPOSE: Photon-counting-detector computed tomography (PCD-CT) offers enhanced noise reduction, spatial resolution, and image quality in comparison to energy-integrated-detectors CT (EID-CT). These hypothesized improvements were compared using PCD-CT ultra-high (UHR) and standard-resolution (SR) scan-modes. METHODS: Phantom scans were obtained with both EID-CT and PCD-CT (UHR, SR) on an adult body-phantom. Radiation dose was measured and noise levels were compared at a minimum achievable slice thickness of 0.5 mm for EID-CT, 0.2 mm for PCD-CT-UHR and 0.4 mm for PCD-CT-SR. Signal-to-noise ratios (SNR) and contrast-to-noise ratios (CNR) were calculated for five tissue densities. Additionally, data from 25 patients who had PCD-CT of chest were reconstructed at 1 mm and 0.2 mm (UHR) slice-thickness and compared quantitatively (SNR) and qualitatively (noise, quality, sharpness, bone details). RESULTS: Phantom PCD-CT-UHR and PCD-CT-SR scans had similar measured radiation dose (16.0mGy vs 15.8 mGy). Phantom PCD-CT-SR (0.4 mm) had lower noise level in comparison to EID-CT (0.5 mm) (9.0HU vs 9.6HU). PCD-CT-UHR (0.2 mm) had slightly higher noise level (11.1HU). Phantom PCD-CT-SR (0.4 mm) had higher SNR in comparison to EID-CT (0.5 mm) while achieving higher resolution (Bone 115 vs 96, Acrylic 14 vs 14, Polyethylene 11 vs 10). SNR was slightly lower across all densities for PCD-CT UHR (0.2 mm). Interestingly, CNR was highest in the 0.2 mm PCD-CT group; PCD-CT CNR was 2.45 and 2.88 times the CNR for 0.5 mm EID-CT for acrylic and poly densities. Clinical comparison of SNR showed predictably higher SNR for 1 mm (30.3 ± 10.7 vs 14.2 ± 7, p = 0.02). Median subjective ratings were higher for 0.2 mm UHR vs 1 mm PCD-CT for nodule contour (4.6 ± 0.3 vs 3.6 ± 0.1, p = 0.02), bone detail (5 ± 0 vs 4 ± 0.1, p = 0.001), image quality (5 ± 0.1 vs 4.6 ± 0.4, p = 0.001), and sharpness (5 ± 0.1 vs 4 ± 0.2). CONCLUSION: Both UHR and SR PCD-CT result in similar radiation dose levels. PCD-CT can achieve higher resolution with lower noise level in comparison to EID-CT.

A review of dental cone-beam CT dose conversion coefficients.

OBJECTIVE: The purpose of this study was to review the literature to examine the usage and magnitude of effective dose conversion factors (DCE) for dental cone beam CT (CBCT) scanners. METHODS: A PubMed literature search for publications relating to radiation dosimetry in dental radiography was performed. Papers were included if they reported DCE, or reported ICRP 103 effective dose and dose-area product. 71 papers relating to dental CBCT dosimetry were found, of which eight reported effective dose conversion factors or provided enough information to calculate dose conversion factors. Scanner model, effective dose, dose-area product, tube voltage, field of view size and DCE were extracted from the papers for analysis. RESULTS: DCE values ranged from 0.035 to 0.31 µSv/mGy-cm2 with a mean of 0.129 µSv/mGy-cm2 (SD = 0.056). When categorized into small (<100 cm2), medium (100-225 cm2) and large (>225 cm2) fields of view (FOV), linear fits to the effective dose and dose-area product yielded slopes of 0.129, 0.111 and 0.074 µSv/mGy-cm2 for small, medium and large FOVs respectively. CONCLUSION: The range of reported DCE values and spread with respect to field of view category suggests that DCE values that depend on FOV would provide more accurate effective dose estimates. Tube voltage was found to be a smaller factor in determining DCE. Reasonable values for DCE taking into account FOV size were obtained. There is considerable room for more work to be done to examine the behaviour of DCE with changes to patient age and dental CBCT imaging parameters.

Review of Kerma-Area Product and total energy incident on patients in radiography, mammography and CT.

