Characterizing neck and spinal response in booster seated reclined children in frontal impacts.

OBJECTIVE: Belt-positioning booster seats (BPB) and pre-pretensioner (PPT) belts may be effective in preventing injuries from submarining and head excursion in reclined children. It is unknown if injuries at the neck and spine could still occur. This study's goal is to characterize neck and spine responses in reclined children with and without the BPB and the PPT. METHODS: Eleven frontal impact sled tests were performed (56 kph) with the Large Omnidirectional Child (LODC) dummy on a production vehicle seat. A 3-point simulated seat-integrated-belt was used with a load-limiter (∼4.5 kN). Testing was conducted with and without the BPB with the seatback at ∼25°, ∼45° and repeated once. One test was conducted at ∼60° with the BPB. 100 mm of belt-slack was removed to simulate PPT in two 45° BPB tests and the BPB 60° test. The LODC peak thoracic spine accelerations and angular rotations, and peak neck and lumbar force/moment loads were compared between conditions. RESULTS: Neck shear forces were the highest in the 60° BPB & PPT (-1.9 kN) and 45° noBPB (-1.3 kN) than all other BPB conditions (-0.5 to -0.8 kN). The highest peak neck moments were found in the 45° noBPB (-40.5 N-m), and in the 60° BPB & PPT (-34.2 N-m) conditions compared to all others (-20.8 to -27.9 N-m.). The 60° BPB and PPT condition demonstrated thoracic forward rotation similar to the 25° noBPB condition (25° noBPB -24.8 to -35.0 deg, 60° BPB&PPT -27.5 to -43.2 deg.). Thoracic spine peak resultant accelerations (T1, T6, T12) were higher in the 25° and 45° noBPB conditions (53 g to 71 g) and in the 60° BPB & PPT (T6: 61.8 g) compared to all other BPB conditions (48.4 g to 53.1 g). The lumbar peak shear forces and moments were the highest in the 45° noBPB (4.9 kN, -296 N-m) and the 60° BPB & PPT condition (1.7 kN, -146 N-m). CONCLUSION: These findings show similarities in neck, spine, and lumbar responses between the 60° reclined condition with BPB and PPT and the 25° and 45° conditions without the same countermeasures. This study highlights the need for future restraint developments to protect moderate and severe reclined BPB-seated child occupants.

The effect of a startle-based warning, age, sex, and secondary task on takeover actions in critical autonomous driving scenarios.

Introduction: In highly autonomous driving scenarios, it is critical to identify strategies to accelerate reaction times since drivers may take too long to take over control of the vehicle. Previous studies reported that an Acoustic Startling Pre-Stimulus (ASPS, i.e., a loud warning preceding an action) accelerated reaction times in simple ankle flexion exercises. Methods: In this study, we examined if an ASPS warning leads to shorter takeover reaction times in a sled-simulated evasive swerving maneuver. Twenty-eight participants (seven male adults, seven male teenagers, seven female adults, and seven female teenagers) were instructed to align a marker on the steering wheel with a marker on a lateral post as fast as they could as soon as the lateral sled perturbation (0.75 g) started. Four conditions were examined: with and without an ASPS (105 dB, played 250 ms before sled perturbation for 40 ms), and with and without a secondary task (i.e., texting). A catch trial (ASPS only) was used to minimize anticipation. Human kinematics were captured with an 8-camera 3D motion capture system. Results: Results showed that the drivers' hands lifted towards the steering wheel more quickly with the ASPS (169 ± 55 ms) than without (194 ± 46 ms; p = 0.01), and that adult drivers touched the steering wheel quicker with the ASPS (435 ± 54 ms) than without (470 ± 33 ms; p = 0.01). Similar findings were not observed for the teen drivers. Additionally, female drivers were found to lift their hands towards the steering wheel faster than male drivers (166 ± 58 ms vs. 199 ± 36 ms; p = 0.009). Discussion: Our findings suggest that the ASPS may be beneficial to accelerate driver reaction times during the initiation of a correction maneuver, and that autonomous vehicle warnings may need to be tailored to the age and sex of the driver.

Head excursions of rearward-facing child restraint systems in rear impacts.

