Fully Reprogrammable 2D Array of Multi-State Molecular Switching Units.

Integration of molecular switching units into complex electronic circuits is considered to be the next step towards the realization of novel logic and memory devices. Here, we report on an ordered 2D network of neighboring ternary switching units represented by triazatruxene (TAT) molecules organized in a honeycomb lattice on a Ag(111) surface. Using low-temperature scanning tunneling microscopy, we are able to control the bonding configurations of individual TAT molecules within the lattice, realizing up to 12 distinct states per molecule. The switching between those states shows a particularly strong bias dependence ranging from tens of millivolts to volts. Based on a single TAT molecule as a fundamental building block, we then explore the low-bias switching behavior in units consisting of two and more interacting TAT molecules purposefully defined by the high-bias switching within the honeycomb lattice. we demonstrate the possibility to realize up to 9 and 19 distinguishable states in a dyad and a tetrad of coupled switching units, respectively. The switching dynamics can be triggered and accessed by single-point measurements on a single molecule. High experimental control over the desired state, owing to hierarchical switching and pronounced switching directionality, as well as the observed full reversibility, makes this system particularly appealing, paving the way to design complex molecule-based memory systems. This article is protected by copyright. All rights reserved.

[Health care reality of selected pediatric urologic surgeries in Germany from 2006 to 2019]. / Versorgungswirklichkeit ausgewählter kinderurologischer Eingriffe in Deutschland von 2006 bis 2019.

BACKGROUND: The conservative and surgical treatment of children is a fundamental pillar of the urological specialist training program and represents one of the core competencies within urological healthcare. The loss of this expertise has been a reoccurring topic within urologic occupational policy. The aim of this study is to analyse actual case numbers and to compare the distribution and dynamics of pediatric urologic surgeries between the specialist departments of urology and pediatric surgery in Germany. MATERIALS AND METHODS: We defined the surgical treatments of maldecensus testis, hypospadias, and vesicoureteral reflux (VUR) as index interventions. Using the tool reimbursement.INFO (RI Innovation GmbH, Hürth, Germany) we analysed publicly available quality report data of German hospitals between 2006 and 2019. RESULTS: While orchidopexy was more commonly performed in the field of urology, the correction of hypospadias and the surgical treatment of VUR showed higher case numbers in the field of pediatric surgery. Proportionally, there was no relevant shift between urologic and pediatric surgical clinics for orchidopexy and surgical VUR therapy during the study period. For hypospadias corrections, the proportion of surgeries performed in pediatric surgical units is increasing (p < 0.0001). In pediatric surgery 84-93% of the analyzed procedures are performed in high-volume units, while this proportion is 56-73% in urology. In particular, a high proportion of VUR therapy in urology is performed as an occasional procedure (30% very low volume). CONCLUSIONS: The quality report data enable the compilation of case numbers and the analysis of the distribution between urology and pediatric surgery in Germany. Merely the correction of hypospadias has shown a relevant shift towards pediatric surgery. The causes and possible consequences for professional policy of this preliminary investigation are complex and require further analysis.

A preregistered multi-lab replication of Maier et al. (2014, Exp. 4) testing retroactive avoidance.

The term "retroactive avoidance" refers to a special class of effects of future stimulus presentations on past behavioral responses. Specifically, it refers to the anticipatory avoidance of aversive stimuli that were unpredictable through random selection after the response. This phenomenon is supposed to challenge the common view of the arrow of time and the direction of causality. Preliminary evidence of "retroactive avoidance" has been published in mainstream psychological journals and started a heated debate about the robustness and the true existence of this effect. A series of seven experiments published in 2014 in the Journal of Consciousness Studies (Maier et al., 2014) tested the influence of randomly drawn future negative picture presentations on avoidance responses based on key presses preceding them. The final study in that series used a sophisticated quantum-based random stimulus selection procedure and implemented the most severe test of retroactive avoidance within this series. Evidence for the effect, though significant, was meager and anecdotal, Bayes factor (BF10) = 2. The research presented here represents an attempt to exactly replicate the original effect with a high-power (N = 2004) preregistered multi-lab study. The results indicate that the data favored the null effect (i.e., absence of retroactive avoidance) with a BF01 = 4.38. Given the empirical strengths of the study, namely its preregistration, multi-lab approach, high power, and Bayesian analysis used, this failed replication questions the validity and robustness of the original findings. Not reaching a decisive level of Bayesian evidence and not including skeptical researchers may be considered limitations of this study. Exploratory analyses of the change in evidence for the effect across time, performed on a post-hoc basis, revealed several potentially interesting anomalies in the data that might guide future research in this area.