This study estimated the energy incident on patients in radiography, mammography and CT using data related to X-ray beam quantity and quality. The total X-ray beam quantity is the average Air Kerma multiplied by the X-ray beam area and expressed as the Kerma-Area Product (Gy cm(-2)). The X-ray beam quality primarily depends on the target material (and anode angle), X-ray voltage (and ripple) as well as X-ray beam filtration. For any X-ray spectra, dividing total energy (fluence × mean energy) by the X-ray beam Kerma-Area Product yields the energy per Kerma-Area Product value (ε/KAP). Published data on X-ray spectra characteristics and energy fluence per Air Kerma conversion factors were used to determine ε/KAP factors. In radiography, ε/KAP increased from 6 mJ Gy(-1) cm(-2) at the lowest X-ray tube voltage (50 kV) to 25 mJ Gy(-1) cm(-2) at the highest X-ray tube voltage (140 kV). ε/KAP values ranged between 1 and 5 mJ Gy(-1) cm(-2) in mammography and between 24 and 42 mJ Gy(-1) cm(-2) in CT. Changes in waveform ripple resulted in variations in ε/KAP of up to 15 %, similar to the effect of changes resulting in the choice of anode angle. For monoenergetic X-ray photons, there was a sigmoidal-type increase in ε/KAP from 2 mJ Gy(-1) cm(-2) at 20 keV to 42 mJ Gy(-1) cm(-2) at 80 keV. However, between 80 and 150 keV, the ε/KAP shows variations with changing photon energy of <10 %. Taking the average spectrum energy to consist of monoenergetic X rays generally overestimates the true value of ε/KAP. This study illustrated that the energy incident on a patient in any area of radiological imaging can be estimated from the total X-ray beam intensity (KAP) when X-ray beam quality is taken into account. Energy incident on the patient can be used to estimate the energy absorbed by the patient and the corresponding patient effective dose.

Does administering iodine in radiological procedures increase patient doses?

PURPOSE: The authors investigated the changes in the pattern of energy deposition in tissue equivalent phantoms following the introduction of iodinated contrast media. METHODS: The phantom consisted of a small "contrast sphere," filled with water or iodinated contrast, located at the center of a 28 cm diameter water sphere. Monte Carlo simulations were performed using mcnp5 codes, validated by simulating irradiations with analytical solutions. Monoenergetic x-rays ranging from 35 to 150 keV were used to simulate exposures to spheres containing contrast agent with iodine concentrations ranging from 1 to 100 mg/ml. Relative values of energy imparted to the contrast sphere, as well as to the whole phantom, were calculated. Changes in patterns of energy deposition around the contrast sphere were also investigated. RESULTS: Small contrast spheres can increase local absorbed dose by a factor of 13, but the corresponding increase in total energy absorbed was negligible (<1%). The highest localized dose increases were found to occur at incident photon energies of about 60 keV. For a concentration of about 10 mg/ml, typical of clinical practice, localized absorbed doses were generally increased by about a factor of two. At this concentration of 10 mg/ml, the maximum increase in total energy deposition in the phantom was only 6%. These simulations demonstrated that increases in contrast sphere doses were offset by corresponding dose reductions at distal and posterior locations. CONCLUSIONS: Adding iodine can result in values of localized absorbed dose increasing by more than an order of magnitude, but the total energy deposition is generally very modest (i.e., <10%). Their data show that adding iodine primarily changes the pattern of energy deposition in the irradiated region, rather than increasing patient doses per se.

Improved nuclear medicine uniformity assessment with noise texture analysis.

UNLABELLED: Because γ cameras are generally susceptible to environmental conditions and system vulnerabilities, they require routine evaluation of uniformity performance. The metrics for such evaluations are commonly pixel value-based. Although these metrics are typically successful at identifying regional nonuniformities, they often do not adequately reflect subtle periodic structures; therefore, additional visual inspections are required. The goal of this project was to develop, test, and validate a new uniformity analysis metric capable of accurately identifying structures and patterns present in nuclear medicine flood-field uniformity images. METHODS: A new uniformity assessment metric, termed the structured noise index (SNI), was based on the 2-dimensional noise power spectrum (NPS). The contribution of quantum noise was subtracted from the NPS of a flood-field uniformity image, resulting in an NPS representing image artifacts. A visual response filter function was then applied to both the original NPS and the artifact NPS. A single quantitative score was calculated on the basis of the magnitude of the artifact. To verify the validity of the SNI, an observer study was performed with 5 expert nuclear medicine physicists. The correlation between the SNI and the visual score was assessed with Spearman rank correlation analysis. The SNI was also compared with pixel value-based assessment metrics modeled on the National Electrical Manufacturers Association standard for integral uniformity in both the useful field of view (UFOV) and the central field of view (CFOV). RESULTS: The SNI outperformed the pixel value-based metrics in terms of its correlation with the visual score (ρ values for the SNI, integral UFOV, and integral CFOV were 0.86, 0.59, and 0.58, respectively). The SNI had 100% sensitivity for identifying both structured and nonstructured nonuniformities; for the integral UFOV and CFOV metrics, the sensitivities were only 62% and 54%, respectively. The overall positive predictive value of the SNI was 87%; for the integral UFOV and CFOV metrics, the positive predictive values were only 67% and 50%, respectively. CONCLUSION: The SNI accurately identified both structured and nonstructured flood-field nonuniformities and correlated closely with expert visual assessment. Compared with traditional pixel value-based analysis, the SNI showed superior performance in terms of its correlation with visual perception. The SNI method is effective for detecting and quantifying visually apparent nonuniformities and may reduce the need for more subjective visual analyses.