OBJECTIVE: The aim of the current study was to quantify the head excursions of pediatric anthropomorphic test devices (ATDs) seated in rearward-facing child restraint system (CRS) models during rear impact sled tests and compare to roof heights of vehicles in the current fleet to assess the possibility of head contact against the vehicle roof. METHODS: Head excursions of ATDs seated in rearward-facing CRS models were analyzed from high-speed video data from 14 rear impact sled tests across two different series. Tests were conducted in rigidized vehicle seats from recent model year vehicles. Rearward-facing infant and convertible CRS models were tested with a variety of pediatric ATDs aged 12 months to 6 years in a variety of installation conditions (e.g., lower anchors or seat belt, anti-rotation features, etc). Maximum ATD head excursions in plane of the seatback were compared to previously measured roof heights of 87 different vehicles. RESULTS: The roof heights in all sedan seating positions (n = 58) and SUV/CUV/minivan seating positions (n = 60) were greater than the largest maximum ATD head excursions in plane of the seatback (792 mm). Head contact was possible in two of the pickup trucks which had roof heights of 730 and 775 mm. In all, 98% of vehicle seating positions measured in this study would accommodate all of the maximum ATD head excursions in plane of the seatback without contact. CONCLUSIONS: The risk of head contact against the vehicle interior roof appears low as maximum ATD head excursions in plane of the seatback were typically not great enough to reach the rooflines of the vehicles in the sample. Head contact appears possible in pickup trucks, where the window/roofline is directly behind the head restraint.

COVID 19 Care Call-in Helpline. A Report from India.

A COVID 19 call helpline was established by a noted TV channel along with a group of consultant doctors at the height of the second wave COVID 19 pandemic in India. It helped the general public to understand dos and donts as well as long term implications. We retrospectively analysed the questions asked to get a feel of the misunderstandings and perceptions within the general public. Many quereies related to the vaccination drive.

Interactions between rearward-facing child restraint systems and the front row seatback in frontal impact sled tests.

OBJECTIVE: Some child restraint system (CRS) manufacturers specify a minimum distance between the CRS and the seatback, whereas others require that the CRS may contact the seatback but cannot be "braced"; however, few studies have investigated these interactions. Therefore, the aim was to investigate the interactions between the front row seat and rearward-facing CRS models with and without a support leg during frontal crashes. METHODS: Sled tests using the FMVSS 213 frontal crash pulse were performed with the Q1.5 and Q3 anthropomorphic test devices (ATDs) seated in rearward-facing infant and convertible CRS models, respectively. A front row vehicle seat was in front of the test bench in three track positions: brace, touch and gap. For the touch condition, the front row seat was translated aftward until the seatback contacted the CRS. For the brace condition, the front row seat was translated 20 mm aftward. For the gap condition, the front row seat was translated 50 mm forward. Each condition was tested with and without the support leg of the CRS. RESULTS: The tests with a support leg were associated with significantly (p = 0.007) lower resultant linear head acceleration 3 ms clip compared to the tests without a support leg, but the reduction of head injury criterion 15 ms (HIC15) was not significant (p = 0.057). The Q1.5 ATD in the rearward-facing infant CRS with a support leg had the lowest injury metrics for the touch and gap conditions, whereas the Q3 in the rearward-facing convertible CRS had the lowest head injury metrics for the brace condition. CONCLUSIONS: The use of a support leg provided a clear benefit in terms of reducing head injury metrics for the Q1.5 in the rearward-facing infant CRS, especially for the touch and gap conditions. The rearward-facing convertible CRS in the current study appears to benefit from being braced against the front row seat. However, further tests are required to allow further statistical comparisons and determine if these preliminary findings extend to other rearward-facing CRS models.

Management Guidelines for Infection After ACL Reconstruction: Expert Opinion Statement Based on the Modified Delphi Survey of Indian Arthroscopy Surgeons.

