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1.
Sci Rep ; 14(1): 13594, 2024 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-38867065

RESUMO

This research presents a compact portable electronic gas sensor that can be monitored through a smartphone application. The smart sensor utilizes three state-of-the-art sensors. The sensors integrate an ESP8266 microcontroller within the same device. This facilitates their integration with the electronics and enhances their performance. Herein, primarily focuses on utilizing the sensor to detect carbon monoxide. This article outlines the fabrication process of a gas sensor utilizing a P-N heterojunction, eliminating the need for a binder. The sensor consists of CuO/copper foam nanowires and hierarchical In2O3. In order to verify the system's functionality, it underwent testing with various levels of CO concentrations (10-900 ppm), including particular tests designed to examine the device's performance in different humidity and temperature circumstances. A mobile application for the provision of monitoring services has been developed at last. To process the information obtained from the gas sensor, an algorithm has been constructed, trained, and integrated into a smartphone for this purpose. This research demonstrated that a smartphone-coupled gas sensor is a viable system for real-time monitoring and the detection of CO gas.

2.
Sci Rep ; 13(1): 6217, 2023 04 17.
Artigo em Inglês | MEDLINE | ID: mdl-37069217

RESUMO

This paper reports on developing a low cost but efficient paired emitter-detector diode (PEDD)-based photometer. The photometer consists of a white light-emitting diode (LED) as the emitter diode, an RGB LED as the detector diode, and a multimeter for recoding the signal. The developed PEDD-based photometer was utilized for the determination of liquid bleach adulteration in cow milk samples. N,N-Diethyl-p-phenylenediamine sulfate aqueous solution of pH 6 was used as a probe to monitor the presence of residual active chlorine in milk. The results showed that the developed method could be used to determine sodium hypochlorite in the concentration range of 0.5 to 20.0 ppm Cl2 with 0.14 and 0.46 ppm Cl2 limit of detection and limit of quantification, respectively. The intraday and interday precisions of the method at two concentration levels of 5.5 and 13.7 ppm Cl2 were 1.04% and 0.52%, and 1.81% and 1.02%, respectively. The recoveries of 114.2% and 106.9% were obtained for 5.5 and 13.7 ppm Cl2 concentrations levels, respectively. Real sample analyzes results showed that "maybe" liquid bleach adulteration in milk is the case for local distributors of raw milk.


Assuntos
Leite , Hipoclorito de Sódio , Animais , Fotometria/métodos
3.
Neurochem Res ; 37(4): 778-85, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22201038

RESUMO

Most of the modulating effects of cannabinoids on pain are through putative cannabinoid CB1 and CB2 receptors. However, the involvement of other receptors is also suggested. Cannabinoid compounds with analgesic activity such as palmitoylethanolamide (PEA) show low affinity to CB1 and CB2 receptors, yet selectively activate GPR55 receptors. The objective of the present study was to evaluate the possible role of spinal CB1 and GPR55 receptors on antinociceptive activity of PEA in formalin test as well as in the spinal expression of IL1-ß in rat. Intrathecal (i.t.) administration of PEA (1, 10 µg) significantly decreased both pain-related scores in formalin test and IL1-ß expression in rat spinal cord. Pretreatment of rats with low doses of CB1 receptor antagonist/GPR55 receptor agonist AM251 (10, 100 ng; i.t.), did not attenuated the effect of PEA, yet even significantly increased the effect of PEA on IL1-ß expression in rat spinal cord. Interestingly, i.t. administration of low doses of AM251 per se significantly decreased both pain related behavior and spinal IL1-ß expression in formalin test. These findings suggest the possible involvement of receptors other than CB1 receptors in spinal pain pathways, such as GPR55, in pain modulating activity of cannabinoids.


Assuntos
Endocanabinoides/administração & dosagem , Etanolaminas/administração & dosagem , Interleucina-1beta/biossíntese , Medição da Dor , Dor/metabolismo , Ácidos Palmíticos/administração & dosagem , Piperidinas/administração & dosagem , Pirazóis/administração & dosagem , Medula Espinal/metabolismo , Amidas , Animais , Interações Medicamentosas/fisiologia , Endocanabinoides/metabolismo , Etanolaminas/metabolismo , Injeções Espinhais , Masculino , Dor/tratamento farmacológico , Medição da Dor/efeitos dos fármacos , Ácidos Palmíticos/metabolismo , Piperidinas/metabolismo , Pirazóis/metabolismo , Ratos , Ratos Wistar , Receptor CB1 de Canabinoide/antagonistas & inibidores , Receptor CB1 de Canabinoide/metabolismo , Receptores de Canabinoides/metabolismo , Receptores Acoplados a Proteínas G/agonistas , Receptores Acoplados a Proteínas G/metabolismo , Medula Espinal/efeitos dos fármacos
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