A web based Foundations of Radiological Physics for diagnostic radiology residents.

UNLABELLED: RATIONALE AND OBJECTS: We describe a new web-based physics course for radiology residents preparing for the Exam of the Future (EOF). MATERIALS AND METHODS: A course was developed with a total of 12 web-based modules. Six modules were focused on "imaging" and six on "radiation." A module was subdivided into nine short "nuggets." Traditional lectures were replaced by modules using prerecorded lectures (Tegrity) to a secure website (WebCT). Each module was accompanied by three quizzes, each consisting of ten questions designed to reinforce covered materials. All online modules were accompanied by a noon conference that employed an Audience Response System (Turning Point). Seventeen first-year residents over 2 consecutive years beginning in July 2010 took this new course, and participated in an anonymous online follow-up survey (Survey Monkey). RESULTS: The recorded 12 modules had an overall average duration of 72 ± 19 minutes. Ten of 17 residents expressed a preference of 15 minutes for nugget duration. Highest personal assessment scores of each resident's understanding were obtained in human radiation risks and radiation protection. Residents considered supplemental noon conferences to be important for learning radiological physics. Satisfaction level was largely positive, with five residents highly satisfied, nine residents somewhat satisfied, two residents neutral, and only one resident somewhat dissatisfied. CONCLUSIONS: Our Foundations of Radiological Physics course was well received and served as the springboard for mastering x-ray-based imaging modalities of radiography, mammography, fluoroscopy, interventional radiology, and computed tomography.

Effective radiation dose in computed tomographic angiography of the chest and diagnostic cardiac catheterization in pediatric patients.

Computed tomographic angiography (CTA) and cardiac catheterization are useful adjuncts to echocardiography for delineating cardiovascular anatomy in pediatric patients. These studies require ionizing radiation, and it is paramount to understand the amount of radiation pediatric patients receive when these tests are performed. Modern dosimetry methods facilitate the conversion of radiation doses of varying units into an effective radiation dose. To compare the effective radiation dose between nongated CTA of the chest and diagnostic cardiac catheterization in pediatric patients. This is a retrospective cohort study of patients of patients who underwent either nongated CTA of the chest or diagnostic cardiac catheterization between July 2009 and April 2010. Fifty patients were included in each group as consecutive samples at a single tertiary care center. An effective radiation dose (mSv) was formulated using conversion factors for each group. The median effective dose (ED) for the CTA group was 0.74 mSv compared with 10.8 mSv for the catheterization group (p < 0.0001). The median ED for children <1 year of age in the CTA group was 0.76 mSv compared with 13.4 mSv for the catheterization group (p < 0.0001). Nongated CTA of the chest exposes children to 15 times less radiation than diagnostic cardiac catheterization. Unless hemodynamic data are necessary, CTA of the chest should be considered in lieu of diagnostic cardiac catheterization in patients with known or presumed cardiac disease who need additional imaging beyond echocardiography.

Radiation-related cancer risks in a clinical patient population undergoing cardiac CT.