AIM: Infection after anterior cruciate ligament (ACL) reconstruction, though rare, is a potentially devastating complication and the evidence-based recommendation on the various topics in its management is limited. The purpose of this study was to develop recommendations for the prevention and management of infections in ACL reconstruction surgery by performing a structured expert consensus survey using Delphi methodology. MATERIALS AND METHODS: 22 topics of relevance in the prevention and management of infection following ACL reconstruction were chosen from an extensive literature review. 30 panelists were requested to respond to a three-round survey, with feedback, to develop a consensus statement on the topics. RESULTS: Consensus statements could be prepared in eleven out of twenty-two topics including: the graft is retained at the first arthroscopic debridement, the graft is removed when repeated debridement are needed, and revision ACL reconstruction is needed only if the patient develops instability. Concurrence could be obtained in the topics including: longer duration of antibiotics is needed in immunocompromised patients, soaking graft in antibiotic solution reduces infection risk, and knee swelling without warmth does not suggest infection. CONCLUSIONS: A proper skin preparation, a longer course of antibiotics in immunocompromised patients, and soaking the graft in antibiotics reduces the risk of infection. In case of infection, a healthy-looking graft must be retained at the first debridement and if the graft must be removed, revision ACL reconstruction is advised only if the patient develops instability. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s43465-021-00363-z.

Analysis of Kinematic Response of Pediatric Occupants Seated in Naturalistic Positions in Simulated Frontal Small Offset Impacts: With and Without Automatic Emergency Braking.

Naturalistic driving studies have shown that pediatric occupants do not assume ideal seating positions in real-world scenarios. Current vehicle assessment programs and child restraint system (CRS) sled tests, such as FMVSS No. 213, do not account for a wide range of seating postures that are typically observed during real-world trips. Therefore, this study aims to analyze the kinematic and kinetic response of a pediatric human body model in various naturalistic seating positions in booster seats when subjected to a frontal offset impact in a full-vehicle environment, with and without the application of pre-crash automatic emergency braking (AEB). A 6YO (seated on a lowback and highback booster) and a 10YO (seated in no-CRS and on a lowback booster) PIPER pediatric human body model's response was explored in a reference, and two most commonly observed seating postures: forward-leaning and forward-inboard-leaning. The vehicle environment with a side-curtain airbag (SCAB) was subjected to a small offset barrier impact (25% overlap at 40MPH), with and without the application of a pre-crash automatic emergency braking (AEB). 24 conditions were simulated using finite element analysis. Cases with a pre-crash AEB resulted in relatively lower kinematic and kinetic values due to the occupant being in a more flexed position before impact compared to without-AEB cases, coupled with the increased ride-down effect due to AEB. Moreover, different seating postures resulted in substantially different kinematics and kinetics, the injury metrics crossing the injury assessment reference values in some cases. Therefore, to design a passive safety standard test for pediatric occupants, it is important to consider the possible postural changes that may occur.

Pseudarthrosis of the surgical neck of humerus treated by buttressing with a medial cortico-cancellous graft.

BACKGROUND: Pseudarthrosis of surgical neck of humerus is uncommon condition. Different methods of improving the stability of fixation have been described, including impaling the shaft into the head, placing a tension suture through the rotator cuff, or using an intramedullary cortical graft. We report our results of cortico-cancellous strut graft medially to counter the varus force, in conjunction with a fixed-angle implant on the lateral side. MATERIALS AND METHODS: We used this technique in seven cases of pseudarthrosis of surgical neck of the humerus. There were four women and three men, ranging in age from 22 to 65 years. All were treated with a tricortical medial buttress bone graft and fixed-angle fixation device on the lateral side. A locking proximal humerus plate (Synthes) was used in six cases, and a bent reconstruction plate (Synthes) was applied in one case. The one in which reconstruction plate was applied was operated before the advent of locking plates. The limb was immobilized in 30° of abduction over a cushion for 6 weeks, followed by a sling for another 6 weeks. RESULTS: The followup varied from 18 to 96 months. All our cases healed within mean 5.1 months (range 4-6 months). There was one case of avascular necrosis. All cases had useful function of shoulder. CONCLUSION: The medial buttressing by strut graft with external fixation by laterally placed fixed angle plate is successful to achieve fracture union in pseudarthrosis of surgical neck of humerus.

Resveratrol induces Fas signalling-independent apoptosis in THP-1 human monocytic leukaemia cells.

