RESUMO
BACKGROUND AND OBJECTIVE: The fibrinogen receptor the human platelet antigen (HPA1 and HPA3) have an essential role in Atherothrombosis. This study aimed to detect the association of αIIbß3 polymorphism with ischemic stroke in Sudanese patients and its association with the common risk factors. METHODOLOGY: This is a case-control study. Fifty atherosclerotic with ischemic stroke Sudanese patients were included in present study and were compared to apparently 50 healthy Sudanese subjects at the same ages. The ages of both groups were >18 years. About 5 mL of venous blood sample was taken from each patient and control. The laboratory analyses were done for HbA1c, lipid profile and DNA genotyping by polymerase chain reaction (PCR) followed by FokI and ScrFI digestion. RESULTS: The result showed that, the risk factors (TRI.G, HDL, HbA1C, and body mass index were associated with the increased risk of ischemic stroke). None of the cholesterol levels and LDL increased the risk of stroke. The risk of ischemic stroke was higher with B/B genotype in HPA3 (p-value 0.009) and A/B genotype in HPA1 (p-value 0.041) and HPA1 (p-value 0.041). CONCLUSION: The αIIbß3 polymorphism were with ischemic stroke in Sudanese patients.
Assuntos
Isquemia Encefálica/genética , Predisposição Genética para Doença/genética , Complexo Glicoproteico GPIIb-IIIa de Plaquetas/genética , Polimorfismo de Nucleotídeo Único/genética , Receptores de Fibrinogênio/genética , Acidente Vascular Cerebral/genética , Adolescente , Estudos de Casos e Controles , LDL-Colesterol/genética , Feminino , Genótipo , Humanos , Masculino , Fatores de RiscoRESUMO
BACKGROUND AND OBJECTIVE: Glycoprotein IIIa and GPIIb constitutes are the fibrinogen receptor (integrin αIIbß3). This glycoprotein has a fundamental role in atherothrombosis. This study aimed to detect the association of αIIbß3 polymorphisms with atherosclerotic coronary heart disease in Sudanese patients and the association between the risk factors and platelet integrin αIIbß3 polymorphisms. MATERIALS AND METHODS: This is a case-control hospital-based study contain 50 atherosclerotic patients (>18 years) with coronary heart disease that admitted to Khartoum hospital and were compared to apparently 50 healthy Sudanese subjects at the same ages. About 5 mL of venous blood sample was collected from each patient and control. The laboratory analyses were done for HbA1c, lipid profile and for DNA genotyping. RESULTS: LDL, HDL, HbA1c and body mass index have shown highly significant influence on patients. No significant differences were observed for triglycerides and total cholesterol levels. The risks of coronary heart disease were higher with A/B genotype in HPA3, but no association detected with coronary heart disease patients in HPA1 polymorphism. CONCLUSION: In conclusion, HPA3 polymorphism was associated with atherosclerotic in Sudanese patients, while HPA1 polymorphism has not.
