Role of moxifloxacin-dexamethasone in cardiac histomorphometric findings among Wistar rats from infected mothers.

PURPOSE: To investigate cardiac changes in young rats, whose mothers underwent autogenic fecal peritonitis, during organogenesis phase and to evaluate the role of intravenous administration of moxifloxacin and dexamethasone in preventing infection-related cardiac changes. METHODS: A prospective histomorphometric study was performed on 29 hearts of Wistar four-month old rats. Animals were divided into three groups: Negative Control Group (NCG) included 9 subjects from healthy mothers; Positive Control Group (PCG) included 10 subjects from mothers with fecal peritonitis (intra-abdominal injection of 10% autogenic fecal suspension in the gestational period) and did not receive any treatment; and Intervention Group (IG), with 10 animals whose infected mothers received moxifloxacin and dexamethasone treatment 24 hours after induction of fecal peritonitis. RESULTS: Nuclear count was higher in the IG group as compared to PCG (p = 0.0016) and in NCG as compared to PCG (p = 0.0380). There was no significant difference in nuclear counts between NCG and IG. CONCLUSION: Induced autogenic fecal peritonitis in pregnant Wistar rats determined myocardial changes in young rats that could be avoided by the early administration of intravenous moxifloxacin and dexamethasone.

Role of moxifloxacin-dexamethasone in cardiac histomorphometric findings among Wistar rats from infected mothers

Abstract Purpose: To investigate cardiac changes in young rats, whose mothers underwent autogenic fecal peritonitis, during organogenesis phase and to evaluate the role of intravenous administration of moxifloxacin and dexamethasone in preventing infection-related cardiac changes. Methods: A prospective histomorphometric study was performed on 29 hearts of Wistar four-month old rats. Animals were divided into three groups: Negative Control Group (NCG) included 9 subjects from healthy mothers; Positive Control Group (PCG) included 10 subjects from mothers with fecal peritonitis (intra-abdominal injection of 10% autogenic fecal suspension in the gestational period) and did not receive any treatment; and Intervention Group (IG), with 10 animals whose infected mothers received moxifloxacin and dexamethasone treatment 24 hours after induction of fecal peritonitis. Results: Nuclear count was higher in the IG group as compared to PCG (p = 0.0016) and in NCG as compared to PCG (p = 0.0380). There was no significant difference in nuclear counts between NCG and IG. Conclusion: Induced autogenic fecal peritonitis in pregnant Wistar rats determined myocardial changes in young rats that could be avoided by the early administration of intravenous moxifloxacin and dexamethasone.

Percutaneous mitral valvuloplastry in a pregnant woman guided only by the transesophageal echocardiography.

Mitral valve stenosis is the most common valve lesion in pregnancy. In spite of an optimized clinical treatment and a favorable valve anatomy according to Wilkins and Block score, in symptomatic patients, percutaneous intervention is shown to be of great importance. In these patients, avoiding x-ray exposure as much as possible is recommended so as to protect the fetus from the deleterious effects of ionizing radiation. In this case report, a 24-year old pregnant patient with severe mitral stenosis (valve area of 0.9 cm(2)) was successfully submitted to a TEE-guided percutaneous treatment, without the use of x-ray.

Cardiomiopatia de Takotsubo como causa de infarto agudo do miocárdio em paciente em uso de anti-histamínico associado a pseudo-efedrina / Acute myocardial infarction resulting from takotsubo cardiomyopathy in patient on antihistaminics

Relatamos o caso de uma senhora de 77 anos, que vinha em uso de anti-histamínico associado a pseudo-efedrina por processo alérgico de vias aéreas superiores, admitida no Pronto Socorro com quadro de infarto agudo do miocárdio com elevação do segmento ST em parede ântero-lateral. O cateterismo cardíaco revelou artérias coronárias tortuosas e sem lesões obstrutivas, com hipercontratilidade esquerda. Devido a derrames pericárdicos de repetição, foi submetida à drenagem pleuro-pericárdica. Causas reumatológicas foram excluídas. Após 30 dias, recebeu alta em boas condições clínicas...

This is the report on a 77-year-old female patient on antihistaminic associated to pseudoephedrin to treat an allergy conditionin upper airways. The patient was admitted to the Emergency Unit with acute myocardial infarction and ST segment elevation in the antero-lateral wall. Cardiac catheterism showed tortuous coronaries, no obstructive lesions, and baselinehypercontractility associated to antero-apical akinesia on left ventriculography. As a result of repeated pericardial strokes, the patient was submitted to pleuro-pericardial drainage. Rheumatological causes were ruled out. The patient was discharged after 30 days in good clinical conditions.

Valvoplastia mitral percutânea em paciente gestante guiada apenas pelo ecocardiograma transesofágico / Percutaneous mitral valvuloplastry in a pregnant woman guided only by the transesophageal echocardiography

A estenose da válvula mitral é a lesão de válvula mais comum durante a gravidez. Apesar de um tratamento clínico eficaz e de uma anatomia valvular favorável, de acordo com o critério de Wilkins e Block [score de Wilkins-Block], a intervenção percutânea em pacientes sintomáticas mostra-se muito importante. Nessas pacientes, recomenda-se evitar ao máximo a exposição aos raios X para proteger o feto dos efeitos deletérios da radiação ionizante. Neste relato de caso, uma paciente de 24 anos, grávida, com grave estenose mitral (área valvular de 0,9 cm²), foi submetida com sucesso a um tratamento percutâneo com ETE-guiado, sem o uso de raios X.

Mitral valve stenosis is the most common valve lesion in pregnancy. In spite of an optimized clinical treatment and a favorable valve anatomy according to Wilkins and Block score, in symptomatic patients, percutaneous intervention is shown to be of great importance. In these patients, avoiding x-ray exposure as much as possible is recommended so as to protect the fetus from the deleterious effects of ionizing radiation. In this case report, a 24-year old pregnant patient with severe mitral stenosis (valve area of 0.9 cm²) was successfully submitted to a TEE-guided percutaneous treatment, without the use of x-ray.

Freqüência dp anti-VHC em doadores de sangue de Campina Grande, Paraíba / Frequency of anti_HCV in blood donors from Campina Grande - Paraíba

Entre candidatos à doação de sangue de grandes centros urbanos da região nordeste do Brasil, a frequência de portadores de anticorpos contra o virus da hepatite C (anti-VHC) foi estimada em 1,2por cento. Mas são escassos ou inexistentes os estudos em amostras de cidades de pequeno ou médio porte do nordeste brasileiro, como a de Campina Grande, Paraíba. foram aaliados 28.957 candidatos à doação de sangue de quatro bancos de sangue ou serviços de hemoterapia de Campina Grande e, entre esses, 196 (0,68por cento) foram anti-VHC (ELISA-III) positivo, sendo a média de idade de 39,3 (ñ10,2) anos e 95,0por cento (n=186) do gênero masculino. a freqüência do portadores de anti-VHC nos serviços privados (0,5por cento) foi significativamente menor (p<0,0000002) que a observada nos públicos (1,1por cento). Em conclusão, a menor freqüência de portadores anti-VHC em Campina Grande, provavelmente, decorre das características epidemiológicas mais peculiares às cidades de menor porte e ainda com forte influência do meio rural. Por sua vez, a menor freqüência nos serviços privados pode ser conseqüência das caracteristicas do candidato à doação de sangue e/ou do processo de seleção