Assuntos
Cromo/análise , Diabetes Mellitus Experimental/dietoterapia , Hordeum/química , Animais , Humanos , RatosRESUMO
A study was conducted to explore the effects of different sources of dietary carbohydrate on the altered metabolism of basement membrane proteins (type IV collagen and laminin) that occurs in the streptozotocin-diabetic rat. The substitution of barley for sucrose reduced the elevated plasma concentration of 7-S collagen and of laminin P2, peptide fragments that retain antigenicity of the parent proteins. Similar effects were noted in the liver and kidney content of these peptides. It is suggested that the beneficial property of barley is due to its high content of chromium, as has been demonstrated in the study of glucose metabolism.
Assuntos
Membrana Basal/metabolismo , Glicemia/metabolismo , Diabetes Mellitus Experimental/metabolismo , Carboidratos da Dieta/farmacologia , Hordeum , Animais , Cromo , Colágeno/metabolismo , Carboidratos da Dieta/administração & dosagem , Laminina/metabolismo , Masculino , Ratos , Ratos Sprague-Dawley , Sacarose/administração & dosagemRESUMO
The alleged beneficial properties of barley in the treatment of diabetes were investigated. Rates of growth, water and food (digestible energy) intakes, and blood glucose concentrations were measured before and after the induction of diabetes in rats fed diets containing either barley or wheat. No differences were found in healthy animals, but in the diabetic state the blood glucose concentration, water consumption and weight loss was significantly lower in the rats fed barley. It is suggested that a factor other than the fibre content of the cereals may be responsible for the difference in response.
Assuntos
Diabetes Mellitus Experimental/dietoterapia , Hordeum , Plantas Medicinais , Animais , Glicemia/metabolismo , Diabetes Mellitus Experimental/sangue , Diabetes Mellitus Experimental/fisiopatologia , Comportamento de Ingestão de Líquido , Masculino , Ratos , Ratos Endogâmicos , TriticumRESUMO
In adult diabetic rats, a diet containing barley had a modulating effect on the symptoms of diabetes (blood glucose concentration and water consumption) when compared with a starch or sucrose-based diet. It was postulated that the beneficial effect of barley might be explained by its very high content of chromium (5.69 micrograms/g). Supplementation of the sucrose-based diet with an amount of trivalent inorganic chromium calculated to be equivalent to the available chromium in the barley-based diet abolished the differences in response to the diabetic state.