RESUMO
Stable suspensions of NiO and/or Mn304 nanoparticles with average diameter 16,7?8,2 nm and 18,4?5,4 nm respectively, obtained via laser ablation of the metals with 99,99% purification in deionized water, were injected intraperitoneally into rats in dose of 0,5 mg or 0,25 mg three times per week up to 18 times separately or in various dose combinations. A group of rats received combined injections of nanoparticles in the highest dose or merely water with oral <
Assuntos
Nanopartículas/toxicidade , Níquel/toxicidade , Óxidos/toxicidade , Substâncias Protetoras/farmacologia , Animais , Encéfalo/efeitos dos fármacos , Encéfalo/patologia , Sinergismo Farmacológico , Feminino , Rim/efeitos dos fármacos , Rim/patologia , Fígado/efeitos dos fármacos , Fígado/patologia , Compostos de Manganês/farmacocinética , Níquel/farmacocinética , Óxidos/farmacocinética , Ratos , Baço/efeitos dos fármacos , Baço/patologia , Distribuição Tecidual , Testes de Toxicidade SubcrônicaRESUMO
Extremely high toxicity of metal-containing nanoparticles necessitates search of methods to increase body resistance against its harmful effects. The authors' experiments summarized in the article demonstrated that some combinations of certain biologically active substances selected according to sound theoretic background and prescribed in harmless doses can significantly decrease integral and specific manifestations of organ and system toxicity and even genotoxicity of such nanoparticles. Further development of this research direction should be recommended for practical implementation.