1.
AAPS PharmSciTech
; 11(1): 221-5, 2010 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20127427
RESUMO
The purpose of this study was to formulate a superporous hydrogel (SPH) containing carvedilol self-nanoemulsifying drug delivery system. Effects of formulation parameters (amount of SPH and 0.1 N HCl used during drug loading) were studied in 3(2) factorial design. Response surface plots showed significant effect of the parameters on hydrogel swelling, carvedilol content, and carvedilol in vitro release. Regression equations were generated to calculate the desirable responses.