Gamification as an approach to improve resilience and reduce attrition in mobile mental health interventions: A randomized controlled trial.

Forty percent of all general-practitioner appointments are related to mental illness, although less than 35% of individuals have access to therapy and psychological care, indicating a pressing need for accessible and affordable therapy tools. The ubiquity of smartphones offers a delivery platform for such tools. Previous research suggests that gamification-turning intervention content into a game format-could increase engagement with prevention and early-stage mobile interventions. This study aimed to explore the effects of a gamified mobile mental health intervention on improvements in resilience, in comparison with active and inactive control conditions. Differences between conditions on changes in personal growth, anxiety and psychological wellbeing, as well as differences in attrition rates, were also assessed. The eQuoo app was developed and published on all leading mobile platforms. The app educates users about psychological concepts including emotional bids, generalization, and reciprocity through psychoeducation, storytelling, and gamification. In total, 358 participants completed in a 5-week, 3-armed (eQuoo, "treatment as usual" cognitive behavioral therapy journal app, no-intervention waitlist) randomized controlled trial. Relevant scales were administered to all participants on days 1, 17, and 35. Repeated-measures ANOVA revealed statistically significant increases in resilience in the test group compared with both control groups over 5 weeks. The app also significantly increased personal growth, positive relations with others, and anxiety. With 90% adherence, eQuoo retained 21% more participants than the control or waitlist groups. Intervention delivered via eQuoo significantly raised mental well-being and decreased self-reported anxiety while enhancing adherence in comparison with the control conditions. Mobile apps using gamification can be a valuable and effective platform for well-being and mental health interventions and may enhance motivation and reduce attrition. Future research should measure eQuoo's effect on anxiety with a more sensitive tool and examine the impact of eQuoo on a clinical population.

Tip-Induced Inversion of the Chirality of a Molecule's Adsorption Potential Probed by the Switching Directionality.

The switching behavior of surface-supported molecular units excited by current, light, or mechanical forces is determined by the shape of the adsorption potential. The ability to tailor the energy landscape in which a molecule resides at a surface gives the possibility of imposing a desired response, which is of paramount importance for the realization of molecular electronic units. Here, by means of scanning tunneling microscopy, a triazatruxene (TAT) molecule on Ag(111) is studied, which shows a switching behavior characterized by transitions of the molecule between three states, and which is attributed to three energetically degenerate bonding configurations. Upon tunneling current injection, the system can be excited and continuously driven, showing a switching directionality close to 100%. Two surface enantiomers of TAT show opposite switching directions pointing at the chirality of the energy landscape of the adsorption potential as a key ingredient for directional switching. Further, it is shown that by tuning the tunneling parameters, the symmetry of the adsorption potential can be controllably adjusted, leading to a suppression of the directionality or an inversion of the switching direction. The findings represent a molecule-surface model system exhibiting unprecedented control of the shape of its adsorption potential.

The Influence of Decisional and Emotional Forgiveness on Attributions.

Research on forgiveness suggests that forgiveness is an emotion-focused coping process important for clinical settings as it can promote both physical and mental health (Worthington et al., 2005; Witvliet and McCullough, 2007). Investigating antecedents of forgiveness, empirical studies and theoretical models propose that attributions influence forgiveness. However, hardly any studies or theoretical models have ever looked at the possibility that this relationship may be reciprocal in nature and whether forgiveness also impacts a victim's attributions has not been investigated. The present, highly powered (n = 969) study seeks to fill this gap and provides the first empirical support that emotional forgiveness has a strong influence on subsequent attributions. Specifically, individuals, who have emotionally forgiven a transgression, hold the transgressor less responsible for the offense compared to those in the decisional forgiveness and control condition. Moreover, the findings conceptually replicate previous research (Lichtenfeld et al., 2015) by demonstrating that emotional, but not decisional forgiveness affects cognition and, thus, emotional and decisional forgiveness should be treated as distinct facets in the forgiveness process. Implications of these results for clinical and health psychology are discussed.

[Retroperitoneal hemangiopericytoma-a rare case with multiple relapses-even 20 years after primary diagnosis]. / Retroperitoneales Hämangioperizytom ­ ein seltener Fall mit mehrfachen Rezidiven ­ selbst 20 Jahre nach Erstdiagnose.