OBJECTIVE: The purpose of our study was to estimate cancer induction risk and generate risk conversion factors in cardiac CT angiography. MATERIALS AND METHODS: Under an institutional review board waiver and in compliance with HIPAA, we collected characteristics for a consecutive cohort of 100 patients (60 men and 40 women; mean age, 59 ± 11 years) who had previously undergone ECG-gated cardiac CT angiography on a 64-slice CT scanner. The volume CT Dose Index (CTDI(vol)) and dose-length product (DLP) were recorded and used with the ImPACT CT Patient Dosimetry Calculator to compute organ and effective doses in a standard 70 kg phantom. Patient-specific organ and effective doses were obtained by applying a weight-based correction factor. Radiation doses to radiosensitive organs were converted to risks using age- and sex-specific data published in BEIR VII. RESULTS: Median values were 62 mGy for CTDI(vol), 1,084 mGy-cm for DLP, and 17 cm for scan length. Effective doses ranged from 20 mSv (10th percentile) to 31 mSv (90th percentile). Median cancer induction risks in sensitive organs for men and women were 0.065% and 0.17%, respectively. For men and women, the range of risks was about a factor of 2. In men and women, about three quarters of the cancer risk was from lung cancer. Inclusion of the remaining less sensitive organs exposed during cardiac CT angiography examinations would likely increase the cancer induction risk by ∼20%. CONCLUSION: The average cancer induction risk in sensitive organs from cardiac CT angiography for our patient cohort was 0.13%, with a female to male cancer induction risk ratio of 2.6.

Embryo dose estimates in body CT.

OBJECTIVE: The purpose of this article is to develop a method for estimating embryo doses in CT. MATERIALS AND METHODS: Absorbed doses to the uterus (embryo) of a 70-kg woman were estimated using the ImPACT CT Patient Dosimetry Calculator. For a particular CT scan length, relative uterus doses and normalized plateau uterus doses were determined for a range of commercial CT scanners. Patient size characteristics were obtained from cross-sectional axial images of 100 consecutive patients (healthy women undergoing unenhanced pelvic CT examinations). For each patient, the diameter of a water cylinder with the same mass as the patient's pelvis was computed. Relative dose values were generated for cylinder diameters ranging from 16 to 36 cm at x-ray tube voltages between 80 and 140 kV. RESULTS: Values of relative uterus dose increased monotonically with increasing scan length, independently of scanner model, and reached a plateau for scan lengths greater than approximately 50 cm. The average normalized plateau uterus dose for all scanners was approximately 1.4 and showed interscanner differences of less than 10% for modern scanners operated at 120 kV. Normalized plateau doses show little dependence on the x-ray tube voltage used to perform the CT examination. Our results show that the uterus dose estimate in an abdominal or pelvis CT examination performed on a 70-kg patient is about 40% higher than the reported value of the volume CT dose index (CTDI(vol)). The pelvis of a 70-kg patient may be modeled as a water cylinder with a diameter of 28 cm and has an average anteroposterior dimension of 22 cm. For constant CT technique factors, embryo dose estimates for a 45-kg patient would be approximately 18% higher than those for a 70-kg patient, whereas the corresponding dose estimates in a 120-kg patient would be approximately 37% lower. CONCLUSION: Embryo doses can be estimated using relative uterus doses, normalized plateau uterus doses, and CTDI(vol) data with correction factors for patient size.

An exposure indicator for digital radiography: AAPM Task Group 116 (executive summary).

Digital radiographic imaging systems, such as those using photostimulable storage phosphor, amorphous selenium, amorphous silicon, CCD, and MOSFET technology, can produce adequate image quality over a much broader range of exposure levels than that of screen/film imaging systems. In screen/film imaging, the final image brightness and contrast are indicative of over- and underexposure. In digital imaging, brightness and contrast are often determined entirely by digital postprocessing of the acquired image data. Overexposure and underexposures are not readily recognizable. As a result, patient dose has a tendency to gradually increase over time after a department converts from screen/film-based imaging to digital radiographic imaging. The purpose of this report is to recommend a standard indicator which reflects the radiation exposure that is incident on a detector after every exposure event and that reflects the noise levels present in the image data. The intent is to facilitate the production of consistent, high quality digital radiographic images at acceptable patient doses. This should be based not on image optical density or brightness but on feedback regarding the detector exposure provided and actively monitored by the imaging system. A standard beam calibration condition is recommended that is based on RQA5 but uses filtration materials that are commonly available and simple to use. Recommendations on clinical implementation of the indices to control image quality and patient dose are derived from historical tolerance limits and presented as guidelines.

Comparison of medium- and high-energy collimators for 131I-tositumomab dosimetry.