Resveratrol, a natural product present in wine, has recently been shown to inhibit the growth of a number of cancer cell lines in vitro. In the current study, we have demonstrated that resveratrol inhibits the growth of THP-1 human monocytic leukaemia cells in a dose-dependent manner with a median effective dose of 12 microM. It did not induce differentiation of THP-1 cells and had no toxic effect on THP-1 cells that had been induced to differentiate into monocytes/macrophages by phorbol myristate acetate. A significant fraction of resveratrol-treated cells underwent apoptosis as judged by flow cytometric analysis of DNA content, DNA fragmentation and caspase-specific cleavage of poly(ADP-ribosyl) polymerase. Resveratrol treatment had no effect on the expression of Fas receptor or Fas ligand (FasL) in THP-1 cells, nor did it induce clustering of Fas receptors. In addition, THP-1 cells were resistant to activating anti-Fas antibody, and neutralizing anti-Fas and/or anti-FasL antibodies had no protective effect against resveratrol-induced inhibition of THP-1 cell growth. The effect of resveratrol on THP-1 cells was reversible after its removal from the culture medium. These results suggest that (1) resveratrol inhibits the growth of THP-1 cells, at least in part, by inducing apoptosis, (2) resveratrol-induced apoptosis of THP-1 cells is independent of the Fas/FasL signalling pathway and (3) resveratrol does not induce differentation of THP-1 cells and has no toxic effect on differentiated THP-1 cells. Thus, resveratrol may be a potential chemotherapeutic agent for the control of acute monocytic leukaemia.

Angiomyoma of the knee joint: value of magnetic resonance imaging.

A case of angiomyoma as an unusual cause of knee pain is presented and the usefulness of magnetic resonance imaging in such a situation is discussed.

Medicinal plants used by tribals of panchmahals district, gujarat.

An ethnobotanical survey was conduction in 20 tribal villages of Panchamahals district of Gujarat, inhabited by various tribal groups. The present communication records 36 plant species belongings to 34 genera and 27 families used by them in the treatment of various diseases and ailments.

Anti-convulsant therapy in eclampsia.

Seventy four patients presented with eclampsia at N.W.M. Hospital. Bombay. Among the patients with eclampsia, 64.9% were primis, 29.7% were gravida II-IV and 5.4% were grand multis. As many as 40.5% patients were less than 20 years of age, while 2.7% were over 30 years of age. 48.7% had antepartum convulsions, 40.5% had intrapartum convulsions, while 8 patients convulsed in the postpartum period. Besides standard management of eclamptic patients, 3 protocols of anticonvulsant therapy were utilised. 27% were managed with diphenyl hydantoin sodium, 43% with magnesium sulphate, and 30% by combination of diazepam and pentazocine. The maternal and perinatal outcome was evaluated. Control of convulsions was superior with magnesium sulphate while perinatal outcome was best with diphenyl hydantoin.

A random plasma glucose method for screening for gestational diabetes.

Low renal threshold for glucose during pregnancy renders glycosuria less specific for the diagnosis of gestational diabetes. Screening for gestational diabetes was done by utilising random plasma glucose (RPG). RPG was done at the first antenatal visit. In 12,623 patients who registered for antenatal care at the N.W.M. Hospital, 1371 patients had a RPG more than 100 mg%. An oral glucose tolerance test was advised in these patients. The pick-up rate of gestational diabetes correlated with RPG level. Thirty-six cases of gestational diabetes were picked up. The pick up rate is significantly higher as compared to that which would have been detected utilising conventional screening criteria.

Plants of ramayana.

The article presents a list of plants mentioned in Ramayana one of the two great epics of this country which has been compiled and the probable equivalent botanical names have been fixed. This study will be useful to the botanists, palaeo - botanists, ethonobotanists, foresters, naturalists and environmentalists as well.

Ethnomedicine of bhil tribe of jhabua district, m. P.

The Bhils are inhabitants of Dhar, Jhabua, Khargone and Ratlam distrcits of Madhya Pradesh. A large number of Bhils live in the neighbouring States of Maharashtra, Gujarat and Rajasthan. They constitute the third largest tribe of India; the first two being Gonds and Santhals. They utilize a large number of plant species occurring wild in the district as herbal remedies in various diseases and ailments. An ethno-medico-botanical survey was conducted in the tribal blocks. Viz. Kathiware, Alirajpur and Sodhwa blocks of Jhabua district, M. P. The authors have gathered first-hand information on seventy - five plant species and their mode of therapeutic uses from the tribal medicine men 'Badwa' and other experienced tribals. The present study has brought of light some interesting data on potential medicinal plants which will be screened for determining their therapeutic and pharmacodynamic properties.