A 41-year-old man without previous illness presented at our clinic with progressive pain in the lower abdomen and intermittent pain in the left flank. We found a lesion of unknown dignity which had anatomical contact to the bladder and rectum. Histological examination confirmed the diagnosis of hemangiopericytoma. It is grouped under the general term solitary fibrous tumor (SFT). The potential for malignancy varies. To calculate the tendency of metastases or recurrence and overall survival, it is necessary to use a risk stratification model to individualize treatment. Our rare case with an appearance of a relapse 14 and 20 years after the primary resection and progressive proliferation rate underlines the importance of individualized management and long-term and close follow-up of this tumor entity.

Intentional Observer Effects on Quantum Randomness: A Bayesian Analysis Reveals Evidence Against Micro-Psychokinesis.

Intentional effects of human observation on the output of quantum-based random number generators (tRNG) have been studied for decades now. This research has been known as micro-psychokinesis (micro-PK) and many studies in the field reported evidence for mentally induced non-random deviations from chance. A most recent meta-analysis from Bösch et al. (2006) revealed a very small and heterogeneous overall effect size that indicated a significant deviation from chance across studies. There remains doubt among the scientific community on the existence of micro-PK given: (i) the small and heterogenous effect; and (ii) the fact that several independent replication attempts of prominent studies failed to confirm the original results. The study presented here was intended to provide decisive evidence for or against the existence of micro-PK. An online experiment with 12,571 participants was conducted. The Bayesian analysis revealed strong evidence for H0 (BF01 = 10.07). Thus, micro-PK did not exist in the data. A closer inspection of the temporal change of the effect seemed to suggest a non-random oscillative structure with a higher frequency than observed in simulated data. The possible role of entropy and the relation to the model of pragmatic information from von Lucadou (2015) is discussed.

Correction: An International Consensus Definition of the Wish to Hasten Death and Its Related Factors.

[This corrects the article DOI: 10.1371/journal.pone.0146184.].

Redox-Active N-Heterocyclic Germylenes and Stannylenes with a Ferrocene-1,1'-diyl Backbone.

We describe ferrocene-based N-heterocyclic germylenes and stannylenes of the type [Fe{(η5 -C5 H4 )NR}2 E:] (1 RE; E=Ge, Sn; R=neopentyl (Np), mesityl (Mes), trimethylsilyl (TMS)), which constitute the first examples of redox-functionalised N-heterocyclic tetrylenes (NHTs). These compounds are thermally stable and were structurally characterised by means of X-ray diffraction studies, except for the neopentyl-substituted stannylene 1 NpSn, the decomposition of which afforded the aminoiminoferrocene [fc(NHCH2 tBu)(N=CHtBu)] (2) and the spiro tin(IV) compound (1 Np)2 Sn (3). DFT calculations show that the HOMO of the NHTs of our study is localised on the ferrocenylene backbone. A one-electron oxidation process affords ions of the type 1 RE+. . In contrast to the NHC system 1 RC, the localised ferrocenium-type nature of the oxidised form does not compromise the fundamental tetrylene character of 1 RE+. .

Not always a matter of context: direct effects of red on arousal but context-dependent moderations on valence.

The arousal theory of color proposes that red is associated with arousal. Research on the color-in-context theory, in turn, states that the context in which red is perceived influences its valence-related meaning and behavioral responses to it. This study faces and integrates these theories by examining the influence of red on both arousal and valence perceptions of test-relevant and neutral stimuli, rendering a color 2 (red vs. blue) × context 2 (test vs. neutral) between-subjects design. Participants rated different pictures regarding their arousal and valence component, respectively. In line with the assumptions of both theories, red increased arousal perceptions of stimuli irrespective of their valence but a context × color interaction was found for valence perceptions: for participants viewing test-relevant pictures, red increased their perceptions of negativity compared to neutral pictures. The present study shows that both theories are actually compatible when differentiating the arousal and valence component.

An International Consensus Definition of the Wish to Hasten Death and Its Related Factors.