UNLABELLED: Residence time measurements obtained by serial whole-body conjugate-view imaging are commonly used in patient-specific dosimetry for radioimmunotherapy applications. In order to determine the effect of collimator selection on residence time measurements for (131)I, the accuracies of (131)I half-life measurements obtained with multiple gamma-camera and collimator combinations were investigated. METHODS: Serial anterior and posterior whole-body images were acquired over a period of 15 d with 4 different gamma-cameras and medium- or high-energy collimators. Background-corrected geometric mean counts from the images were fitted to a monoexponential curve to determine the half-life of (131)I obtained with the different gamma-camera and collimator combinations. RESULTS: An average half-life of 8.15 d (SD, 0.07 d) was obtained with all gamma-camera and collimator combinations. A half-life of 8.12 d (SD, 0.11 d) was obtained with the high-energy collimators, and a half-life of 8.18 d (SD, 0.04 d) was obtained with the medium-energy collimators. These values are all very close to the (131)I physical half-life of 8.02 d and were not found to be statistically significantly different (P = 0.44). Similar results were obtained for the half-life obtained with single-head gamma-camera configurations (mean half-life, 8.15 d; SD, 0.12 d). The therapeutic (131)I-tositumomab dose resulting from the differences in the measured half-life ranged from 2.58 to 2.6 GBq (69.8-70.4 mCi). CONCLUSION: There is no significant difference in (131)I half-life and residence time measurements obtained with medium- or high-energy collimators in dual-head or single-head imaging configurations.

Evaluation of a flat panel digital radiographic system for low-dose portable imaging of neonates.

The purpose of this study was to evaluate the clinical utility of an investigational flat-panel digital radiography system for low-dose portable neonatal imaging. Thirty image-pairs from neonatal intensive care unit patients were acquired with a commercial Computed Radiography system (Agfa, ADC 70), and with the investigational system (Varian, Paxscan 2520) at one-quarter of the exposure. The images were evaluated for conspicuity and localization of the endings of ancillary catheters and tubes in two observer performance experiments with three pediatric radiologists and three neonatologists serving as observers. The results indicated no statistically significant difference in diagnostic quality between the images from the investigational system and from CR. Given the investigational system's superior resolution and noise characteristics, observer results suggest that the high detective quantum efficiency of flat-panel digital radiography systems can be utilized to decrease the radiation dose/exposure to neonatal patients, although post-processing of the images remains to be optimized. The rapid availability of flat-panel images in portable imaging was found to be an added advantage for timely clinical decision-making.

Dual-phase 99mTc-sestamibi imaging: its utility in parathyroid hyperplasia and use of immediate/delayed image ratios to improve diagnosis of hyperparathyroidism.

OBJECTIVE: Dual-phase (99m)Tc-sestamibi (methoxyisobutylisonitrile [MIBI]) imaging is the technique of choice for hyperparathyroidism (HPT), especially for localizing parathyroid adenomas. Prior studies have shown its utility for detecting hyperplasia is equivocal, but we believe this is not true. We attempted to quantitate the region-of-interest counts per pixel between immediate images and delayed images (I/D ratio) and use this ratio to distinguish normal parathyroid versus hyperplasia versus adenoma. METHOD: Anterior pinhole and upper thorax images with a low-energy, high-resolution collimator at 20 min and 2 h after (99m)Tc-MIBI injection were obtained on 54 subjects. The results were analyzed retrospectively as hyperplasia, adenoma, or normal parathyroid by the persistence of activity in 2 or more foci, a solitary focus, or no activity on the delayed images. These interpretations were compared with pathology when available. I/D ratios were computed for all scans, and mean ratios were calculated for each type of pathology (normal parathyroid, hyperplasia, and adenoma). The resulting ratios were analyzed with a t test to determine significant differences between the ratios. RESULTS: Sensitivity and specificity were 96% and 88%, respectively, for parathyroid hyperplasia. Mean I/D ratios were 2.26 +/- 0.68, 2.80 +/- 0.95, and 3.10 +/- 0.77 for subjects with hyperplasia, adenoma, and normal parathyroid, respectively (hyperplasia vs. normal, P = 0.020; adenoma vs. normal, P = 0.381; hyperplasia vs. adenoma, P = 0.033). CONCLUSION: Dual-phase (99m)Tc-MIBI imaging is more sensitive and specific for parathyroid hyperplasia than reported previously, supporting its use to localize hyperplastic glands preoperatively and to help guide resection. A thyroid ratio between immediate and delayed images will aid in distinguishing hyperplasia from normal parathyroid in uncertain cases.