BACKGROUND: The desire for hastened death or wish to hasten death (WTHD) that is experienced by some patients with advanced illness is a complex phenomenon for which no widely accepted definition exists. This lack of a common conceptualization hinders understanding and cooperation between clinicians and researchers. The aim of this study was to develop an internationally agreed definition of the WTHD. METHODS: Following an exhaustive literature review, a modified nominal group process and an international, modified Delphi process were carried out. The nominal group served to produce a preliminary definition that was then subjected to a Delphi process in which 24 experts from 19 institutions from Europe, Canada and the USA participated. Delphi responses and comments were analysed using a pre-established strategy. FINDINGS: All 24 experts completed the three rounds of the Delphi process, and all the proposed statements achieved at least 79% agreement. Key concepts in the final definition include the WTHD as a reaction to suffering, the fact that such a wish is not always expressed spontaneously, and the need to distinguish the WTHD from the acceptance of impending death or from a wish to die naturally, although preferably soon. The proposed definition also makes reference to possible factors related to the WTHD. CONCLUSIONS: This international consensus definition of the WTHD should make it easier for clinicians and researchers to share their knowledge. This would foster an improved understanding of the phenomenon and help in developing strategies for early therapeutic intervention.

A macroscopic violation of no-signaling in time inequalities? How to test temporal entanglement with behavioral observables.

In this paper we applied for the first time the no-signaling in time (NSIT) formalism discussed by Kofler and Brukner (2013) to investigate temporal entanglement between binary human behavioral unconscious choices at t1 with binary random outcomes at t2. NSIT consists of a set of inequalities and represents mathematical conditions for macro-realism which require only two measurements in time. The analyses of three independent experiments show a strong violation of NSIT in two out of three of them, suggesting the hypothesis of a quantum-like temporal entanglement between human choices at t1 with binary random outcomes at t2. We discuss the potentialities of using NSIT to test temporal entanglement with behavioral measures.

Forgive and Forget: Differences between Decisional and Emotional Forgiveness.

To forgive and forget is a well-known idiom, which has rarely been looked at empirically. In the current experiment, we investigated differences between emotional and decisional forgiveness on forgetting. The present study provides the first empirical support that emotional forgiveness has a strong influence on subsequent incidental forgetting. Specifically, our results demonstrate that emotional forgiveness leads to substantially higher levels of forgetting in respect to offense relevant traits compared to both decisional forgiveness and no forgiveness. This provides evidence for our hypothesized effect that only individuals who have emotionally forgiven a transgression, and not those who just decided to forgive, subsequently forget offense relevant traits attributed to the transgressor.

Red - take a closer look.

Color research has shown that red is associated with avoidance of threat (e.g., failure) or approach of reward (e.g., mating) depending on the context in which it is perceived. In the present study we explored one central cognitive process that might be involved in the context dependency of red associations. According to our theory, red is supposed to highlight the relevance (importance) of a goal-related stimulus and correspondingly intensifies the perceivers' attentional reaction to it. Angry and happy human compared to non-human facial expressions were used as goal-relevant stimuli. The data indicate that the color red leads to enhanced attentional engagement to angry and happy human facial expressions (compared to neutral ones) - the use of non-human facial expressions does not bias attention. The results are discussed with regard to the idea that red induced attentional biases might explain the red-context effects on motivation.

Physical and psychological factors and the wish to hasten death in advanced cancer patients.

BACKGROUND: Qualitative research suggests that the wish to hasten death (WTHD) in the advanced stages of disease is mainly related to overall suffering. This quantitative study explores the relationship between the WTHD and psychological and physical factors, including survival, in patients with advanced cancer. METHODS: Cross-sectional study of 101 advanced cancer patients admitted to an acute Palliative Care Unit (PCU) and followed-up for survival. Patients were assessed using the Schedule of Attitudes toward Hastened Death (SAHD). The Hospital Anxiety and Depression Scale (HADS), Eastern Cooperative Oncology Group Performance Status, and the Barthel Index were used to assess psychological and physical status. Survival prognosis was based on the Palliative Prognostic score. RESULTS: The Spanish adaptation of SAHD showed good psychometric properties (Cronbach's alpha 0.92; similar concurrent/discriminant validity to the original). The mean total score on SAHD was 4.9 (standard deviation [SD] = 5.3). SAHD scores were positively correlated with HADS-Total (r = 0.332, p < 0.01), HADS-Depression (r = 0.397, p < 0.01), Eastern Cooperative Oncology Group Performance Status (r = 0.276, p < 0.01), and Palliative Prognostic score (r = 0.248, p < 0.05) and negatively correlated with the Barthel Index (r = -0.324, p < 0.01). Women scored higher than men on SAHD (6.2, SD = 5.9 vs. 4.2, SD = 4.8, p < 0.01). No association was found between WTHD and survival (r = -0.12, p > 0.05). CONCLUSIONS: Both psychological and physical impairment (as well as poorer prognosis) are associated with higher scores on SAHD, supporting the idea that WTHD emerges in response to overall suffering. Although we observed a direct relationship between physical status and survival, the latter was not related to any of the psychological factors or WTHD.

Color psychology: effects of perceiving color on psychological functioning in humans.

Color is a ubiquitous perceptual stimulus that is often considered in terms of aesthetics. Here we review theoretical and empirical work that looks beyond color aesthetics to the link between color and psychological functioning in humans. We begin by setting a historical context for research in this area, particularly highlighting methodological issues that hampered earlier empirical work. We proceed to overview theoretical and methodological advances during the past decade and conduct a review of emerging empirical findings. Our empirical review focuses especially on color in achievement and affiliation/attraction contexts, but it also covers work on consumer behavior as well as food and beverage evaluation and consumption. The review clearly shows that color can carry important meaning and can have an important impact on people's affect, cognition, and behavior. The literature remains at a nascent stage of development, however, and we note that considerable work on boundary conditions, moderators, and real-world generalizability is needed before strong conceptual statements and recommendations for application are warranted. We provide suggestions for future research and conclude by emphasizing the broad promise of research in this area.

Morals matter in economic games.

Contrary to predictions from Expected Utility Theory and Game Theory, when making economic decisions in interpersonal situations, people take the interest of others into account and express various forms of solidarity, even in one-shot interactions with anonymous strangers. Research in other-regarding behavior is dominated by behavioral economical and evolutionary biological approaches. Psychological theory building, which addresses mental processes underlying other-regarding behavior, is rare. Based on Relational Models Theory (RMT, [1]) and Relationship Regulation Theory (RRT, [2]) it is proposed that moral motives influence individuals' decision behavior in interpersonal situations via conscious and unconscious (automatic) processes. To test our propositions we developed the 'Dyadic Solidarity Game' and its solitary equivalent, the 'Self-Insurance Game'. Four experiments, in which the moral motives "Unity" and "Proportionality" were manipulated, support the propositions made. First, it was shown that consciously activated moral motives (via framing of the overall goal of the experiment) and unconsciously activated moral motives (via subliminal priming) influence other-regarding behavior. Second, this influence was only found in interpersonal, not in solitary situations. Third, by combining the analyses of the two experimental games the extent to which participants apply the Golden Rule ("treat others how you wish to be treated") could be established. Individuals with a "Unity" motive treated others like themselves, whereas individuals with a "Proportionality" motive gave others less then they gave themselves. The four experiments not only support the assumption that morals matter in economic games, they also deliver new insights in how morals matter in economic decision making.

The red-attractiveness effect, applying the Ioannidis and Trikalinos (2007b) test, and the broader scientific context: a reply to Francis (2013).

Francis (2013) tested for and found evidence of publication bias in 1 of the 3 focal relations examined in Elliot et al. (2010), that between red and attractiveness. He then called into question the research as a whole and the field of experimental psychology more generally. Our reply has 3 foci. First, we attend to the bottom line regarding the red-attractiveness effect; it has already been replicated and extended by several independent laboratories. Second, we note that the test applied to our research is an exploratory test meant to be used cautiously and highlight ways in which the application to our research seems incautious. Third, we place the critique in the broader context of the prevailing norms and practices of the field and suggest that the preferred approach to reevaluating and revising the system currently in place is the frank, creative exchange of ideas already underway.

Color in context: psychological context moderates the influence of red on approach- and avoidance-motivated behavior.

BACKGROUND: A basic premise of the recently proffered color-in-context model is that the influence of color on psychological functioning varies as a function of the psychological context in which color is perceived. Some research has examined the appetitive and aversive implications of viewing the color red in romance- and achievement-relevant contexts, respectively, but in all existing empirical work approach and avoidance behavior has been studied in separate tasks and separate experiments. Research is needed to directly test whether red influences the same behavior differently depending entirely on psychological context. METHODOLOGY/PRINCIPAL FINDINGS: The present experiment was designed to put this premise to direct test in romance- and achievement-relevant contexts within the same experimental paradigm involving walking behavior. Our results revealed that exposure to red (but not blue) indeed has differential implications for walking behavior as a function of the context in which the color is perceived. Red increased the speed with which participants walked to an ostensible interview about dating (a romance-relevant context), but decreased the speed with which they walked to an ostensible interview about intelligence (an achievement-relevant context). CONCLUSIONS/SIGNIFICANCE: These results are the first direct evidence that the influence of red on psychological functioning in humans varies by psychological context. Our findings contribute to both the literature on color psychology and the broader, emerging literature on the influence of context on basic psychological processes.